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Articles by Gulten Okmen
Total Records ( 2 ) for Gulten Okmen
  Gulten Okmen , Aysel Ugur , Nurdan Sarac and Tulin Arslan
  In this study, usability of plant essential oils from Lamiaceae species for Aeromonas salmonicida infections was investigated under in vitro and in vivo conditions. A total of 18 A. salmonicida strains were obtained from the organs and tissues of locally cultured rainbow trout. All strains were 100% resistant to penicillin, trimethoprim and bacitrasin. All strains showed widest resistance profile to antibiotics. Antibacterial effects of essential oils obtained through water distillation of aerial parts of 4 Lamiaceae species (Origanum onites, Origanum vulgare sp. hirtum, Thymbra spicata var. intricata and Satureja thymbra) were high on 17 out of 18 strains and inhibition zones ranged between 14-25, 12-26, 10-30 and 10-33 mm, respectively but none of them was effective on A. salmonicida FC84 strain. The most sensitive bacteria to Origanum essential oils was A. salmonicida FC29 strain and the most effective essential oil was S. thymbra’s. Therefore, MIC value of this essential oil on FC29 strain was determined. Then, the MIC value (800 μg) of this essential oil were injected to experimental fishes for in vivo studies. Injection of the most effective dose of S. thymbra essential oil and its several dilutions (400, 200, 100 μg μL-1) caused toxic effect and total mortality of experimental fishes. The essential oil at the doses with low or no toxic effect did not increase the bactericidal activity of fish blood indicating that it does not protect rainbow trout against A. salmonicida infections. On the other hand, S. thymbra essential oil at non-toxic low dosages can be used as immune stimulant.
  Gulten Okmen and Onur Turkcan
  In this study, E. angustifolia L. was collected from different localities of Mugla in Turkey. Antibacterial and antioxidant activities of E. angustifolia L. have not been reported to the present day. The aim of the present study was to investigate the in vitro antibacterial and antioxidant activity of methanol extracts of E. angustifolia leaves. Methanol extracts were screened for antibacterial activity against mastitis pathogens. These bacteria include 2 Staphylococcus aureus and 5 Coagulase Negative Staphylococci. Antibacterial activities of the extracts were determined by the Disc Diffusion Method. Also ampicillin disc was used for comparison of inhibition zones. Methanolic leaf extract showed a maximum zone of inhibition in Staphylococcus aureus-17 by Disc Diffusion Method. E. angustifolia leaf extract showed lowest antibacterial activity against S. aureus-18 and Coagulase Negative Staphylococci-36 (CNS). The antioxidant activity of the leaf extract was also determined by ABTS Method using trolox as standard. The value found in ABTS Method is highly effective (84%). As a result, the in vitro studies clearly indicate that the methanolic leaf extract of E. angustifolia significant antioxidant activity and also a better source of natural antioxidant which might be helpful in preventing the process of different oxidative stress. In addition to, the E. angustifolia could be used in treating disease caused by the test bacteria. E. angustifolia methanolic leaf extracts have antioxidant and antibacterial potential.
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