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Articles by Ghollam-Reza Moshtaghi-Kashanian
Total Records ( 3 ) for Ghollam-Reza Moshtaghi-Kashanian
  Farzaneh Esmaeili , Gholamreza Sepehri , Ghollam-Reza Moshtaghi-Kashanian , Mohammad Khaksari , Najme Salari and Ehsan Sepehri
  Problem statement: Artemisia Persia (AP) used for its therapeutic effects in folk medicine whiles some species of Artemisia shown a hypotensive effect. To determine the cardiovascular effect of AP, we tested the pharmacological responses of aqueous and methanolic extracts of AP on blood pressure (BP) and Heart Rate (HR) of normotensive and ephedrine induced hypertensive rats using a tail-cuff computerized registering device.
Hypertension was produced by single dose of ephedrine (40 mg kg-1 IM-1) to raise BP 20-30 mmHg. Animals were fed with different concentrations of each extracts (300, 400 and 500 mg kg-1) by gavage method. BP and HR were recorded before and during 40 min following aqueous and methanolic extracts administrations in 5 min intervals.
The most effective concentration of both extracts to reduced systolic BP of normotensive rats was 400 mg kg-1 after 20 min consumption (p<0.005), while none of administrated doses affected diastolic BP or HR. The efficacy of extracts was tested in hypertensive rats and the results were compared with the effect of enalapril (30 mg kg-1).
Oral consumption of AP extracts after 20 min reduced systolic BP in normotensive and hypertensive rats,while the aqueous extract of AP reduced the BP of hypertensive rats more effectively than enalapril. Hence precaution should be taken when this herb is consumed as a remedy.

  Gholamreza Sepehri , Mohammad Pourranjbar , Ghollam-Reza Moshtaghi-Kashanian , Ali Siahposht Khachaki and Ehsan Sepehri
  Problem statement: There are controversies about the effects of anti-inflammatory drugs on exercised induced changes on plasma cytokines in untrained male athletes, so the primary purpose of this study was to measure the influence of a prophylactic dose of ibuprofen use on plasma cytokines during a 1500 m running race. Approach: Subjects were 10 untrained male Medical University students who consumed 400 mg ibuprofen two hours before the 1500 m running practice and 10 controls that competed in the race but avoided ibuprofen and all other medications. Blood samples were collected before, 1h and 24 h following the 1500 m exercise bout to measure plasma concentrations of interleukin-1 beta (IL-1β), interleukin-6(IL-6) and tumor necrosis factor alpha (TNF- α). Results: There were not any significant differences between plasma concentration of IL-1β, IL-6 and TNF- α during the study period. Also the data showed that there were not any significant differences between plasma level of IL-1β, IL-6 and TNF- α in ibuprofen and control group during the study period. Conclusions/Recommendation: Our result showed that a prophylactic dose of ibuprofen did not affect acute inflammatory cytokines levels (IL-1β, IL-6 and TNF- α) in untrained healthy young males. So the etiology of the muscle soreness in athletes actively participating in sport races seems to be independent of inflammatory processes.
  Farzaneh Esmaeili , Ghollam-Reza Moshtaghi-Kashanian and Mohammad Hassannejad
  Consumption of unsaturated fatty acids could affect the immune response to oxidative or bacterial challenge. To evaluate the protective effect of dietary oils on immune system, female rats were fed for 6 weeks either with 25 or 210 mg/kg of corn or olive oils, followed by acute lipopolysaccharide (100 and 200 μg/kg) challenge. The cytokines (IL-4, IL-10 and IFN-γ) productions were evaluated and the values were compared with the corresponding results obtained for the untreated rats. Following low dose of LPS challenge, production of IL-4 and IL-10 were higher among the animals consumed oils (p<0.05) while production of IFN-γ was lower following septic shock (p<0.05). These observations may suggest consumption of corn or olive oil could have protective effects by production of pro-inflammatory cytokines. Furthermore, use of unsaturated fatty acids presented in these oils might be useful therapies in acute or chronic inflammatory diseases.
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