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Articles by Golam Sadik
Total Records ( 10 ) for Golam Sadik
  Atiqur Rahaman , Abu Sayeed , Anwarul Islam , Dulaly Chowdhury , Golam Sadik and G. R. M. Astaq Mohal Khan
  A triterpenoid, Bet-20(29)-en-3-ol-28-oic acid (1) was isolated from the ethyl acetate extract of Nymphoides cristatum (Roxb.) O.kuntze and its structure was elucidated on the basis of spectral evidences. This is the first report of isolation of this compound from this plant. The compound was screened for antimicrobial activity against a number of pathogenic bacteria and fungi and the cytotoxic activity by brine shrimp lethality bioassay. The test agent exhibited significant antimicrobial activity against most of the bacteria and fungi. The minimum inhibitory concentration (MIC) of the test agent determined against Bacillus cereus, Bacillus subtilis, Escherichia coli and Shigella sonnei was found to be 64, 128, 64 and 32 μg/ml respectively. The compound also showed prominent cytotoxic activity. The LC50 (median lethal concentration) was 15.39 μg/ml. 50.
  Golam Sadik , M. A. Gafur , M. Shah Alam Bhuiyan , A. H. M. Khurshid Alam , M. Helal U. Biswas , Parvez Hassan , Abdul Mannan , M. Omar Faruk Khan and A. K. A. Chowdhury
  The ethanolic extract of Pergularia daemia and its steroidal fraction were studied for antifertility activity. Both the ethanol extract and the steroidal fraction showed significant antifertility activity in the pre-implantation stage in female mice. The ethanol extract also showed late abortifacient activity
  Farque Ahmed , Abu Sayeed , Anwarul Islam , S. M. Abdus Salam , Golam Sadik and G. R. M. Astaq Mohal Khan
  The ethyl acetate (C2H5COOCH3) extract of the roots of Vanda roxburghii Br. is known to have a significant antimicrobial activity. The investigation was carried out on the C2H5COOCH3 extract for the isolation and characterization of the active principle (s). The extract afforded a glycoside, 17-β-hydroxy-14, 20-epoxy-1-oxo- [22R]-3β-[O-β-D-glucopyranosyl]-5,24-withadienolide (VR-2), the structure of which was elucidated on the basis of spectral evidences. Compound VR-2 was screened against a wide variety of pathogenic bacteria and fungus for its antimicrobial activity by disc diffusion method. The compound showed significant antibacterial activity against most of the tested strain of bacteria and produced zone of inhibition between 14 to 28mm. The compound also showed significant antifungal activity and the minimum inhibitory concentration (MIC) of VR-2 against Bacillus cereus, Bacillus subtilis, Escherichia coli, Shigella dysenteriae and pseudomonus aeruginosa was determined and the values were 8, 32, 16, 8 and 16μg ml-1, respectively.
  Anwarul Islam , Abu Sayeed , Golam Sadik , M. Motiur Rahman and G. R. M. Astaq Mohal Khan
  Two clerodane diterpines viz., Kolavenic acid (1) and 16-oxo-cleroda-3, 13(14) E-diene-15-oic acid (2) were isolated from the petroleum ether (C2H5-O-C2H5) extract of the seed of Polyalthia longifolia and were screened against fourteen pathogenic bacteria for their antibacterial activities. The test materials exhibited strong activities against most of the test bacteria. The minimum inhibitory concentration (MIC) of the compound (1) and (2) was determined against Bacillus cereus, Bacillus subtilis, Escherichia coli, Shigella flexneriae and Shigella boydii which were 64, 64, 32, 16 and 32μg ml-1 for compound (1) and 16, 32, 8, 4 and 16 μg ml-1 for compound (2), respectively. The cytotoxic activity of the compound (1) and (2) was determined by brine shrimp lethality bioassay. Both the compounds showed significant cytotoxic activities and LC50 values of Kolavenic acid (1) and 16-oxo-cleroda-3, 13(14)E-diene-15-oic acid (2) were 3.16 and 2.52μg ml-1, respectively.
  A. S. M. Anisuzzaman , Naoki Sugimoto , M. S. A. Bhuiyan , Golam Sadik and M. A. Gafur
  The chloroform extract and the two novel compounds streptmysone-A (I) and streptomysone-B (II) of the Czapek-Dox (alkaline) culture filtrate of the Streptomyces species were studied for cytotoxic and acute toxicity activities. The cytotoxic activity of the compounds and the extract was determined by brine shrimp lethality bioassay while the acute toxicity study was performed on Swiss albino mice. The LC50 values of chloroform extract(CHCl3), compound (I) and (II), and standard ampicillin trihydrate were found to be 3.89, 6.31, 125.8 and 6.31Fg ml-1, respectively. The LD50 values were found to be 66.34 and 79.49mg kg-1 for the compound (1) and (II), respectively.
