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Articles by Ghafour Mousavi
Total Records ( 6 ) for Ghafour Mousavi
  Daryoush Mohajeri , Ghafour Mousavi , Mehran Mesgari , Yousef Doustar and Mir Hadi Khayat Nouri
  The medicinal properties attributed to Crocus sativus L. (saffron) are extensive. The safety of saffron is important in relation to its medicinal applications. This study was performed to elucidate the possible toxic effects of ethanolic extract of Crocus sativus L. stigma on liver, kidney and some hematological parameters in rats. Wistar rats were randomly assigned into four groups of eight animals each. Group 1 was treated with ISS as control and Groups 2 to 4 were treated with extract administered daily for 2 weeks intraperitoneally in doses of 0.35, 0.70 and 1.05 g kg-1, respectively. Body weight of the animals were recorded on the first, seven and final days of the experiment. The haematological studies include total RBC count, total WBC count, Hb, %HCT, MCV, MCH and MCHC. Biochemical/serum profile studies include ALT, AST, urea, uric acid and creatinine. Tissue specimens of the liver and kidneys were subjected to histological examination using standard hematoxyline-eosin staining. The extract caused significant reductions in the Hb and HCT levels and total RBC count, although it showed any dose-dependent effect. Total WBC count showed significant dose-dependent increases in extract treated rats. Significant dose-dependent increased values of AST, ALT, urea, uric acid and creatinine were seen. Microscopically, there were mild to severe hepatic and renal tissue injuries supporting the biochemical analysis. The results indicated that extract of Crocus sativus L. stigma is toxic in high doses.
  Yousef Doustar , Daryoush Mohajeri , Alireza Garjani , Ghafour Mousavi and Mehrdad Neshat Ghramaleki
  The heart failures following infarctions is one of the most important causes of death throughout the world. This study was undertaken to investigate the protective effects of metformin on apoptotic cell death of cardiomyocytes during experimental cardiac Ischemia-Reperfusion (IR) in rats. The 25 male Wistar rats were randomly assigned into 5 groups of 5 animals each including; Sham/IR, IR, low dose metformin+IR, average dose metformin+IR and high dose metformin+IR. Heart muscle ischemia was induced clamping the left descending coronary artery. After 30 min of ischemia, the clamps were taken off and the animals underwent 2 h reperfusion. Metformin (5, 10 and 20 μg/kg/min) was infused 15 min prior to reperfusion through jugular vein in treatment groups. At the end of experiment, the rats were euthanized and histological sections from left ventricles were prepared through Tunnel Staining method. Apoptotic cells were counted under light microscope. The data obtained were statistically analyzed using ANOVA. Differences were considered statistically significant at p<0.05. In group 2, ischemia-reperfusion caused occurrence of apoptotic cell death in cardiomyocytes. There was a significant increase in the incidence rate of apoptosis of cardiomyocytes in comparison with group 1 (p<0.001). In groups 3-5 metformin (5, 10 and 20 μg/kg/min) caused significant decrease in the number of apoptotic cells in comparison with group 2 (p<0.05, p<0.01 and p<0.001, respectively). This study therefore, suggests that metformin may be a useful agent for the prevention of Ischemia-Reperfusion (IR) induced apoptotic cell death of cardiomyocytes in a dose dependent manner in the rats.
  Daryoush Mohajeri , Ghafour Mousavi and Yousef Doustar
  Adequate characterization of hypoglycemic effect of ethanolic saffron extract has not been yet done, though the activity has been reported. The scientific evaluation of its hypoglycemic activity was, therefore, explored and compared with the effect of a standard hypoglycemic drug, tolbutamide. In this study, we also report on alteration in patterns of pancreatic islet cells using histopathology and immunohistochemistry of alloxanized diabetic rats treated with ethanolic saffron extract. The ethanolic extract of Crocus sativus L. stigma was administered orally and intraperitoneally at different doses (20, 40 and 80 mg kg-1) to normal rats for finding the more effective hypoglycemic dose and administration route. Acute hypoglycemic effects produced by more effective dose of ethanolic saffron extract on the Fasting Blood Glucose (FBG) levels and effects of the same dose of ethanolic saffron extract on the FBG and plasma insulin levels in alloxanized Mild Diabetic (MD) and Severely Diabetic (SD) rats were assayed. Histopathological and immunohistochemical studies were also carried out on pancreatic islet cells of control and diabetic rats. The dose of 40 mg kg-1 was found to be more effective dose in intraperitoneally (i.p.) route for decreasing Blood Glucose Level (BGL). The extract administered by i.p. route at more effective dose showed an acute hypoglycemic effect in MD and SD rats. Treatment of MD and SD rats for 14 days with the more effective dose significantly reduced the FBG levels in these animals (41.4% MD, 30.7% SD). Serum insulin level showed significant increase in diabetic rats (33.3% MD, 27.3% SD) after 14 days. The histopathological studies of pancreas in ethanolic extract treated diabetic groups showed a reversed damage caused by alloxan to the pancreatic islets as almost normal appearance. In addition, diabetic (MD and SD) rats showed obvious decreases in insulin immunoreactivity and the number of β-cells in pancreas, but the pancreas of extract-treated diabetic rats was improved and the number of immunoreactive β-cells was significantly increased. The control group given saffron extract was not different from the other intact control group considering the insulin immunoreactivity in β-cells. The findings of present study indicate the hypoglycemic and potential antihyperglycemic nature of the extract, helping in regeneration of damaged pancreas in experimental diabetes. Thus, after randomized clinical trials, saffron extract may be implicated as a preventive or therapeutic agent against diabetes mellitus.
