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Articles by Fulya Benzer
Total Records ( 2 ) for Fulya Benzer
  Mine Erisir , Ebru Beytut , Fatih Mehmet Kandemir and Fulya Benzer
  The effects of dietary intake of vitamin E and selenium on aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities in rats treated with high doses of prednisolone were investigated. Rats were divided into 5 groups. Groups 3, 4 and 5 received a daily supplement in their drinking water of 20 mg vitamin E, 0.3 mg Se and a combination of vitamin E and Se, respectively, for 30 days. For 3 days subsequently, the control group (group 1) was given a placebo and the remaining 4 groups were injected intramuscularly with 100 mg kg-1 body weight prednisolone. After the last administration of prednisolone, 10 rats from each group were killed at 4, 8, 12, 24 and 48 h and the activities of aspartate aminotransferase and alanine aminotransferase enzymes in their tissues were measured. In the group, treated with prednisolone alone, AST activity in the liver was not affected, the ALT activity was significantly decreased at 12 h only. AST and ALT activities in the kidneys were significantly decreased by prednisolone at all time periods. AST activity in the heart also decreased in the prednisolone group between 4 and 24 h, significantly at 12 h. Significant decreases were found at 4, 8 and 12 h in the heart ALT activity of the prednisolone administered group. AST activity in the liver, kidneys and heart was lower in vitamin E and Se supplemented groups than control and prednisolone groups. In the combination group, compared to both the control and prednisolone groups, AST activity in the kidneys and heart was decreased, but increased in liver. Vitamin E and Se alone or in combination had a preventive effect on the decrease of ALT activity in the liver and kidneys caused by prednisolone. ALT activity in the heart tissue of the vitamin E supplemented group was found to be increased at all time periods, however, it reduced in the Se and combination groups compared to the prednisolone group. Therefore, the present study demonstrates that vitamin E and Se alone or in combination may prevent the decrease in ALT activity in the liver and kidneys caused by high doses of prednisolone.
  Fulya Benzer and Seval Yilmaz
  This experiment was conducted to evaluate the effects of Ornithobacterium rhinotracheale (ORT) infection on oxidative stress and the activity of antioxidant enzymes in blood, trachea and lung tissues of broilers. Broiler chickens were divided into 2 groups, each consisting of 30 animals. Group 1 was used as control group; Group 2 was used as infection group. The 2nd group was infected by aerosol route with 1 mL of a pure culture of ORT strain B3263/91 (serotype A) containing 3.8x108 CFU mL-1. At the end of the experiment blood and tissue samples were collected and biochemical parameters were determined. While, plasma Malondialdehyde (MDA) and Nitric Oxide (NO) levels were increasing at infection group than control group, erythrocyte Catalase (CAT) and Glutathione Peroxidase (GSH-Px) activities were decreasing in accordance with control group. Levels of MDA and NO in trachea tissue increased at infection group more than control group; but activities of CAT and GSH-Px did not change. MDA level and CAT activity increased in lung tissue, however level of NO decreased more than the control group. GSH-Px activity had no change statistically. There are alterations in wide array of oxidants and antioxidants, with balance shifting toward increased oxidative stress in ORT infection. Therapeutic augmentation of the antioxidant defenses might be beneficial.
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