Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
 
Articles by Fuat DILMEC
Total Records ( 2 ) for Fuat DILMEC
  Abdullah OZGONUL , Nurten AKSOY , Fuat DILMEC , Ali UZUNKOY and Şahin AKSOY
 

Aim: The aim of this study was to compare the antioxidative status in patients with colorectal cancer and healthy controls, based on measurements made using a novel method.

Materials and Methods: The study was conducted between 2005 and 2007, and included 30 patients with colorectal cancer and 30 healthy controls. To determine the antioxidative status of the patients and healthy controls, serum total antioxidant capacity was measured using a novel automated method. Blood samples were taken from the healthy controls and the patients.

Results: Total serum antioxidant capacity was significantly lower in colorectal cancer patients than in healthy persons (P < 0.023).

Conclusions: Patients with colorectal cancer are exposed to oxidative stress, which may have a role in the pathogenesis of the disease. The novel automated method used in this study was developed in our laboratory, and is feasible and fully automated; therefore, it may be useful for evaluating oxidative-antioxidative balance in patients with colorectal cancer.

  Abdussemet HAZAR , Fuat DILMEC , Mustafa GOZ , Aydemir KOCARSLAN , Mehmet Salih AYDIN and Abbas Heval DEMIRKOL
  Aim: To investigate the association between the paraoxonase 1 (PON1) c.163T>A and c.575A>G polymorphisms and coronary artery disease (CAD), and whether specific polymorphisms in the PON1 gene are associated with CAD in the southeastern Turkish population. Many different genetic and clinical factors have been identified as causes or contributors to atherosclerosis. Complex diseases such as CAD, hypertension, and diabetes are usually caused by an individual’s susceptibility to various genes, environmental factors, and the interactions between them. The PON1 enzyme has been implicated in the pathogenesis of atherosclerosis and CAD. Materials and methods: Enrolled in this study were 61 patients with CAD and 103 healthy individuals; their DNA was isolated. A polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to determine the frequencies of the PON1 gene (NM_000446.5, GI: 5444) c.163T>A (Hsp92IIT>A) and c.575A>G (AlwIA>G) polymorphisms in CAD cases. Results: Our data indicated that the body mass index (BMI) (27.5 ± 5.7), low-density lipoprotein (LDL-C) values (127.0 ± 45.8), and frequencies of diabetes (13.0) and hypertension (35.0) were significantly higher in CAD patients than in the control subjects (25.9 ± 4.1; 105.6 ± 26.3; 2.0; and 19.0, respectively) (P < 0.05). No significant differences were observed in the frequencies of the c.163T>A and c.575A>G genotypes of the PON1 gene in CAD patients compared to healthy individuals (P > 0.05). Conclusion: The PON1 gene c.163T>A and c.575A>G polymorphisms did not represent an important risk factor for this disease in the southeastern Turkish population.
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility