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Articles by Gamal A. Soliman
Total Records ( 9 ) for Gamal A. Soliman
  Ahmed I. Foudah , Aftab Alam , Gamal A. Soliman , Mohammed Ayman Salkini , Elmutasim O. Ibnouf Ahmed and Hasan S. Yusufoglu
  The study was designed to investigate the pharmacognostic parameters of the aerial parts as well as antimicrobial and antioxidant activities of methanol extract of Pulicaria somalensis O. Hoffm (MEPS). These studies were carried with a view to justify the future use of this plant. This study deals with the morphological, microscopical studies of leaf, aerial part of P. somalensis, along with the physicochemical and preliminary phytochemical analyses that were also studied. The antibacterial activities were tested against both Gram-positive and Gram-negative bacteria while antifungal activities were tested against Aspergillus niger and Candida albicans using the agar disc diffusion method. The zone of inhibition was compared with standard (Ampicillin). The study of in vitro antioxidant was performed by using DPPH and FRAP assays. The results of the present morphological study correlated with earlier reports. The microscopical and physicochemical finding explores the useful identification character for authentication of this plant. The preliminary phytochemical study showed the presence of phenol, tannins and flavonoids types of active drugs. The marked antibacterial, antifungal and antioxidant were observed, which may be due to the presence of active constituents present in MEPS. The outcome of the present findings suggested that the plant may be a good source of antibacterial and antioxidant. The present finding concluded the in vitro activities, so it needs to be explored more in vivo evaluation before adding it into the world of medicinal plants.
  Hasan S. Yusufoglu , Gamal A. Soliman , Rehab F. Abdel-Rahman , Maged Saad Abdel-Kader , Majid A. Ganaie , Erdal Bedir , Sura Baykan and Bintug Ozturk
  In the present study, DPPH radical scavenging assay and ferric-reducing antioxidant assay were used to evaluate in vitro antioxidant potential of the methanol extract of Ferula duranii (F. duranii). The antihyperglycemic and antihyperlipidemic activities of F. duranii extract were evaluated in streptozotocin (STZ)-induced diabetic rats. F. duranii showed considerable antioxidant potential in the DPPH radical scavenging assay and minimum reducing power in ferric-reducing antioxidant power assay. A meaningful reduction in the concentrations of Fasting Blood Glucose (FBG), glycosylated hemoglobin (Hb A1c), triglycerides (TG), Total Cholesterol (TC) and Low Density Lipoprotein (LDL-C) in plasma and an elevation in the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) in hepatic and pancreas homogenates were observed in diabetic animals medicated with F. duranii extract in comparison with diabetic control rats. The level of insulin raised significantly in plasma of diabetic groups received F. duranii in respect to diabetic control one. Levels of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), bilirubin, total protein and High Density Lipoprotein (HDL-C) in plasma and malondialdehyde (MDA) in liver and pancreas homogenates were recovered significantly in F. duranii-medicated diabetic rats in comparison with diabetic controls. The present data suggest that F. duranii has both antidiabetic and antihyperlipidemic effects.
  Hasan S. Yusufoglu , Gamal A. Soliman , Ahmed I. Foudah , Maged S. Abdulkader , Mohammed H. Alqarni , Aftab Alam and Mohammad Ayman Salkini
  Background and Objective: Arnebia hispidissima (A. hispidissima) a member of the family Boraginaceae, is dye yielding and medicinally important plant. It is widely used in the cosmetic industries. This study has been made for the preliminary standardization of A. hispidissima plant. Methodology: The standardization evaluation comprises of powder microscopy and fluorescence analysis and TLC profiling. In addition, preliminary phytochemical screening, determination of total phenol and in vitro free radical scavenging activity (DPPH radicals scavenging assay and reducing power activity) were preformed utilizing the methanol extract. Results: A microscopic study of powder of whole plant of A. hispidissima showed different types of trichomes, vessel and fibres. Fluorescence analysis showed different colours under visible light, low UV and high UV. TLC of the hexane extract developed 8, 6, 9 and 10 spots with visible light, low UV, high UV and ninhydrin-H2SO4 spray, respectively. The phytochemical analysis of the methanol extract gave a positive indication for the presence of active compounds including alkaloids, carbohydrates, glycosides, steroids, triterpenoids saponins, phenols, tannins, flavonoids and proteins. The quantitative analysis showed the presence of a significant quantity of total phenol and the in vitro antioxidant activity clearly showed the terrific antioxidant property. Conclusion: The data generated from the present study can be utilized for the identification and quality control of A. hispidissima plant.
