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Articles by G.O. Ajayi
Total Records ( 3 ) for G.O. Ajayi
  B. Ogunlade , L.C. Saalu , O.S. Ogunmodede , G.G. Akunna , O.A. Adeeyo and G.O. Ajayi
  Alcohol is currently recognized as the most prevalent known cause of abnormal human health. Furthermore, the liver remains the most commonly affected organs following alcohol abuse. The effect of Allium cepa against alcohol-induced hepatic damage in rabbits was investigated in the present study. Rabbits were divided into four groups; The Allium cepa-alone group received physiological saline 5 mL kg-1 b.wt., daily per oral (p.o) for 60 days followed by Allium cepa 100 mg kg-1 b.wt., daily p.o for another 60 days. The alcohol-alone group was given alcohol 5 mg kg-1 b.wt., daily p.o for 60 days followed by saline 5 mL kg-1 b.wt., daily p.o for another 60 days. The alcohol plus Allium cepa group were similarly given alcohol, but had Allium cepa 100 mg kg-1 b.wt, daily p.o post-treatment for another 60 days. Another group of rabbits were given peanut oil (the vehicle) 100 mg kg-1 b.wt., daily p.o, for 60 days, after saline 5 mL kg-1 b.wt., daily p.o for 60 days to serve as the control. The gross anatomical parameters of the liver and liver histology were assessed. Liver oxidative stress was evaluated by liver Superoxide dismutase (SOD), catalase (CAT), Glutathione Peroxidase (GPx), reduced glutathione (GSH) and malondialdehyde (MDA) assays. In addition, the activities of the biomarker enzymes of the liver (alanine transaminase, aspartate transaminase, alkaline phosphatase and gamma-glutamyl transpeptidase) were assayed. An assessment of the histological profiles of the liver showed a derangement of the liver cytoarchitecture following alcohol abuse and a marked improvement was observed after Allium cepa administration. Similarly, Allium cepa improved the reduction of antioxidant parameters (SOD, CAT, GPx and GSH) and the increased MDA and serum hepatic markers levels caused by alcohol ingestion. It was concluded that Allium cepa may offer protection against free radical mediated oxidative stress of rabbits with alcohol-induced hepatotoxicity.
  L.C. Saalu , A.A. Osinubi , P.I. Jewo , A.O. Oyewopo and G.O. Ajayi
  The therapeutic value of Doxorubicin (DOX) as anticancer antibiotic is limited by its organotoxicity. It has been shown that free radicals are involved in doxorubicin-induced toxicity. Doxorubicin causes the generation of free radicals and the induction of oxidative stress, associated with cellular injury. Because of the great importance of DOX in cancer therapy, researchers have expended great efforts trying to prevent or attenuate the side effects of DOX administration. There has, however, been only a little success in this regard. In this study the ameliorating role of antioxidant-rich ethanolic seed extract of Citrus paradisi (CP) on DOX-induced testicular oxidative stress and impaired sperm parameters was investigated. Three experimental groups of Wistar rats were used; CP-alone group that received orally CP 10 mg kg-1 b.wt. daily for 14 days followed by intraperitoneal (i.p.) Normal Saline (NS) 2.5 mg kg-1 b.wt. DOX-alone group that had ip DOX 10 mg kg-1 b.wt. as a single dose. CP plus DOX-group that were similarly given DOX, but also had oral CP 10 mg kg-1 b.wt. pretreatment for 14 days. There was also a corresponding control group. The animals were autopsied 8 weeks after DOX or NS injections. Results showed that DOX-induced reduction in sperm motility and epididymal sperm concentrations as well as increase in total abnormal sperm rates were all normalized in the group pretreated with CP. Pretreatment with CP ameliorated the testicular content of Glutathione (GSH) and Auperoxide Dismutase (SOD), Catalase (CAT) and Glutathione Peroxidase (GPx) activities. Similarly, CP treatment attenuated the DOX-induced increase in testicular lipid peroxidation reflected by malondialdehyde (MDA) levels. These data indicate that CP protects the rat testis against DOX-induced oxidative stress and deranged sperm characteristics.
  L.C. Saalu , G.O. Ajayi , A.A. Adeneye , I.O. Imosemi and A.A. Osinubi
  In the present study, we examined the ameliorating effect of the 100% ethanol extract of Citrus paradisi (grapefruit) seed (GSE) on survival of doxorubicin treated rats and on DOX- induced cardiomyopathy. Whereas only 20% of the rats treated with DOX (20 mg kg-1 body weight intraperitoneally) survived at the end of 14 days, almost all the DOX-treated rats survived when GSE (20 mg kg-1 body weight) was administered by gastric gavage. In the second experiment, GSE (20 mg kg-1 body weight) was administered daily by gavage for 14 consecutive days before a cumulative single dose of DOX (20 mg kg-1 body weight, intraperitoneally) was given. DOX induced marked biochemical alterations characteristic of cardiac toxicity. There was enhanced lipid peroxidation measured as malondialdehyde (MDA). The anthracycline antibiotic drug reduced the cardiac enzymatic activities of superoxide dismutase (SOD), glutathione S transferase (GST) and catalase (CAT). Besides, it reduced significantly the reduced glutathione (GSH) level; prior administration of grapefruit seed extract ahead of doxorubicin challenge ameliorated all these biochemical markers. Taken together, one could conclude that grapefruit seed extract has a protective role in the abatement of doxorubicin-induced cardiac toxicity that resides, at least in part, on its anti-radical effects.
 
 
 
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