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Articles by Goudarz Sadeghi-Hashjin
Total Records ( 3 ) for Goudarz Sadeghi-Hashjin
  Goudarz Sadeghi-Hashjin and Hovig Manokzadeh
  This study was designed to challenge this important issue in healthy animals. The effects of atropine, cyclopentolate and tropicamide was studied on IOP in the rabbit. For this, 12 healthy and adult white New Zealand rabbits were used. Drugs were applied topically once daily for 14 days. IOP was measured using Schiötz tonometer 5 min after surface anesthesia before the instillation of the next dose of the antimuscarinics. Three drops of a 1% concentration was applied on one eye and the other eye served as control and received saline solution only. IOP was increased during the treatment period with a peak value up to 39, 29 and 39% with atropine, cyclopentolate and tropicamide, respectively (p<0.001). The IOP was still high one day after cessation of the treatment and returned to the baseline levels 7 days after termination of the treatment. In conclusion, chronic administration of antimuscarinics may lead to a critically increased IOP of normotensive eyes. These agents should be considered serious risks not only for patients with glaucoma, but also for subjects with no ophthalmologic problems.
  Vahid Najati , Minoo Ilkhanipour , Shahpar Salehi and Goudarz Sadeghi-Hashjin
  The aim of this study was to investigate the role of Nitric Oxide (NO) in the atresia of ovarian follicles in an animal model. Twenty adult, female rats (90 days old with body weights of 210 ± 10 g in the beginning of the experiments) were divided into 4 groups of 5 each. They were treated twice daily from the subcutaneous route for 21 successive days with either of the following chemicals: nitroglycerine, L-arginine, L-NAME, or saline. On day 22, all animals were sacrificed. Ovaries were dissected out free of connected tissue and were fixed in formaline 10%. Later, paraffine blocks were prepared and serial sections were made by means of H and E routine staining method. Intact and atretic follicles were counted separately. In addition, damages were analyzed qualitatively from the points of view of appearance and morphologic changes. In the evaluation of ovarian follicular structures, different types of healthy as well as atretic follicles were observed. In most of atretic follicles, the oocytes were abnormally elongated and increnation of their outlines were obvious. There were numerous macrophages around and inside of the atretic follicles. Our investigation regarding the distribution of atretic follicles in the ovaries of test groups revealed that atretic follicles in the L-NAME treated group were increased in comparison to the control group. Conversely, however, in the arginine-treated group, the atretic follicles were reduced compared to the control animals. Treatment with nitroglycerine of the rats decreased the number of atretic follicles significantly (p<0.05) in comparison to the control group. In conclusion, enhanced NO, either from endogenous or exogenous origins, prevents atresia phenomenon, while inhibition of NO exerts an opposite effect.
  Goudarz Sadeghi-Hashjin , Mahdieh Moslemi and Shahram Javadi
  The aim of the present study was to study the effect of two selected agents of this group on blood glucose levels in an animal model. Forty-two adult male mice were divided into 7 groups of 6 each. Animals were exposed by their entire tail for 10 sec once a day for 7 successive days to either 0, 0.1, 1, or 10% azynphos methyl (AZP) malathion (MLT). On days 1, 4 and 8, a small drop of blood was taken from tail of the animals that had been kept fasted overnight. Blood glucose levels were measure using a glucometer. The animals then were fed and after 1 h the blood glucose measurement was performed again. Results of this study indicated that the administration of organophosphate agents significantly prevented from the rise of blood glucose after feeding in comparison to the control animals. This reached the level of statistical significance on day 1 with MLT 1% (p<0.001). It is concluded that exposure with organophosphate pesticides may suppress excessive blood glucose levels with no effect on the basal blood glucose in the fasting animals.
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