  Hasan S. Yusufoglu , Gamal A. Soliman , Ahmed I. Foudah , Maged S. Abdulkader , Hossny A. El-Banna , Aftab Alam and Mohammad Ayman Salkini
  Background and Objective: Arnebia hispidissima (F. Boraginaceae) has been found to have cardiac and febrifuge properties. It has long been used in traditional system of medicine for the treatment of heart ailments, headache and fever. This study aimed to investigate the protective effect of Arnebia hispidissima extract (AHE) on carbon tetrachloride (CCl4)-induced cardiotoxicity and nephrotoxicity. Materials and Methods: Adult rats were divided into five groups and medicated as follows: (1) The control group received the vehicles (olive oil; 1 mL kg–1, i.p.+3% Tween 80; 1 mL kg–1, p.o.). (2) CCl4 group of animals was administered with 20% CCl4 in olive oil (1 mL kg–1, p.o.). (3) Silymarin group was co-administered with CCl4 plus silymarin (50 mg kg–1, p.o.). (4) CCl4 plus AHE (200 mg kg–1, p.o.). (5) CCl4 plus AHE (400 mg kg–1, p.o). Rats received vehicle, CCl4, silymarin or AHE twice a week for 8 weeks. Serum AST (aspartate transaminase), LDH (lactate dehydrogenase), CK (creatine kinase), CK-MB (creatine kinase-MB isoenzyme) and cTnI (cardiac troponin) were measured to assess the heart damage markers. Serum levels of creatinine, urea, uric acid and BUN (blood urea nitrogen) were measured as markers of the renal function. Markers of oxidative stress in the cardiac and renal tissues were estimated by determining the levels of SOD (superoxide dismutase), GPx (glutathione peroxidase), CAT (catalase), GSH (reduced glutathione) and MDA (malondialdehyde). Heart and kidney tissues were investigated for histopathological changes. Results: Administration of CCl4 significantly increased the levels of cardiac and renal damage markers. Co-administration of CCl4 plus AHE significantly relieved the adverse effect of CCl4 in rat and reduced the increased serum levels of cardiac and renal damage markers. AHE compensated the deficits in the antioxidant defense mechanisms (SOD, GPx and CAT) and suppressed LPO (lipid peroxidation) in rat heart and kidney resulting from CCl4 administration. Moreover, histopathological changes induced with CCl4 in heart and kidney tissues of rat were also reduced with the co-administration of AHE. Conclusion: In this study, we have found that oral administration of AHE prevented CCl4-induced cardio- and nephrotoxicity by accelerating heart and kidney antioxidant defense mechanisms and down regulating the LPO near to the normal levels.
  Hasan Yusufoglu , Gamal A. Soliman , Rehab F. Abdel-Rahman and Ozgen Alankus-Caliskan
  The objective of this study was to investigate the potential hepatoprotective effect of the ethanol extracts of Astragalus kurdicus Boiss. var. kurdicus (A. kurdicus) and Astragalus cinereus Willd. (A. cinereus) in a rat model of paracetamol (PCM) induced liver damage. Paracetamol administration caused severe hepatic damage in rats as evidenced by elevated serum activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), γ-glutamyl transferase (γ-GT) and serum level of total bilirubin (BRN) while decreased serum levels of total protein (TP) and albumin (ALB). In liver homogenates, PCM elevated malondialdehyde (MDA) but decreased glutathione (GSH) levels as well as glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) activities. Administration of A. kurdicus and A. cinereus extracts (200 and 400 mg kg–1) for 7 days before PCM inhibited the elevation of the serum activities of ALT, AST, ALP and γ-GT enzymes and serum level of BRN. Moreover, they elevated the serum level of TP. Paracetamol-induced lipid peroxidation was also reduced by both extracts. Likewise, both extracts increased the activities of the antioxidant enzymes (GPx, SOD, CAT) in the liver homogenates and reduced GSH concentration. The results of the in vitro antioxidant effect revealed marked antioxidant activity for both extracts. The histopathological analysis suggested that both extracts obviously alleviated the degree of liver damage due to PCM administration. The present study suggests that A. kurdicus and A. cinereus possess hepatoprotective activities that could be partly attributed to their antioxidant effects.
