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Articles by Gillian M. Mackay
Total Records ( 1 ) for Gillian M. Mackay
  Gillian M. Mackay , Caroline M. Forrest , Stuart R. Gould and Trevor W. Stone
  Kynurenines are tryptophan metabolites which include an agonist (quinolinic acid) and an antagonist (kynurenic acid) at glutamate receptors on intrinsic myenteric neurons. We have reported raised kynurenine and kynurenic acid in patients with inflammatory bowel disease, raising the possibility of using drugs to modulate the pathway. We have now measure etc. Despite a significant difference in the colitis activity index between active and remission phases, there were no significant differences in the levels of neopterin, kynurenines or lipid peroxidation products. Thus, a change in immune status may not be involved in the transition from active disease to remission, nutritional or endocrine factors may be important. The kynurenine pathway does not appear to be an appropriate target for drug development in this condition.
 
 
 
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