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Articles by G Shi
Total Records ( 1 ) for G Shi
  R. S Misra , G Shi , M. E Moreno Garcia , A Thankappan , M Tighe , B Mousseau , K Kusser , S Becker Herman , K. L Hudkins , R Dunn , M. R Kehry , T. S Migone , A Marshak Rothstein , M Simon , T. D Randall , C. E Alpers , D Liggitt , D. J Rawlings and F. E. Lund
 

Survival of mature B cells is regulated by B cell receptor and BAFFR-dependent signals. We show that B cells from mice lacking the Gq subunit of trimeric G proteins (Gnaq–/– mice) have an intrinsic survival advantage over normal B cells, even in the absence of BAFF. Gnaq–/– B cells develop normally in the bone marrow but inappropriately survive peripheral tolerance checkpoints, leading to the accumulation of transitional, marginal zone, and follicular B cells, many of which are autoreactive. Gnaq–/– chimeric mice rapidly develop arthritis as well as other manifestations of systemic autoimmune disease. Importantly, we demonstrate that the development of the autoreactive B cell compartment is the result of an intrinsic defect in Gnaq–/– B cells, resulting in the aberrant activation of the prosurvival factor Akt. Together, these data show for the first time that signaling through trimeric G proteins is critically important for maintaining control of peripheral B cell tolerance induction and repressing autoimmunity.

 
 
 
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