  Gamal A. Gabr , Gamal A. Soliman , Saeedan S. Abdulaziz , Abdullah A. Al- Kahtani and Bahaa E. Ali
  Exposure to insecticides is most considerable due to their untoward effects on the production and reproduction in human and animals. The aim of our study was to assess the teratogenic potential of Emamectin benzoate (EMB) insecticide in rats. Pregnant rats were separated into four equal groups; the first one kept as a control group. The 2nd, 3rd and 4th groups were orally administered EMB on Gestation Day (GD) 6 through GD 15 at doses of 4.4, 8.8 and 17.6 mg kg–1 day–1, respectively. All pregnant rats were exposed to caesarean section on GD 21 and their fetuses were examined for morphological, visceral and skeletal abnormalities. Decreased maternal weight gain, fetal and placental weight and number of viable fetuses and elevated rate of fetal resorptions and post-implantation deaths were recorded in groups exposed to EMB at 8.8 and 17.6 mg kg–1. The percentage of morphological, visceral and skeletal abnormalities were significantly increased in the fetuses of dams of EMB-exposed rats at 8.8 and 17.6 mg kg–1. The retardation in growth of viable fetuses, hydrocephaly, an ophthalmia, lung hypoplasia, incomplete ossification of cranial bones, aplasia of metacarpals, metatarsals, phalanges and caudal vertebrae were the important fetal anomalies. The present study concluded that EMB is teratogenic when given orally to pregnant rats.
  Hasan S. Yusufoglu , Gamal A. Soliman , Rehab F. Abdel- Rahman , Maged Saad Abdel-Kader , Majid A. Ganaie , Erdal Bedir , Sura Baykan Erel and Bintug Ozturk
  The present study was carried to explore the potential antihyperglycemic and antihyperlipidemic activity of Ferula assa-foetida L. and Ferula tenuissima Hub-Mor & Pesmen extracts in streptozotocin (STZ) induced diabetic rats. Furthermore, phytochemical screening, in vitro antioxidant activity and acute toxicity study of both plants were performed. Both extracts showed considerable antioxidant potential in vitro. In diabetic rats, F. assa-foetida (200 and 400 mg kg–1) and F. tenuissima (400 mg kg–1) showed significant elevation in plasma insulin level, total hemoglobin (Hb) and decrease in Fasting Blood Glucose (FBG) and glycosylated hemoglobin (HbA1c) levels. Significant elevations in the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and level of reduced glutathione (GSH) in liver and pancreas homogenates were observed in diabetic animals following F. assa-foetida (200 and 400 mg kg–1) and F. tenuissima (400 mg kg–1) treatments. The antihyperlipidemic effect of F. assa-foetida extract was demonstrated by a significant reduction in plasma triglycerides (TG), Total Cholesterol (TC), Low Density Lipoprotein Cholesterol (LDL-C) and the increase of High Density Lipoprotein Cholesterol (HDL-C). Plasma activities of alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) and levels of Total Protein (TP) and bilirubin (BIL) in diabetic rats were recovered significantly after F. assa-foetida and F. tenuissima treatment in comparison with diabetic controls. The present data suggest that F. assa-foetida have both antihyperglycemic and antihyperlipidemic effects with enhancement of insulin-secreting activity.
