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Articles by G. Ara
Total Records ( 3 ) for G. Ara
  Y.H. Siddique , G. Ara , S. Jyoti and M. Afzal
  Parkinson’s Disease (PD) is characterized by the progressive loss of dopaminergic neurons. Drosophila mutants and transgenes have provided a platform to understand the mechanistic insight associated with the degenerative disease. In the present study, the effect of capsaicin was studied on the climbing ability of the PD model Drosophila expressing normal human alpha synuclein (h-αS) in the neurons. These flies exhibit locomotor dysfunction as the age progresses. Capsaicin at final concentration of 0.1, 0.5, 0.75 and 1.0 μL mL-1 was supplemented with the diet and the flies were allowed to feed for the 21 days. Capsaicin showed a dose dependent significant (p<0.05) delay in the loss of climbing ability of PD model flies as compared to the untreated PD flies. The results suggest that the capsaicin is potent in delaying the climbing disability of PD model flies and also supports the utility of this model in studying PD symptoms.
  J. Gupta , Y.H. Siddique , T. Beg , G. Ara and M. Afzal
  The aim of this review is to focus some light on the beneficial effects of the tea polyphenols on human health, based on various laboratory, epidemiological and clinical studies carried out on tea and tea polyphenols in the last few years. Tea is second only to water as the most consumed beverage in the world. Tea has been consumed worldwide since ancient times to maintain and improve health. The health benefits associated with tea consumption have resulted in the wide inclusion of green tea extracts in botanical dietary supplements, which are widely consumed as adjuvants for complementary and alternative medicines. Depending upon the level of fermentation, tea can be categorized into three types: green (unfermented), oolong (partially fermented) and black (highly to fully fermented). Black tea represents approximately 78% of total consumed tea in the world, whereas green tea accounts for approximately 20% of tea consumed. Tea is particularly rich in polyphenols, including catechins, theaflavins and thearubigins, which are thought to contribute to the health benefits of tea. Tea polyphenols comprise about one-third of the weight of the dried leaf and they exhibit biochemical and pharmacological activities including antioxidant activities, inhibition of cell proliferation, induction of apoptosis, cell cycle arrest and modulation of carcinogen metabolism. Several studies demonstrate that most tea polyphenols exert their effects by scavenging Reactive Oxygen Species (ROS) since excessive production of ROS has been implicated in the development of a variety of ailments including cancer of the prostate gland (CaP). Tea catechins include (-)-epicatechin (EC),(-)-epigallocatechin (EGC), (-)-epicatechin gallate (ECG) and (-)-epigallocatechin gallate (EGCG). These catechins have been shown to be epimerized to (-)-catechin (C), (-)-gallocatechin (GC), (-)-catechin gallate (CG) and (-)-gallocatechin gallate (GCG), respectively, during heat treatment. Tea polyphenols act as antioxidants in vitro by scavenging reactive oxygen and nitrogen species and chelating redox-active transition metal ions. Among the health-promoting effects of tea and tea polyphenols, the cancer-chemopreventive effects in various animal model systems have been intensively investigated; meanwhile, the hypolipidemic and antiobesity effects in animals and humans have also become a hot issue for molecular nutrition and food research. In vitro and animal studies provide strong evidence that tea polyphenols may possess the bioactivity to affect the pathogenesis of several chronic diseases, especially cardiovascular disease and cancer. Research conducted in recent years reveals that both black and green tea have very similar beneficial attributes in lowering the risk of many human diseases, including several types of cancer and heart diseases.
  M. Afzal , Y.H. Siddique , G. Ara , T. Beg and J. Gupta
  Mental retardation has been the traditional foothold of psychologists and psychometricians, apart from clinicians and biologists. Nearly 30,000 genes control neurogenetic disorders. While these genes are yet to be explored, their ultimate expression and regulation defies a mechanistic model of behavioural and intellectual deficiency. Mental retardation, therefore, will be a complex problem to be diagnosed and cured. A polygenic theory demands delineating Quantitative Trait Locus (QTL) problem, yet to be formulated among humans. At the molecular level, molecular genetics of neurological disorders have been worked out. Taking from basic roots of neuronal functioning and their integration at various levels of the central nervous system, the mutations of neuronal channelopathies resulting into loss of brain function (seizures, convulsions, epilepsy), uncontrolled muscle movement (ataxia), headache with vomiting and nausea (migraine) have been worked out. The trinucleotide disorders in huntington and mutations in the prion protein causing various types of encephalopathies have been established. Present study touches upon some important areas of mental retardation and psychiatry through history, cutting across diverse disciplines and methodologies and attempts recent developments in the field.
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