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Articles by Gopal Krishna Rao
Total Records ( 3 ) for Gopal Krishna Rao
  M.A. Pasha , V.P. Jayashankara , K.N. Venugopala and Gopal Krishna Rao
  A straightforward and a general method has been developed for the synthesis of some important functionalized 4-arylmethylidene-2-phenyl-5(4H)-oxazolone derivatives by combining araldehydes and hippuric acid in the presence of catalytic amount of zinc oxide at room temperature in ethyl alcohol is reported. The method was very easy, rapid and products obtained were in excellent yields. The compounds were purified, characterized and were subjected for in vitro antibacterial activity (determination of Minimum Inhibitory Concentration (MIC) by micro titration method) using two standard drugs Streptomycin and Ampicillin against Bacillus subtilis and Escherichia coli. Five of the synthesized compounds showed remarkable antibacterial activity when compared to that of standards.
  Gopal Krishna Rao , K.N. Venugopala and P.N. Sanjay Pai
  The present investigation was aimed to study the effect of bioisosteric replacement of sulfur with oxygen with regard to antibacterial activity. Hence some new bioisosteric analogues of benzothiophen derivatives namely schiff bases of 4-hydroxy 6-carboxhydrazino benzofuran for antibacterial activity were carried out. The title compounds were characterized on the basis of spectroscopic techniques viz. IR, 1H-NMR, Mass spectral studies and evaluated for their qualitative and quantitative antibacterial activity by agar cup plate method and micro titration method, respectively. From the biological activity it was possible to observe that some of the substituents such as chloro, dimethylamino, hydroxy and methyl on the phenyl ring of the benzofuran analogs influenced the biological activity.
  K.N. Venugopala , Gopal Krishna Rao and P.N. Sanjay Pai
  A versatile method for the synthesis of novel schiff bases of 4-hydroxy 6-carboxhydrazino benzothiophene derivative was described. The title compounds were characterized on the basis of spectroscopic techniques and evaluated for their qualitative and quantitative antibacterial activity by agar cup plate method and micro titration method, respectively. From the biological activity it was possible to observe that some of the substituents on the phenyl ring of the benzothiophene analogs influenced the biological activity.
 
 
 
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