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Articles by Francesco Menichini
Total Records ( 3 ) for Francesco Menichini
  Daniela Rigano , Filomena Conforti , Carmen Formisano , Francesco Menichini and Felice Senatore
  Different Iris species are known as medicinal plants. The aim of this study was to evaluate the in vitro antioxidant and cytotoxic activities of different extracts from Iris pseudopumila Tineo flowers and rhizomes. The radical scavenging activity was assessed by means of DPPH assay. The antioxidant activity was assessed by means of two tests: bleaching of β-carotene and lipid peroxidation of liposomes. Methanolic and chloroform extracts from the flowers of I. pseudopumila showed a significant antiradical effect with IC50 of 101 and 83 μg mL-1, respectively. As regards to lipid peroxidation, the best activity was showed by methanolic extract of flowers (IC50 of 18 μg mL-1) and chloroformic extract of rhizomes (IC50 33 μg mL-1). The cytotoxic activity was carried out using the SRB assay. The chloroform extract from rhizomes demonstrated a good cytotoxic activity against amelanotic melanoma cancer cell line (C32) with an IC50 of 57 μg mL-1. The results obtained support the ethnomedical claims for the plant.
  Rosa Tundis , Monica R. Loizzo , Marco Bonesi , Federica Menichini , Daniela Dodaro , Nicodemo G. Passalacqua , Giancarlo Statti and Francesco Menichini
  This study is aimed to evaluate the in vitro cytotoxicity of Senecio stabianus Lacaita (Asteraceae) against renal adenocarcinoma ACHN, hormone-dependent prostate carcinoma LNCaP, amelanotic melanoma C32 and human breast adenocarcinoma MCF-7 cell lines. The n-hexane extract showed an interesting activity with IC50 values of 62.7 and 71.1 μg mL-1 against C32 and LNCaP, respectively. Two compounds identified in the n-hexane extract, linalool and β-caryophyllene, were found to be active against C32 cells (IC50 values of 23.2 and 20.1 μg mL-1, respectively). Among tested constituents, the highest activity was found when α-humulene was applied to LNCaP cells (IC50 of 11.2 μg mL-1). In order to complete the phytochemical study on S. stabianus, which has not been investigated previously, the most characteristic secondary metabolites of Senecio genus, pyrrolizidine alkaloids (PAs), were analysed. Here we report the isolation, structural elucidation and identification of nine PAs.
  Filomena Conforti , Monica Rosa Loizzo , Mariangela Marrelli , Federica Menichini , Giancarlo A. Statti , Dimitar Uzunov and Francesco Menichini
  In the present work the qualitative and quantitative analysis of Amaryllidaceae-type alkaloids in the aerial parts and bulbs of Galanthus reginae-olgae Orph. subsp. vernalis Kamari is presented for the first time using GC-MS analysis. The alkaloids galanthamine, lycorine, and tazettine were identified in both extracts while crinine and neronine were found only in the bulbs. The yield of alkaloid fraction from bulbs (36.8%) is very high compared to the yield from aerial parts (9.34%). Lycorine was the major component in both fractions. The antioxidant potential was determined by three complementary methods. The preparations to reduce the stable free radical DPPH to the yellow-colored 1,1-diphenyl-2-picrylhydrazyl with IC50 values of 39 and 29 μg/mL for MeOH extracts from aerial parts and bulbs, respectively. The higher activity was given by EtOAc fraction of aerial parts with IC50 of 10 μg/mL. This activity is probably due to the presence in EtOAc fraction of polar compounds such as polyphenols. The fraction exhibited a significant antioxidant capacity also in the β-carotene-linoleic acid test system.A higher level of antioxidant activity was observed for EtOAc fraction from bulbs with IC50 of 10 μg/mL after 30 min and 9 μg/mL after 60 min of incubation. In contrast, the fraction from bulbs performed poorly in the lipid peroxidation liposomes assay. Significant activity was obtained for dichloromethane fraction from aerial parts (IC50 of 74 μg/mL). The major abundance of alkaloid in dichloromethane fraction may be responsible of the bulbs anti-cholinesterase highest activity (38.5%) at 0.5 mg/mL.
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