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Articles by G.E. Eriyamremu
Total Records ( 7 ) for G.E. Eriyamremu
  G.E. Eriyamremu and O. Lolodi
  The growth pattern, chlorophyll content, lipid peroxidation as well as the activities of superoxide dismutase (SOD), Glutathione Peroxidases (GP) and catalase (CAT) were studied in the radicles, roots and shoots of Vigna unguiculata (the common beans) and Zea mays (maize) grown in soils contaminated with two nickel concentrations {0.1% (65 μM) and 0.2% (130 μM)}. Two hundred and seventy of either bean or maize seeds were germinated in these contaminated soils and 10 of each germinated plants were harvested after either the 7th, 14th and 21st days. The study observed chlorosis and stunted growth in the nickel-treated plants. Nickel accumulated in the tissues in increasing order of the radicle, root and the shoot. Treatment of the plants with 0.1% or 0.2% nickel did significantly (p<0.05) affected the activities of SOD, CAT and GP in the tissues studied throughout the experimental periods. Lipid peroxidation as measured by the production of malondialdehyde was significantly increased (p<0.05) in the plants grown on nickel-contaminated soils compared with the controls. These results indicate that nickel cause oxidative damage in Vigna unguiculata and Zea mays and as an adaptive feature, they increase the activities of antioxidant enzymes of the radicle, root and shoot.
  G.E. Eriyamremu , S.O. Asagba , V.E. Osagie , S.I. Ojeaburu and O. Lolodi
  This study reports the effect of unripe pawpaw and/or unripe plantain extracts on the phospholipid profile of the stomach and duodenum of normal rabbits. Supplementation of chow with unripe pawpaw or plantain extract significantly reduced (p<0.05) the weight gained by rabbits compared with the control. The total phospholipids content in the stomach and duodenum were significantly increased (p<0.05) in the test groups compared to the control. In the stomach and duodenum, phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SGM) were significantly increased (p<0.05) in the test groups compared to the control. Pawpaw occasioned a decrease in the PE/PC ratio in both tissues as against an increase observed in the SGM/PC ratio. The results presented suggests that unripe pawpaw meal and unripe plantain extract alter the phospholipid profile of the stomach and duodenum in ways which may affect membrane fluidity of these tissues and would have profound effect on the gastro-duodenal mucosa and thus have implication(s) for gastric and duodenal ulcers in rabbits.
  G.E. Eriyamremu , S.O. Asagba , S.O. Uanseoje , S.E. Omeregie and C.O. Omofoma
  The purpose of the present study was to evaluate the effect of Nigerian-Like Diet (NLD) and Western-Like Diets (WLD) on colonic mucosa lipid peroxidation, stress enzymes and nuclear membrane ATPase in the early stages of colon carcinogenesis in rats. Sixty male Wistar rats were grouped into three groups of 20 animals each; one group was fed with a Normal Diet (ND) and acted as the diet control. One group was fed with the NLD and the last group was fed with a WLD for 12 weeks. In each diet class, half of the animals were fed with the diet alone and the other half was fed with the diet containing cycas and after six weeks, a mid term study was carried out. Mid-term and full-term studies show a significant (p< 0.05) increase in nuclear ATPase activity of the rats fed with the WLD and a decrease in those fed the NLD compared with control. Feeding rats with the NLD significantly (p< 0.05) decreased the level of colonic mucosa lipid peroxidation compared with the WLD. A significant rise in the activity of Superoxide Dismutase (SOD) was observed in the rats fed the ND and NLD, while in the rats fed the WLD, SOD activity was compromised in both the mid- and full-term studies. The study shows that a NLD and WLD fed to rats alter mucosa plasma membrane lipid peroxidation, SOD and nuclear membrane ATPase in ways which suggest that the NLD may protect rats from colon carcinogenesis.
  G.E. Eriyamremu , V.E. Osagie , S.E. Omoregie and C.O. Omofoma
  this study the effect of sub-lethal levels of bonny light crude oil and its water soluble and insoluble fractions on stress enzymes was determined in tadpoles (Xenopus laevis) following two and four weeks exposure at different concentrations. Malondialdehyde (MDA) superoxide dismutase (SOD) and Glutathione Reductase (GR) were determined. It was observed that the treatment of tadpoles with whole crude or its fractions increased MDA. The head region contained a higher level SOD and GR compared with the tail region. We found that the Whole Crude (WC) had a less negative effect on lipid peroxidation and weight gain of tadpoles compared to the WSF. Presence of the WC, WSF or WIF was generally associated with increases in SOD and GR at lower concentration of exposure but decreases in the enzymes at higher doses of exposure was observed. However, longer exposure of tadpoles to WC or its fractions resulted in a negative effect on SOD and GR activities. Tadpole weights were negatively affected with WC and its fractions. The study shows that sub-lethal contaminations with WC, WSF or WIF induces membrane lipid peroxidation and reduce the ability of tadpoles to produce SOD and GR which may have metabolic costs.
