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Articles by Gerald N. Teke
Total Records ( 1 ) for Gerald N. Teke
  Gerald N. Teke , Paul K. Lunga , Hippolyte K. Wabo , Jules-Roger Kuiate and Jean P. Dzoyem
  The stem bark of E. abyssinica is used in traditional medicine for the treatment of diarrhoea in west region of Cameroon. To substantiate this folkloric claim, the methanol extract, fractions and isolated compounds from E. abyssinica stem bark were investigated for their antidiarrhoeal activities in Wistar albino rats. The methanol extract of E. abyssinica stem bark was pre-dissolved in a mixture of methanol and water and partitioned into n-hexane, ethyl acetate and n-butanol fractions. The ethyl acetate portion was fractionated by column chromatography and the structures of isolated compounds elucidated by spectroscopic analyses in conjunction with literature data. Antidiarrhoeal activity was investigated in terms of purging index, consistency of faeces and intestinal transit in castor oil induced diarrhoea, and faecal Shigella load, faecal frequency, variation in bodyweight and blood chemistry in Shigella-induced diarrhoea model in Wistar rats. Two known compounds [(5S,6R,8aR)-5-(carboxymethyl)-3,4,4a,5,6,7,8,8a-octahydro-5,6,8atrimethylnaphthalenecarboxylic acid (1), methyl 3,4,5-trihydroxybenzoate (2) were isolated. The methanol extract, fractions and isolated compounds showed antidiarrhoeal activities evidenced by the reduction in % respondent to diarrhoea, a delay in the period for diarrhoea induction, reduction in purging index and wateriness of faeces. Compounds 1 and 2 inhibited diarrhoeal droppings by 81.01 and 87.34%, respectively. Compared to the methanol extract, fractionation increased the shigellocidal activity with ethyl acetate fraction most active. The experimental findings show that the methanol extract, fractions and isolated compounds from E. abyssinica stem bark possess significant antidiarrhoeal activities justifying the traditional use of this plant in diarrhoeal treatment and may be developed as phytomedicine.
 
 
 
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