  Ali Rezaie , Babak Lotfollahi , Daryoush Mohajeri , Ghafour Mousavi , Mehrdad Nazeri , Solmaz Zakhireh and Babak Mohammadi
  Acceleration in healing of surgical skin wounds, in order to reduction of post-operation consequences is most important. One of the most popular compounds used ever for skin care is lavender oil or Lavandula stoechas essential oil. The aim of this study was evaluate the healing effects of Lavandula stoechas extract in comparison with zinc oxide ointment on full thickness experimental open surgical skin wound healing in the rats. For this purpose, 75 female Wistar rats were randomly assigned in 5 groups of 15 animals each including: Control, treated by Eucerin as the placebo, treated by zinc oxide topical ointment and two remaining as test groups which received 10 and 20% Lavandula stoechas extracts. Under the general anesthesia and analgesia circumstances, a full thickness incisional open wound with 23 mm diameter was made on the skin of the back part of the rats. The healing process was studied macroscopically and microscopically at 0 (the day of surgery) 3, 7, 14, 21 and 28th days of experiment in all of the rats. The greatest degree of wound contraction was considered in Lavandula stoechas extract (10%) treated rats while this change was slighter in control group. In microscopic examination, the overall healing process of Lavandula stoechas extract (10%) treated rats was significantly better than the other experimental groups (p<0.05). The results obtained showed that Lavandula stoechas extract (10%) has more effective healing properties on full thickness open skin wounds compared to zinc oxide topical ointment.
  Ali Rezaie , Behboud Jafari , Ghafour Mousavi , Mehrdad Nazeri , Amirreza Ebadi , Changiz Ahmadeh and Elmira Habibi
  In the present study, sedative and anti-anxiety drugs such as chemical drugs are used for the sedation and anti-anxiety but due to their side effects and economical issues, the significance of research on finding sedative and anti-anxiety drugs with less side effects and their ability to substitute these synthetic drugs and substituting newer sedation and anti-anxiety compounds is obvious. Origanum majorana is one of the plants that have the effect sedation and anti-anxiety. The aim of this research was to examine the effects of sedative, pre-anesthetic and anti-anxiety of Origanum majorana with diazepam in rats to different groups of male Wistar rats received herbal extract Origanum majorana with doses (100, 200, 400 mg kg-1, IP) and diazepam with dose of (1/2 mg kg-1, IP) and dimethyl sulfoxide with the equal volume. About 30 min after assessing the relift/sleep inducing effect (induced sleep duration by ketamine 40 mg kg-1, IP) anti-anxiety effects (using elevated plus maze). The results show meaningful increase in the period of the sleep that had been made with ketamine and also meaningful increase in the spend time at open arms in the patient group with the previous. The results show that the dose of extract Origanum majorana 200 mg kg-1 relieving effects of sedative, pre-anesthetic and anti-anxiety and before.
  Daryoush Mohajeri , Ghafour Mousavi and Mehrdad Nazeri
  The thyroid gland in most animal species has two lobes, one on each lateral surface of the trachea. In pigs, the main lobe of the thyroid gland is on the midline in the ventral cervical region with dorsolateral projections from each side. The thyroid structural changes in gouts were investigated. About 386 pairs of thyroid glands collected from gout at the local municipal abattoir in Tabriz city of East Azerbaijan province. A total of 386 thyroid specimens examined, 8 cases were follicular atrophy, 4 cases were thyroid fibrosis, 71 cases were diffuse hyperplasia of thyroid follicular cells, 5 cases were colloid goiter, 10 cases were parenchymal cysts, 3 cases were nodular hyperplasia, 1 case was C-cell adenoma and 1 case was C-cell carcinoma.
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