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Articles by Filomena Conforti
Total Records ( 3 ) for Filomena Conforti
  Daniela Rigano , Filomena Conforti , Carmen Formisano , Francesco Menichini and Felice Senatore
  Different Iris species are known as medicinal plants. The aim of this study was to evaluate the in vitro antioxidant and cytotoxic activities of different extracts from Iris pseudopumila Tineo flowers and rhizomes. The radical scavenging activity was assessed by means of DPPH assay. The antioxidant activity was assessed by means of two tests: bleaching of β-carotene and lipid peroxidation of liposomes. Methanolic and chloroform extracts from the flowers of I. pseudopumila showed a significant antiradical effect with IC50 of 101 and 83 μg mL-1, respectively. As regards to lipid peroxidation, the best activity was showed by methanolic extract of flowers (IC50 of 18 μg mL-1) and chloroformic extract of rhizomes (IC50 33 μg mL-1). The cytotoxic activity was carried out using the SRB assay. The chloroform extract from rhizomes demonstrated a good cytotoxic activity against amelanotic melanoma cancer cell line (C32) with an IC50 of 57 μg mL-1. The results obtained support the ethnomedical claims for the plant.
  Filomena Conforti , Mariangela Marrelli , Giancarlo Statti , Federica Menichini , Dimitar Uzunov , Umberto Solimene and Francesco Menichini
  The two studied Calamintha species showed different polyphenolic content and sterol composition. Calamintha grandiflora possessed twice the polyphenolic content of Calamintha nepeta subsp. glandulosa, while the latter contained a higher number of sterols. Among them, stigmast-5-en-3β-ol was found to be the major constituent. The methanolic extract of C. grandiflora was more potent than the C. nepeta subsp. glandulosa methanolic extract in a DPPH assay, while the activity of the C. grandiflora EtOAc fraction was weaker than its C. nepeta subsp. glandulosa counterpart. Fractions of C. nepeta subsp. glandulosa showed higher activity using a β-carotene bleaching test. The petrol ether fraction of C. grandiflora showed significant inhibition of NO production.
  Filomena Conforti , Monica Rosa Loizzo , Mariangela Marrelli , Federica Menichini , Giancarlo A. Statti , Dimitar Uzunov and Francesco Menichini
  In the present work the qualitative and quantitative analysis of Amaryllidaceae-type alkaloids in the aerial parts and bulbs of Galanthus reginae-olgae Orph. subsp. vernalis Kamari is presented for the first time using GC-MS analysis. The alkaloids galanthamine, lycorine, and tazettine were identified in both extracts while crinine and neronine were found only in the bulbs. The yield of alkaloid fraction from bulbs (36.8%) is very high compared to the yield from aerial parts (9.34%). Lycorine was the major component in both fractions. The antioxidant potential was determined by three complementary methods. The preparations to reduce the stable free radical DPPH to the yellow-colored 1,1-diphenyl-2-picrylhydrazyl with IC50 values of 39 and 29 μg/mL for MeOH extracts from aerial parts and bulbs, respectively. The higher activity was given by EtOAc fraction of aerial parts with IC50 of 10 μg/mL. This activity is probably due to the presence in EtOAc fraction of polar compounds such as polyphenols. The fraction exhibited a significant antioxidant capacity also in the β-carotene-linoleic acid test system.A higher level of antioxidant activity was observed for EtOAc fraction from bulbs with IC50 of 10 μg/mL after 30 min and 9 μg/mL after 60 min of incubation. In contrast, the fraction from bulbs performed poorly in the lipid peroxidation liposomes assay. Significant activity was obtained for dichloromethane fraction from aerial parts (IC50 of 74 μg/mL). The major abundance of alkaloid in dichloromethane fraction may be responsible of the bulbs anti-cholinesterase highest activity (38.5%) at 0.5 mg/mL.
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