  G.E. Eriyamremu , E.C. Onyeneke , N.J. Orhue , S.I. Ojeaburu , S.O. Uanseoje , V.E. Osagie and S.O. Asagba
  This study is aimed at assessing the role of the interaction between a Nigerian-Like Diet (NLD) or Western-Like Diet (WLD) and aspirin on energy metabolism and ATPases in early colon carcinogenesis. We observed that the WLD significantly (p< 0.05) increased intestinal length of rats compared with the NLD and interaction with aspirin slightly reversed this effect. The study also reports that the WLD increased the activities of some enzymes of energy metabolism compared with the NLD and that this increase is more than tripled with the inclusion of cycas in the diet. Aspirin administration reduced the activities of these enzymes more in the rats fed with the WLD than the NLD. We also observed that like the WLD, cycas inclusion in the diet of rats significantly raised the activity of Mg2+ ATPase (9% in the NLD and 34% in the WLD) and decreased Ca2+ ATPase (30% in the NLD to 42% in the WLD). Aspirin reversed these effects of cycas on these ATPases (37% in the NLD and 40% in the NLD for Ca2+ ATPase). This study demonstrates that an increase in Mg2+ ATPase and a decrease in Ca2+ ATPase is associated with early colon carcinogenesis and that while the WLD promotes these enzyme changes, the NLD have the opposite effect. The study also reveal that aspirin effect on the enzymes of energy metabolism and ATPases supports its protective role against colon carcinogenesis and that the effect of the drug is dependent on the protein content of the diet.
  S.O. Asagba , G.E. Eriyamremu , B.O. George and I. Okoro
  The present study highlights the potential of using lactate dehydrogenase (LDH, EC. 1.1.1.27) and aldehyde oxidase (AO, E.C.1.2.3.1.) activities and level of lipid peroxidation (LPO) in RBC as indices in monitoring the severity of P. falciparum malaria infections. Two hundred and forty one male patients from two major hospitals in Benin-City, Nigeria, with a history of malaria and confirmed to be infected with the P. falciparum malaria parasites by microscopic examination of Giemsa-stained thin blood slides were chosen for the study. These patients who fell within the 18-40 year age group were further grouped into low, moderate and high parasitemia based on the parasite density. A control group of healthy male adults in the same age range with the patients were also used for the study. Erythrocyte obtained from venous blood collected in heparinized tube after several centrifugations and appropriate washings with specified buffer solutions were assayed. The level of LPO in Infected Red Blood Cells (IRBC) was significantly higher (p<0.05) as compared to control with the level increasing with severity of malaria infection. Conversely, the LDH activity of IRBC was significantly (p<0.05) decreased relative to control and the decrease was also in the order of severity of the infection. However, no significant difference was observed in the AO activity in the different experimental groups. A significant (p<0.0001) negative correlation (r = - 0.9516) was observed between LDH activity and level of LPO. The results obtained suggest that LDH and LPO can be utilised as markers of malaria severity.
  O. Lolodi and G.E. Eriyamremu
  This study investigated the effect of a methanolic extract of Vernonia amygdalina (VA) on lipid peroxidation and antioxidant status of the colon of rats maintained on a normal diet containing 5% Cycas revoluta (cycads). Fifty male Wistar albino rats were randomly assigned into five groups of ten experimental animals in a study that lasted for six weeks. One control group was maintained on a normal diet only while another group was fed a normal diet containing 5% cycads. The other three groups were maintained on the normal diet and 5% cycads and orally fed 200 mg VA/kg body weight for 1, 5 or 6 weeks. The results obtained revealed that the level of malondialdehyde (an index of lipid peroxidation) was significantly elevated (p<0.05) in rats exposed to cycads only compared with the control. However, oral administration of VA in conjunction with exposure to cycads appeared to reduce the extent of lipid peroxidation to values that are not significantly (p>0.05) different from those of the control. The activity of Superoxide Dismutase (SOD) was significantly reduced (p<0.05) in the experimental animals fed cycads compared with the controls. Oral administration of VA seemed to counteract the effect of cycads on SOD in the colon as no significant difference (p>0.05) was observed in rats fed VA compared with the controls. The results of this study suggest that methanolic extract of VA may mitigate the biochemical consequences of cycasin-induced lipid peroxidation in the colon of rats.
 
 
 
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