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Articles by G.K. Ainooson
Total Records ( 2 ) for G.K. Ainooson
  E. Woode , E. Boakye-Gyasi , G.K. Ainooson , C. Ansah and M. Duwiejua
  The anti-nociceptive effect of an ethanolic leaf extract of Palisota hirsuta, a plant used locally in Ghana for various painful conditions was assessed, using various pain models. Palisota hirsuta extract (PHE) together with morphine and diclofenac (positive controls), all showed significant dose-dependent anti-nociceptive activity in all the models used, that is the tail withdrawal test, the inflammatory-induced mechanical hyperalgesia test, the acetic acid induced writhing test and the formalin test. The anti-nociceptive effect exhibited by PHE in the formalin test was reversed by the systemic administration of the non-selective opioid antagonist, naloxone, the NO synthase inhibitor, Nω-nitro-arginine methyl ester (L-NAME) and the ATP-sensitive K+ channel inhibitor, glibenclamide. However, theophyline, a non-selective adenosine receptor antagonist did not reverse this effect. PHE, unlike morphine, did not induce tolerance to its anti-nociceptive effect in the formalin test after chronic administration and also morphine tolerance did not cross-generalize to PHE. Overall, the present results demonstrate that the anti-nociceptive effects of PHE might partially or wholly be due to the stimulation of peripheral opioid receptors through the activation of the nitric oxide-cyclic GMP-ATP-sensitive K+ (NO/cGMP/K+ATP)-channel pathway without tolerance induction after chronic administration.
  E. Woode , R.A. Poku , G.K. Ainooson , E. Boakye-Gyasi , W.K.M. Abotsi , T.L. Mensah and A.K. Amoh-Barimah
  The hydro alcoholic leaf extract of Ficus exasperata (Vahl) (family Moraceae) (FEE) was evaluated for its antinociceptive, anti-inflammatory and anti-pyretic properties in animal models. The leaf extract (10-300 mg kg-1) showed a dose-dependent anti-inflammatory activity in carrageenan-induced foot oedema in chicks, with an IC50 of 46.05±12.3 mg kg-1 which was approximately 3.5 times less potent than diclofenac (IC50:13.01±5.28 mg kg-1) and about 130 times less potent than dexamethasone (0.36±0.45 mg kg-1). In the formalin test, the extract showed dose dependent antinociceptive effects in both phases of the formalin test. The role of adenosinergic and opioidergic involvement in the antinociceptive effects was also investigated. While theophylline, a non-selective adenosine receptor antagonist, completely inhibited the antinociceptive effect of the extract, naloxone, an opioid antagonist had very little effect. The extract also showed weak activity in pyrexia induced by baker’s yeast. These results suggest antinociceptive as well as anti-inflammatory activities a confirmation of its traditional use. Also, the results show the involvement of adenosinergic pathway in the antinociceptive effects of FEE.
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