  Zakia Sultana Sathi , A. S. M. Anisuzzaman , Golam Sadik and M. A. Gafur
  The subacute toxicity study of an antimicrobial compound, 4-hydroxy nitrobenzene isolated from a Streptomyces species was carried out on long Evan’s rats. The compound, 4-hydroxy nitrobenzene (300μg) was administered daily for 14 days and its effect on body weight, hematological and biochemical parameters of blood was investigated. There was no significant difference between weight gain in rats, receiving compound and control (121±5.10 vs 115±7.2g, respectively). There were no significant changes detected in hematology (red blood cells, 5.63±0.23 vs 4.97±0.17; white blood cells, 12575±170.78 vs 10950±238; platelet, 312500 ± 9574 vs 31000±21602 (cells ml-1)x106; hemoglobin, 13.25±0.3 vs 13.27 ±0.36%, for experimental and control rats, respectively) or blood biochemistry (serum glutamic oxaloacetic transaminase, 11.5±1.29 vs 11.75±1.25IU L-1, serum glutamate pyruvate transaminase, 8.25±1.26 vs 7.25±1.5IU L-1, serum alkaline phosphatase 41.25 ±1.89 vs 44.25 ± 3.3IU L-1. Uric acid, 7.05±0.129 vs 7.3± 0.22; urea, 42.25 ± 1.708 vs 41.5 ± 2.64; creatinine, 0.85±0.05 vs 1.07±0.188mg dL-1, for experimental and control rats, respectively). Therefore, the compound, 4-hydroxy nitrobenzene (300μg day-1) over 14 days, had no toxic effects on rats.
  A. S. M. Anisuzzaman , Naoki Sugimoto , S. A. Bhuiyan , Golam Sadik and M. A. Gafur
  The objective of this investigation is to determine the in vitro antimicrobial activity of the two novel compounds from Streptomyces. This antagonistic micro-organism was isolated and identified on the basis of morphological and biochemical study from the soil of the Northern district of Pabna, Bangladesh. The organism yielded maximum antimicrobial principle when grown at Czapek-Dox broth medium of pH 8 for 8 days at temperature 37.5C having rhamnose as carbon source. The antimicrobial principles were extracted from the fermentation broth by choloroform. The extract on chromatographic resolution yielded two antimicrobial compounds: Streptomysone-A (I) and Streptomysone-B (II). Both the compounds were screened for antimicrobial activity against eighteen pathogenic organisms which showed moderate to strong antimicrobial activity. The minimum inhibitory concentration (MIC) of the compounds against five pathogenic organisms were found to be between 32 to 128μg ml‾1.
  A.S.M. Anisuzzaman , Naoki Sugimoto , Golam Sadik and M.A. Gafur
  The sub-acute toxicity studies of 5-Hydroxy-2 (Hydroxy-methyl) 4H- pyran-4 one, a metabolite of Aspergillus fumigatus was carried out in rats. The compound was administered at a dose of 300 μg/rat/day for 21 days. The gross general observation such as changes of body weight, hematological profiles, biochemical parameters of blood and the histopathology of the liver, kidney, heart, lung, spleen were investigated both in control and experimental rats. The body weights of the rats were slightly increased. The change of hematological and biochemical parameters were statistically insignificant. No abnormalities were found in the histopathology of the liver, kidney, heart, lung and spleen in the experimental group of rats when compared with control group of rats.
  Robiul Islam , A.H.M. Khurshid Alam , B.M. Rahman , K.A. Salam , Aslam Hossain , Abdullahil Baki and Golam Sadik
  The sub-acute toxicities of two compounds 3,4-dimethoxycinnamyl alcohol (1) and 3,4,5-trimethoxycinnamyl alcohol (2) isolated from the plant Loranthus globosus Roxb were studied on long Evan’s rats. The studies included the gross general observation such as changes in body weight, haematological profiles [total count of Red Blood Cells (RBC) and White Blood Cells (WBC), differential count of WBC, platelet count and Haemoglobin (Hb) %], biochemical parameters of blood [Serum Glutamate Oxaloacetate Transaminase (SGOT), Serum Glutamate Pyruvate Transaminase (SGPT), Serum Alkaline Phosphatase (SALP), urea and creatinine) and histopathology of the liver, kidney, heart and lung of both control and experimental groups of rats. The changes in haematological and biochemical parameters were statistically not significant after the administration of compounds 1 and 2 in a dose of 300 μg/rat/day for consecutive 14 days. No abnormality was found in the histopathology of the liver, kidney, heart and lung in the experimental groups of rats following same dose when compared with control group. This preliminary study suggests that the isolated compounds may be used safely for clinical trial.
  M. Shah Alam Bhuiyan , Yuji Ito , Naotaka Tanaka , Golam Sadik , Kiyotaka Fujita , Atsuko Nakamura , M. Helal U. Biswas , Hiroshi Fukui and Kaoru Takegawa
  In order to obtain more insights into the molecular mechanisms of action of polyene antibiotics in yeast cells, a number of nystatin sensitive mutants of Saccharomyces cerevisiae were isolated by ethylmethane sulfonate mutagenesis. The mutants were characterized in terms of their sensitivity test to stresses such as high temperature or high concentration of monovalent and divalent cations. The invertase overlay assay method suggests that some of these mutants are defective for vacuolar protein sorting. By tetrad analysis four of these mutants were found to possesses single gene mutation.
 
 
 
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