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Articles by G.C. Akuodor
Total Records ( 3 ) for G.C. Akuodor
  G.C. Akuodor , C.C. Mbah , A.D. Essien , J.L. Akpan , B.C. Ezeokpo , T.C. Iwuanyanwu and U.A. Osunkwo
  Bridelia ferruginea which have some ethnomedicinal applications was investigated for ulcer-protective and anti-diarrhoeal effects. The ulcer-protective and anti-diarrhoeal activities of the aqueous stem bark extract were examined in rats and mice. Acute toxicity studies were also carried out. The extract exhibited ulcer-protective properties against ethanol and indomethacin induced ulceration activity in rats with maximal anti-ulcer activity observed at 400 mg kg-1. The extract dose dependently decreased intestinal propulsion of charcoal meal in mice. The aqueous extract of Bridelia ferruginea also exerted significant anti-enteropooling in mice. A significant antidiarrhoeal activity was also recorded in mice. The frequency of defaecation as well as the wetness of faecal droppings was reduced. In addition, the extract produced 100% inhibition of castor oil-induced diarrhoea in mice. The oral LD50 obtained was greater than 5000 mg kg-1 in mice. The results show that Bridelia ferruginea stem bark probably contains some active ingredients that potentially could be developed as useful drug for the treatment of ulcer and diarrhoea in Nigerian herbal traditional medicine.
  E.C.C. Udenze , V.B. Braide , C.N. Okwesilieze and G.C. Akuodor
  Objective: The pharmacological effects of Garcinia kola seed Powder (GKP) on blood sugar, lipid profile and atherogenic index of diabetic rats were studied. Materials and Methods: Thirty male albino Wistar rats were divided into six groups of five animals per group. The first two groups: non-diabetic control and non-diabetic treated were normal animals and orally given normal saline and 600 mg kg-1 b.wt. GKP respectively. The last four groups which were made diabetic using alloxan monohydrate had one diabetic untreated group, that received normal saline and three diabetic treated groups which received 300, 600 and 900 mg kg-1 b.wt. of GKP orally, respectively. At a single dose of treatment, blood was collected through tail vein puncture and blood glucose concentration measured with glucometer at 0, 2, 4, 6 and 8 h after which it was continued for 21 days. At the end of the treatment period, the animals were sacrificed and blood collected via cardiac puncture from where serum was recovered for lipid profile analysis. Results: GKP treatment significantly lowered blood glucose and improved lipid profile and atherogenic index of diabetic rats. This investigation therefore portrays GKP as an antidiabetic, antilipidemic and anti-atherogenic agent with a tremendous potential to protect against coronary heart disease.
  I. Obiajunwa-Otteh Juliet , G.C. Akuodor , I. Onyekpe Patricia and E.U. Umoh
  Background: An assessment of phytochemical composition and antimicrobial activity of the aqueous and methanol leaf extracts of Icacina senegalensis was carried out. Methodology: Phytochemical screening and antibacterial properties of both the aqueous and methanol leaf extracts of Icacina senegalensis were evaluated against clinical isolates of Staphlococcus aureus, Shigella spp., Salmonella typhi, Pseudomonas aeruginosa, Serratia marcescens and Escherichia coli using agar diffusion method. Results: Phytochemical screening revealed the presence of saponins, tannins, alkaloids, flavonoids, terpenoids, steroids and phenols. The aqueous and methanol leaf extracts exhibited good activity against the test organisms. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the leaf extract ranged from 2-60 μg mL-1. Conclusion: The findings indicate that both the aqueous and methanol leaf extracts of Icacina senegalensis contain bioactive components that have broad spectrum antibacterial properties.
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