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Articles by G. Hu
Total Records ( 3 ) for G. Hu
  Y Xu , G Yang and G. Hu
 

Interferon-induced transmembrane protein 1 (IFITM1) is an essential mediator of interferon--induced anti-proliferation. Here, we reported the interaction between IFITM1 and caveolin-1 (CAV-1), and their inhibitory regulatory function on extracellular signal-regulated kinase (ERK). The immunofluorescence staining result showed that IFITM1 localized in caveolae of the plasma membrane and could interact with CAV-1. Deletion mutagenesis clearly revealed that the hydrophobic transmembrane domains were responsible for the interaction between IFITM1 and CAV-1. It has been reported that CAV-1 has inhibitory effect on the phosphorylation of ERK, and subsequently ERK-mediated transcription. Our study showed the interaction of IFITM1- and CAV-1-enhanced CAV-1's inhibitory effect on ERK activation, whereas the IFITM1 did not activate ERK directly. This inhibitory effect was further confirmed by knocking down the endogenous CAV-1 using RNA interference. These results revealed that the interaction between IFITM1 and CAV-1 could enhance the inhibitory effect of CAV-1 on ERK activation.

  X. Du , B. Zhu , G. Hu , W. Mao , S. Wang , H. Zhang , F. Wang and Z. Shi
  Background Chronic low-grade inflammation is related to diabetes risk in population studies. Elevated levels of white blood cells (WBC) were related to the risk of diabetes in cross-sectional studies in the Chinese population. The objective of the study is to assess the prospective association between WBC and the risk of diabetes in the Chinese population. Methods We examined 7445 manual workers aged 18–59 years free from diabetes at baseline. Fasting glucose concentrations and white cell count were measured at annual health examinations from 1997 to 2007. Anthropometric measurements were taken by health workers. In the present study, each participant had at least two measurements of fasting blood glucose. Results During a mean of 4.94 years follow-up, 178 participants developed diabetes. After controlling for known risk factors for diabetes (age, gender, smoking, drinking, parental history of diabetes, body mass index, systolic blood pressure, hepatitis B surface antigen and liver function), a U-shaped association between WBC count and diabetes was found. The hazard ratios (HR) of diabetes across quartiles of WBC count were 1.87 (95% CI 1.15–3.05), 1.00, 1.46 (0.88–2.42) and 2.04 (1.28–3.25). The association was stronger among non-smokers: compared with the second quartile, the HR of diabetes for the first and fourth quartiles of WBC were 3.00 (1.28–7.03) and 3.16 (1.33–7.53). Adjusting for hepatitis B virus infection and liver function did not change the association.Conclusion Both low and high levels of WBC count were associated with an increased risk of diabetes in young workers.
  F. Zhang , L. Dong , C. P. Zhang , B. Li , J. Wen , W. Gao , S. Sun , F. Lv , H. Tian , J. Tuomilehto , L. Qi , C. L. Zhang , Z. Yu , X. Yang and G. Hu
  Aims  To investigate the trend in the prevalence of gestational diabetes mellitus during 1999-2008 in women living in urban Tianjin, China.

Methods  A universal screening for gestational diabetes mellitus has become an integral part of the antenatal care in Tianjin, China from 1998. A total of 105 473 pregnant women living in the six urban districts of Tianjin, China, participated in the gestational diabetes mellitus screening programme between December 1998 and December 2008. The screening test consisted of a 50-g 1-h glucose test. Women who had a glucose reading ≥ 7.8 mmol/l at the initial screening were invited to undergo the standard 2-h oral glucose tolerance test with a 75-g glucose load. Gestational diabetes mellitus was confirmed using the World Health Organization's diagnostic criteria.

Results  The adjusted prevalence of gestational diabetes mellitus increased by 2.8 times during 1999-2008, from 2.4 to 6.8% (P < 0.0001 for linear trend). In 2008, the age-specific prevalence of gestational diabetes mellitus was the highest among women aged 30-34 years (11.3%) and lowest among women aged 25 and under (1.2%). In women aged 35 years and more, the prevalence was 5.3%.

Conclusions  The prevalence of gestational diabetes mellitus has markedly been increasing in a universally screened urban Chinese female population and has become an important public health problem in China.

 
 
 
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