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Articles by Georgi Momekov
Total Records ( 2 ) for Georgi Momekov
  Irena Kostova and Georgi Momekov
  Complexes of cerium(III), lanthanum(III) and neodymium(III) with 3,5-pyrazoledicarboxylic acid (H3pdc) were synthesized and their compositions determined by elemental analysis. To identify the binding of Ce(III), La(III) and Nd(III) with H3pdc, detailed vibrational analysis was performed comparing experimental vibrational spectra of the ligand and its Ln(III) complexes with theoretically predicted and with literature data from related compounds. Significant differences in the IR and Raman spectra of the complexes were observed as compared to spectra of the ligand. The ligand and the complexes were tested for cytotoxic activities on the chronic myeloid leukemia derived K-562, overexpressing the BCR-ABL fusion protein and the non-Hodgkin lymphoma derived DOHH-2, characterized by an overexpression of the antiapoptotic protein bcl-2 cell lines. The results indicate that the tested compounds exerted considerable cytotoxic activity upon the evaluated cell lines in a concentration dependent manner; we constructed dose-response curves and calculated corresponding IC50 values. The lanthanide complexes exhibited potent cytotoxic activity, even more than cisplatin towards K-562 and DOHH-2 cell lines. In order to elucidate some of the mechanistic aspects of the observed cytotoxic effects, we evaluated whether the established cytotoxicity of the most active complex La(H2pdc) is related to its capacity to induce cell death through apoptosis.
  Ilina Krasteva , Stefan Platikanov , Georgi Momekov , Spiro Konstantinov and Stefan Nikolov
  The volatile fractions from Astragalus corniculatus Bieb., cultivated and collected wild, were analyzed at three different phenological phases for the first time. GC/MS analysis showed that the volatile fractions contain hydrocarbons, butyl ethers, acids, alcohols, esters, aldehydes, ketones, terpenes. These fractions were tested for cytotoxic activity in a panel of human tumor cell lines after 48 h, using the MTT-dye reduction assay. Throughout the cytotoxicity evaluation the fraction derived from the flowering phase of wild type plant was found to exert the most prominent cytotoxic activity, which could be ascribed to the high content of hydrocarbons and squalene in particular. Furthermore, the mechanistic elucidation of the mode of action of this volatile fraction in SKW-3 cells revealed that the observed activity is mediated by induction of necrotic type cell death as evidenced by the smear patterns of DNA following a 24 h exposure period.
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