  Gamal A. Soliman , Abd El Raheim M. Donia , Amani S. Awaad , Saleh I. Alqasoumi and Hasan Yusufoglu
  Context: Emex spinosa (L.) Campd. (Polygonaceae), Leptadenia pyrotechnica (Forsk.) Decne (Asclepiadaceae), Haloxylon salicornicum (Moq.) Bunge ex Bioss. (Chenopodiaceae) and Ochradenus baccatus Delile (Resedaceae) are used in folk medicine for treatment of male sexual disorders. Objective: To investigate the effects of E. spinosa, L. pyrotechnica, H. salicornicum and O. baccatus extracts on the reproductive system of male rats after prolonged period of treatment. Methods: Seventy-eight healthy adult male Wistar rats were divided into 13 groups (6 animals, each). The plant extracts (100, 200 and 400 mg/kg) were given daily by gavage to different groups of rats for 65 days. The thirteenth group (control) received the vehicle only. Test and control rats were mated with estrus female rats on days 30, 45 and 60 of treatment. Body and relative reproductive organ weights, and sperm parameters were recorded. Results: Animals treated with the ethanol extracts of E. spinosa and L. pyrotechnica showed significant improvement of the relative weight of reproductive organs, sperm count, sperm motility and total sperm abnormality. The mean sperm count for E. spinosa group (400 mg/kg) was 233.7 ± 4.50 x 106/mL, for L. pyrotechnica (200 and 400 mg/kg) groups were 237.0 ± 5.22 x 106/mL and 240.3 ± 4.64 x 106/mL, respectively and that of the control group was 218.1 ± 4.28 x 106/mL. The sperm motility of the control group was 77.5 ± 2.12, those of E. spinosa (400 mg/kg) group was 87.3 ± 3.50% and those of L. pyrotechnica (200 and 400 mg/kg) groups were 86.0 ± 3.11 and 89.7 ± 2.90%, respectively. Ethanol extracts of E. spinosa (400 mg/kg) and L. pyrotechnica (200 and 400 mg/kg) significantly elevate the serum levels of testosterone (5.30 ± 0.15, 5.32 ± 0.20 and 5.66 ± 0.19 ng/mL, respectively vs 4.64 ± 0.16 ng/mL) and luteinizing hormone (0.69 ± 0.03, 0.70 ± 0.03 and 0.74 ± 0.03 mIU/mL, respectively vs 0.59 ± 0.02 mIU/mL). On the other hand, no alterations were observed in body and relative organ weights, sperm numbers as well as sperm morphology of the male rats after the exposure to the H. salicornicum and O. baccatus extracts for 65 days. Conclusions: E. spinosa and L. pyrotechnica extracts appear to possess fertility improvement activity in male rats due to their testosterone increasing property. Moreover, the results suggest the absence of male reproductive toxicity of the H. salicornicum and O. baccatus extracts at tested doses.
  Amani S. Awaad , Gamal A. Soliman , Dalia F. El-Sayed , Omimah D. El-Gindi and Saleh I. Alqasoumi
  Objective: The present work explored the potential hepatoprotective activity of total ethanol and successive extracts of Cyperus alternifolius L (Cyperaceae) against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats and to isolate their bioactive constituents. Methods: For isolation and identification of the compounds, column chromatography and spectroscopic analysis were used, a model of hepatotoxicity by CCl4 in rats was used to evaluate the total ethanol extract and its successive fractions. Results: Phytochemical screening of C. alternifolius revealed the presence of different phytochemical groups. The plant proved to be safe for human use because it did not induce any signs of toxicity or mortality in mice when administered orally at doses up to 5000 mg kg−1. The total alcoholic extract in doses of 100 and 200 mg kg−1 and the successive extracts (ether, chloroform and ethyl acetate) in a dose of 10 mg kg−1 exhibited a significant (p ≤ 0.05) protective effect by lowering the elevated serum levels of aspartate aminotransferase: 230.4, 218.8, 224.6, 227.4 and 231.6 U L−1, respectively, compared with 111.6 U L−1 for silymarin (25 mg kg−1). Serum levels of alanine aminotransferase were also reduced: 77.4, 72.7, 79.7, 76.0 and 79.7 U L−1 compared to 63.7 U L−1 for silymarin. Alkaline phosphatase: 164.6, 158.0, 163.6, 154.7 and 166.4 U L−1 compared to 138.2 U L−1 for silymarin. Total bilirubin: 0.50, 0.46, 0.55, 0.52 and 0.57 mg dl−1 compared to 0.42 mg dl−1 for silymarin. Cholesterol: 213.1, 200.0, 192.7, 193.6 and 197.1 mg dl−1 compared to 180.3 mg dl−1 for silymarin. Triglycerides: 237.3, 222.4, 209.5, 206.8 and 210.2 mg dl−1 compared to 196.8 mg dl−1 for silymarin. Eight phenolic compounds were isolated from C. alternifolius for the first time and identified as esculetin 1, umbelliferon 2, imperatorin 3, psoralen 4, xanthotoxin 5, quercetin 6, quercetin-3-O-rutinoside 7 and gallic acid 8. Conclusions: The results concluded that C. alternifolius possesses significant protective effect against hepatotoxicity induced by CCl4.
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