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| Articles
by
Gopikunte Jayaramaiah Ranganath |
Total Records (
2 ) for
Gopikunte Jayaramaiah Ranganath |
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Mani Saminathan
,
Ram Bahal Rai
,
Kuldeep Dhama
,
Ruchi Tiwari
,
Sandip Chakraborty
,
Amarpal
,
Gopikunte Jayaramaiah Ranganath
and
Kandasamy Kannan
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The miracle medicinal plant Morinda citrifolia L., also called as Noni, Great Morinda or Indian mulberry, belongs to the family Rubiaceae. Its fruit has been used traditionally for more than 2000 years by native Polynesians. However, all parts of the plant have medicinal properties. More than 160 phytochemicals have been isolated from the plant Noni which makes it an amazing herbal remedy for the treatment of numerous disorders including cancer. Recently, the Noni juice has been in high demand in market as Complementary and Alternative Medicine (CAM) for its multi-dimensional health benefits. It is a potent antibacterial, antiviral, antifungal, antihelminthic, anticancer, analgesic, anti-inflammatory, anti-oxidant, hypotensive, cardiovascular protective, wound healer, anxiolytic, sedative, antigout, antiobesity and immune enhancing agent. Anticancerous activity of Morinda citrifolia is attributable to its anti-inflammatory, antioxidant and apoptosis-inducing effects. Based on toxicological and mutagenicity assessment, Noni juice has been considered as safe. Few reports of hepatotoxicity exist, although there are many evidences suggesting hepatoprotective effects of Noni. Even though large number of in vitro studies has been carried out but only few clinical trials exist in the literature to suggest real beneficial effects of Noni in humans. Recently, Noni fruit juice has been accepted as a novel food element in the European Union. A number of scientific studies have been conducted to elucidate the mechanism of action of phytoconstituents of Noni. In this review, active phytochemical constituents, pharmacological properties, mechanism of action and various immunomodulatory and therapeutic potentials of Noni usage as a useful herbal medicine are discussed in detail which could be very helpful in safeguarding health of humans and their companion animals. A special focus has been made on the potent utility of this wonderful herbal plant in preventing and treating the deadly malady of cancer. |
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Mani Saminathan
,
Ram Bahal Rai
,
Kuldeep Dhama
,
Babu Lal Jangir
,
Subramaniyam Suresh
,
Gopikunte Jayaramaiah Ranganath
,
Inbaraj Sophia
,
Kuppusamy Karuppanasamy
,
Singaram Barathiraja
and
Arumugam Gopalakrishnan
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N-Methyl-N-Nitrosourea (NMU) is a highly specific mammary gland carcinogen
that act directly and does not require metabolic activation. The novel medicinal
plant Morinda citrifolia, also called as Noni, has broad therapeutic
effects such as antibacterial, antiviral, antifungal, anticancer, analgesic,
anti-inflammatory, anti-oxidant and immune enhancing effects. The present study
was conducted to assess the beneficial effects of M. citrifolia fruit
juice on antioxidant, hematological and biochemical alterations caused by NMU
induced mammary carcinogenesis in Sprague-Dawley rats. The rats were divided
into five groups viz., vehicle control group-A (n = 8), M. citrifolia
control group-B (n = 8), NMU control group C (n = 15), M. citrifolia prevention
group-D (n = 15) and M. citrifolia treatment group-E (n = 15). By the
end of the 28 weeks experimental period all the animals were euthanized, blood
was collected by heart puncture. M. citrifolia treatment significantly
(p<0.05) increased the anti-oxidant enzymes such as catalase, superoxide
dismutase and significantly (p<0.05) decreased the lipid peroxidation activity
when compared to NMU control group-C. M. citrifolia exhibited a preventive
effect against anaemia, lymphocytosis and neutrophilia in group-D and group-E
when compared to group-C. Biochemical analyses showed normal levels of enzymes
of liver and kidney in M. citrifolia treated groups- B, D and E rats,
whereas NMU control group-C showed significant (p<0.05) decrease in albumin
and total protein levels. These findings indicate that M. citrifolia fruit
juice did not show any hepatotoxic or nephrotoxic effects. It was concluded
that the M. citrifolia fruit juice ameliorates the adverse effects of
NMU carcinogenesis and could be useful to treat mammary tumours in humans and
animals. |
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