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Articles by G.E. Egbung
Total Records ( 4 ) for G.E. Egbung
  M.U. Eteng , B.J. Bassey , I.J. Atangwho , G.E. Egbung , E.U. Eyong , P.E. Ebong and A.O. Abolaji
  Hypoglycemic and biochemical effects of herbal extracts of Vernonia amygdalina Del. (Compositae), Catharantus roseus (L.) G. Don (Apocynaceace) and chlorpropamide were compared and status of macrovascular complications evaluated using biochemical indices in normal and diabetic rats. The phytochemistry of the herbs was also assessed. Hypoglycemic activity of the herbs and chlorpropamide was evaluated on diabetic and non-diabetic rats but biochemical effects of the treatments was evaluated only on diabetic rats, assigned into four study groups (n = 8). Group I (control) received placebo (30% ethanol), treatment group II was gavaged with chlorpropamide in dose 14.28 mg kg-1 body weight, while groups III and IV were administered extracts of V. amygdalina (400 mg kg-1 body weight) and C. roseus (400 mg kg-1 body weight), respectively in 30% ethanol vehicle for 21 days. Results of the phytochemistry assessment identified alkaloids, cardiac glycosides, saponins, flavonoids, tannins in V. amygdalina and C. roseus. Triterpenes were identified only in V. amygdalina and anthroquinones only in C. roseus. All three treatments produced hypoglycaemic activity in normal and diabetic rats and significantly (p<0.05 to <0.01) reduced triglyceride and total Cholesterol relative to controls. C. roseus alone significantly (p<0.01) elevated HDL-Cholesterol. Serum protein significantly (p<0.05) increased in all treatments compared with controls. Urea levels decreased in all the treatments but more dramatic with chlorpropamide. Aminotransferase activity was not altered except serum ALT which was reduced in treated rats. Electrolyte profile showed dilutional hyponatremia with chlorpropamide treatment, which was absent in C. roseus treatment but mild in V. amygdalina. These changes in biochemical indices of toxicity and macrovascular complications are discussed with respect to the comparative therapeutic benefits of the three treatments.
  V.N. Osabor , G.E. Egbung and P.C. Okafor
  The nutritional value, mineral element compositions and phytochemical screening of Nypa fruiticans (mangrove swamps) were investigated. Proximate analyses of the husk showed that it contained moisture (65.14±.0.04% DM), fat (1.5±0.13% DM), crude protein (2.00±0.64% DM), fibre (2.47±0.09% DM), ash (4.20±0.14% DM), carbohydrate (24.63±0.17% DM) while the seeds contained moisture (41.96±0.28% DM), fat (0.94±0.01% DM), crude protein (1.27±0.01% DM), fibre (2.50±0.19% DM), ash (2.70±0.11% DM) and carbohydrate (51.0±1.71% DM). The moisture and carbohydrate contents revealed increased levels in both husk and seeds than other proximate parameters. The toxicant compositions of the husk revealed that hydro cyanide, oxalate and phytate contents were 0.63±0.02, 6.50±0.025 and 4.03±0.09 mg/100g DM respectively while the seeds revealed 0.08±0.01, 9.90±0.08 and 8.50±0.64mg/100g DM respectively. The hydro cyanide, oxalate and phytate contents were quite low in both seeds and husk. Mineral elements concentrations revealed potassium contents of 147.28±0.65mg/100g DM for the husk while the seeds showed 128.52±0.6mg/100g DM. The magnesium, sodium, iron, calcium, copper and zinc contents were virtually low in both seeds and husk of Nypa fruiticans. The vitamin A contents of the seeds and husk show that it contained 30.50±0.64 and 8.00±0.21mg/100g DM respectively.
  G.E. Egbung , E.U. Essien and I.J. Atangwho
  This study was carried out to investigate the effect of trans fatty acids on haematological indices. This was done by supplementing the diets fed to the albino Wistar rats with different concentrations of thermally oxidized palm oil and margarine as sources of trans fatty acids. Fifty albino Wistar rats were used for this study and were randomly selected into five groups of ten rats. Group 1 rats serving as the control received only the stock diet. Group 2 received 85% rat pellet supplemented with 15% margarine. Group 3 was fed with 75% rat pellet and 25% margarine. The fourth group was fed with 85% rat pellet supplemented with 15% thermally oxidized palm oil. Group 4 was fed with 75% rat pellet supplemented with 25% thermally oxidized palm oil. The feeding experiment lasted for six weeks at the end of which rats were sacrificed for determination of haematological indices. Results showed significant (p<0.05) decrease in Red Blood Cell (RBC) count, White Blood Cell (WBC) and platelet counts, Haemoglobin (Hb) concentration and Packed Cell Volume (PCV) in all test groups. This probably suggests that trans fatty acids may adversely affect the health of an individual and should be reduced in diet.
  V.N. Osabor , D.A. Ogar , P.C. Okafor and G.E. Egbung
  The African bread fruit is produced by Treculia, a wild tropical evergreen tree and has immense potential as a nutritional source for man. We evaluated its chemical and nutritional properties as a first step in realizing its food value. The seed [Dry Mass (DM) basis] contained 8% moisture, 12.5% crude protein, 4.2% fat 2.3% ash 1.6% fibre and 73% carbohydrate. The carbohydrate and protein contents in it were much higher than other parameters studied. Compositions of toxicants in seeds were quite low with levels (mg/100 g) of 0.06±0.12 for hydrocyanide 3.0±0.11 for oxalate and 0.76±0.01 for phytate. For mineral elements, the contents (mg/100 gDM) were 587±0.2 for potassium (K), 186±0.2 for Magnesium (Mg) and 850±0.02 for zinc (Zn). The sodium (Na), Calcium (Ca), iron (Fe) and Copper (Cu) contents were negligible. Results of phytochemical screening of the extract showed, that it contained appreciable amounts of flavonoid, polyphenols, anthraquinones, saponins and cardiac glycosides. These secondary metabolites are known to have microbial activity as well as other physiological activity.
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