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by
G.I. Ndukwe |
Total Records (
2 ) for
G.I. Ndukwe |
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J.D. Habila
,
F.O. Shode
,
G.I. Ndukwe
,
J.O. Amupitan
and
A.J. Nok
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Background: Natural product compounds are the source of numerous chemotherapeutic agents. Investigations were carried out to evaluate the therapeutic properties of a C-3 modified oleanolic acid, 3β-acetoxyoleanolic acid (JH23), in the continue search for lead compounds. Results: The well-in-plate agar diffusion method used for the inhibition zone determination, showed that compound JH23 had a more enhanced activity as compared to JH16 (oleanolic acid) the parent nucleus, on most of the test organism; Candida guielemondi (JH23, 23±0.04; JH16, 22±0.03), Candida albicans (JH23, 29±0.05; JH16, 21±0.12), Candida krusei (JH23, 26±0.04; JH16, 23±0.001), Candida tropicalis (JH23, 30±0.02; JH16, 23±0.01), Trichophyton tonsurans (JH23, 29±0.03; JH16, 19±0.02) and Microsporum canis (30±0.01; JH16, 16±0.04). Conclusion: The results showed that functionality modification of organic compounds could lead to compounds with enhanced bioactivity. |
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O.J. Okunola
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A. Uzairu
,
G.I. Ndukwe
and
S.G. Adewusi
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To identify the concentrations of heavy metals in roadside environment , samples of roadside soils and vegetation were collected from 30 sites of 24 minor and major roads in Kaduna metropolis across two seasons. Subsequently, the concentrations of Cadmium (Cd) and Zinc (Zn) in the samples were analyzed using atomic absorption spectrophotometer. The mean concentration of Zn (mg kg-1 d.w.) in soil ranged from 45.37-237.96 and 24.21-123.14 for dry and wet season, respectively. While Cd mean concentration (mg kg-1 d.w.) in soil ranged from 1.96-6.80 and 0.38-2.44 for dry and season, respectively. Concentration of Zn in plant (mg kg-1) ranged from 27.78-185.19 and 15.43-138.89 for dry and wet season, respectively while concentration (mg kg-1 d.w.) of Cd ranged from 4.88-14.63 and 4.88-9.76 for dry and wet season, respectively. The Zn concentrations in both soil and plant leaves were found to be within ICRCL and FAO/WHO recommended limits, respectively. While Cd concentrations were found in excess of ICRCL and FAO/WHO recommended limits, respectively, this indicates potential health risk for human through the food chain. Comparative study showed that Cd and Zn values for soil and plant leaves were found high in the study area than the control area. This suggests that automobiles are a major source of these metals in roadside environment. |
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