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Articles by G. R. M. Astaq Mohal Khan
Total Records ( 4 ) for G. R. M. Astaq Mohal Khan
  Atiqur Rahaman , Abu Sayeed , Anwarul Islam , Dulaly Chowdhury , Golam Sadik and G. R. M. Astaq Mohal Khan
  A triterpenoid, Bet-20(29)-en-3-ol-28-oic acid (1) was isolated from the ethyl acetate extract of Nymphoides cristatum (Roxb.) O.kuntze and its structure was elucidated on the basis of spectral evidences. This is the first report of isolation of this compound from this plant. The compound was screened for antimicrobial activity against a number of pathogenic bacteria and fungi and the cytotoxic activity by brine shrimp lethality bioassay. The test agent exhibited significant antimicrobial activity against most of the bacteria and fungi. The minimum inhibitory concentration (MIC) of the test agent determined against Bacillus cereus, Bacillus subtilis, Escherichia coli and Shigella sonnei was found to be 64, 128, 64 and 32 μg/ml respectively. The compound also showed prominent cytotoxic activity. The LC50 (median lethal concentration) was 15.39 μg/ml. 50.
  Anwarul Islam , Abu Sayeed , Md. Anwar-Ul Islam , G. R. M. Astaq Mohal Khan , M. Helal U. Biswas and M. Shah Alam Bhuiyan
  The research work was conducted to investigate the antimicrobial and cytotoxic evaluation of a flavonone. The flavonone, 5-methoxy-7-hydroxy flavonone (1), has been isolated from the leaves extract of Zanthoxylum budrunga and its structure was established on the basis of structural evidence. This is the first report of its occurrence from the plant. The compound (1) showed significant antimicrobial activity against a number of pathogenic bacteria and fungi. The minimum inhibitory concentration (MIC) of the compound (1) was found to be 16μg ml‾1 against Staphylococcus aureus. The compound showed prominent cytotoxic activity the LC50 and LC90 values of the compound (1) were found to be 16.24 and 56.56μg ml‾1, respectively.
  Farque Ahmed , Abu Sayeed , Anwarul Islam , S. M. Abdus Salam , Golam Sadik and G. R. M. Astaq Mohal Khan
  The ethyl acetate (C2H5COOCH3) extract of the roots of Vanda roxburghii Br. is known to have a significant antimicrobial activity. The investigation was carried out on the C2H5COOCH3 extract for the isolation and characterization of the active principle (s). The extract afforded a glycoside, 17-β-hydroxy-14, 20-epoxy-1-oxo- [22R]-3β-[O-β-D-glucopyranosyl]-5,24-withadienolide (VR-2), the structure of which was elucidated on the basis of spectral evidences. Compound VR-2 was screened against a wide variety of pathogenic bacteria and fungus for its antimicrobial activity by disc diffusion method. The compound showed significant antibacterial activity against most of the tested strain of bacteria and produced zone of inhibition between 14 to 28mm. The compound also showed significant antifungal activity and the minimum inhibitory concentration (MIC) of VR-2 against Bacillus cereus, Bacillus subtilis, Escherichia coli, Shigella dysenteriae and pseudomonus aeruginosa was determined and the values were 8, 32, 16, 8 and 16μg ml-1, respectively.
  Anwarul Islam , Abu Sayeed , Golam Sadik , M. Motiur Rahman and G. R. M. Astaq Mohal Khan
  Two clerodane diterpines viz., Kolavenic acid (1) and 16-oxo-cleroda-3, 13(14) E-diene-15-oic acid (2) were isolated from the petroleum ether (C2H5-O-C2H5) extract of the seed of Polyalthia longifolia and were screened against fourteen pathogenic bacteria for their antibacterial activities. The test materials exhibited strong activities against most of the test bacteria. The minimum inhibitory concentration (MIC) of the compound (1) and (2) was determined against Bacillus cereus, Bacillus subtilis, Escherichia coli, Shigella flexneriae and Shigella boydii which were 64, 64, 32, 16 and 32μg ml-1 for compound (1) and 16, 32, 8, 4 and 16 μg ml-1 for compound (2), respectively. The cytotoxic activity of the compound (1) and (2) was determined by brine shrimp lethality bioassay. Both the compounds showed significant cytotoxic activities and LC50 values of Kolavenic acid (1) and 16-oxo-cleroda-3, 13(14)E-diene-15-oic acid (2) were 3.16 and 2.52μg ml-1, respectively.
 
 
 
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