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Articles by G.S. Taiwe
Total Records ( 4 ) for G.S. Taiwe
  E. Ngo Bum , M.M. Pelanken , N. Njikam , E. Talla , G.S. Taiwe , G.C.N. Nkantchoua and G.T. Ngoupaye
  The aim of this study is to scientifically look for sedative and anticonvulsant properties of the decoction of Phyllanthus discoideus Baill (P. discoideus) in mice. The in vivo models of epilepsy were used to evaluate the anticonvulsant properties of the plant. These models were maximal electroshock-, N-methyl-D-aspartate-, pentylenetetrazol-, isonicotinic hydrazide- acid and strychnine- induced convulsions or turning behavior in mice. The potentiation of sleep induced by diazepam in mice was used for the determination of the sedative properties. Four doses of the plant in the decoction were used: 17.1, 42.7, 85.5 and 171 mg kg-1. The decoction of the leaves of P. discoideus strongly increased the total sleep time (p<0.001) induced by diazepam and precipitated its onset (p<0.001). The decoction also protected mice against maximal electroshock- (p<0.001), pentylenetetrazol- (p<0.001), strychnine- (p<0.001) and N-methyl-D-aspartate- induced seizures or turning behavior (p<0.001). Finally, the decoction increased the latency to the onset of seizure in isonicotinic hydrazide acid test (p<0.001). In conclusion the decoction of P. discoideus posses anticonvulsant and sedative properties in mice. The presence of these properties could explain its use in traditional medicine in Cameroon in the treatment of insomnia and epilepsy.
  E.N. Bum , G.N. Nkantchoua , N. Njikam , G.S. Taiwe , G.T. Ngoupaye , M.M. Pelanken , Nanga , F. Maidawa , A. Rakotonirina and S.V. Rakotonirina
  Senna spectabilis DC. is a small tree, 3 to 5 m, found in tropical areas in Africa, Asia, Australia, Latino and South America. It is used in traditional medicine in Cameroon to treat many diseases (constipation, insomnia, epilepsy, anxiety, etc.). Therefore, the aim of this study was to look scientifically for the anticonvulsant and sedative properties of S. spectabilis. In vivo animal models of epilepsy (Maximal Electroshock (MES), N-Methyl-D-Aspartate (NMDA), Pentylenetetrazol (PTZ) and Strychnine (STR) induced convulsions or turning behavior) and insomnia (diazepam-induced sleep) were used. Mice were divided in six groups: one negative control group, one positive control group and four groups treated with the plant extract, (except for diazepam-induced sleep test). Four doses of the ethanolic extract were used: 100, 200, 500 and 1000 mg kg-1. The ethanolic extract of the leaves of Senna spectabilis strongly increased the total sleep time induced by diazepam (p<0.001). It also protected mice against Maximal Electroshock (MES) (p<0.01), pentylenetetrazol (p<0.001), picrotoxin (p<0.01) strychnine (p<0.01) and n-methyl-d-aspartate (p<0.001)-induced seizures and turning behavior and increased the latency to the onset of seizure in Isonicotinic Hydrazide Acid (INH) test (p<0.01). The results lead to the conclusion that the extract of Senna spectabilis possesses anticonvulsant and sedative properties in mice and could explain its used in traditional medicine in Africa, in the treatment of insomnia and epilepsy.
  G.S. Taiwe , E. Ngo Bum , T. Dimo , E. Talla , N. Weiss , A. Dawe , F.C.O. Moto , N. Sidiki , P.D. Dzeufiet and M. De Waard
  The neuropharmacological effects of the decoction of Nauclea latifolia Smith (Rubiaceae) roots were studied in mice. Different experimental models (forced swimming test, horizontal wire test and hole-board test) were used for detecting antidepressant, myorelaxant and anxiolytic properties. The results revealed that Nauclea latifolia induced a reduction of immobility, in a similar way to that of fluoxetine, along with a significant increase in the percentage of spent time in swimming behavior. Nauclea latifolia displayed a myorelaxant activity in the horizontal wire test. In the hole-board test, Nauclea latifolia significantly increased the number and duration of head-dips. In addition, anxiolytic-like properties of Nauclea latifolia were blocked by anxiogenic agents as examined in the hole-board test. This was the case for N-methyl-β-carboline-3-carboxamide (FG7142), a partial inverse agonist at the benzodiazepine site of the GABAA receptor complex, flumazenil (RO151788), a central benzodiazepine receptor antagonist and bicuculline, a light-sensitive competitive antagonist of GABAA receptors. These results suggest that Nauclea latifolia roots decoction possess antidepressant, myorelaxant and anti-anxiety-like properties in the models employed. The extracts might potentially act by GABAergic activation and/or by modulating the serotoninergic levels in the central nervous system. However, further studies were still required.
  E. Talla , B. Dabole , G.S. Taiwe , E. Ngo Bum , J.T. Mbafor , A.D.T. Atchade , R. Malik , A. Zulfiqar , N. Sidiki , R.M. Nguimbou and M.I. Choudhary
  Background: Propolis is a resinous substance that honeybees collect from different plant exudates and use to fill gaps and to seal parts of the hive. It possesses many biological activities: antinociceptive, anti-inflammatory, antibacterial, antiviral, fungicidal, antitumoral, etc. The present study was designed to evaluate the antinociceptive effects of three pentacyclic triterpenoids derivatives isolated from the Cameroonian brown propolis: lup-20(29)-en-3-one, erythrodiol palmitate and 18-iso-olean-12-ene-3,11-dione. Materials and Methods: The antinociceptive effects of the pentacyclic triterpenoids were investigated in animals employing acetic acid induced abdominal constrictions, formalin-induced nociception and the mechanical hypernociception induced by prostaglandin E2. Mice were submitted to the open-field test in order to assess any motor dysfunction and sedation or alteration in locomotor activity. The ability of these pentacyclic triterpenoids to induce cytotoxicity were further investigated by using prostate cancer (PC-3) or mouse fibroblast (3T3) cells lines and a standard 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) bioassay. Results: The pentacyclic triterpenoids isolated from propolis administered intraperitonealy produced significant antinociceptive effects in the acetic acid and formalin tests. All the triterpenoids elicited dose-dependent antinociceptive effects in mechanical hypernociception induced by intraplantar injection of prostaglandin E2. These antinociceptive effects were significantly attenuated by pretreatment with naloxone. The pentacyclic triterpenoids did not alter the locomotion of animals in the open-field tests which suggest a lack of a central depressant effect. As shown, incubation for 24 h of the PC-3 or 3T3 cells lines with the pentacyclic triterpenoids up to a concentration of 30 μM produces no cell toxicity. Conclusion: Taken together the results of this study suggest that the pentacyclic triterpenoids derivatives isolated from propolis (lup-20(29)-en-3-one, erythrodiol palmitate and 18-iso-olean-12-ene-3,11-dione) produced dose related antinociception in models of chemical nociception and mechanical hypernociception through mechanisms that involve an interaction with opioidergic pathway.
 
 
 
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