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Articles by G.K. Rao
Total Records ( 2 ) for G.K. Rao
  G.K. Rao , R.B. Kotnal and P.N.S. Pai
  A novel synthetic methodology of Schiff’s bases incorporating 3-methylquinoxalin-2(1H)-one is described. The title compounds were prepared by condensation of substituted aromatic aldehydes and 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl) acetic acid hydrazide. Structures of all these compounds were confirmed by their spectral studies. These compounds were screened for in vitro antitubercular, antibacterial and antifungal activities. From the biological studies, it was possible to observe that some of the substituent on the phenyl ring of quinoxalinone hydrazones influenced the activity. Among synthesized compounds (4f, 4g, 4i and 4j), have shown good anti tubercular activity (25 μg mL-1) when compared to reference drug. Compounds (4g and 4j) showed moderate to good antimicrobial activity at low concentration. The MICs (Minimum Inhibitory Concentration) against gram positive, gram negative and some species of fungi are in the range 2-4 μg mL-1 when compared to standard drug. In conclusion, the antimicrobial testing results revealed that the compounds possess broad spectrum of in vitro antimicrobial activity at low concentration. The ambient conditions, excellent product yields and easy workup procedures make this methodology a better protocol for the synthesis of newer derivatives.
  K. Ranjit , G.K. Rao and P.N.S. Pai
  A novel synthetic methodology of Schiff bases incorporating dibenzazepine carbohydrazide with isatin is described. The title compounds were prepared by condensation of carbohydrazide and substituted isatins. Structures of all these compounds were confirmed by their spectral studies. These compounds were screened for their in vitro antioxidant activity. From the biological studies, it was possible to observe that some of the compounds have shown good antioxidant activity when compared to the standard, ascorbic acid. Compounds with electron withdrawing substitutents (3f) and (3k) have shown better activity at lowest concentration than electron donating substitutents. The ambient conditions, good product yields and easy work up procedures make this methodology a better protocol for the synthesis of newer derivatives which can be explored further for biological activities.
 
 
 
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