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by
Figen Narin |
Total Records (
2 ) for
Figen Narin |
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Figen Narin
,
Nazmi Narin
,
Fatmagul Basarslan
,
Ali Baykan
,
Sadettin Sezer
,
Hulya Akgun
,
Aynur Akin
,
Mustafa Akcakus
and
Hakan Ceyran
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Aim: To evaluate the protective effect of tryptophan on an experimentally
produced hypoxic myocardial injury via biochemical and pathological parameters.
Materials and methods: A total of 26 rabbits were divided into 3 groups. Group
1 (n = 9) was only exposed to hypoxia. Group 2 (n = 10) was exposed to hypoxia
and received L-tryptophan (200 mg/kg per day, orally for 5 days). Group 3 (n =
7) was the control group. Before the hypoxic injury and after the delivery of
the medication, serum samples were taken for troponin-I, creatine kinase myocardial
isoenzymes (CK-MB), lactate dehydrogenase (LDH), glutathione peroxidase (GSH-Px),
superoxide dismutase (SOD), malondialdehyde (MDA), and nitric oxide (NO) analysis,
and then the rabbits were sacrificed. Next, the myocardium samples were taken
and the myocardial NO, MDA, SOD, and GSH-Px enzyme activity levels were studied
histopathologically.
Results: In group 1, Serum GSH-Px and SOD activities were decreased. Conversely,
troponin-I, CK-MB, and LDH were elevated. Severe cardiac injury was observed histopathologically.
In group 2, serum troponin-I and SOD values were increased. Mild cardiac injury
was demonstrated histopathologically. When groups 1 and 2 were compared, tissue
NO and MDA levels in group 1 were higher compared to group 2, but GSH-Px level
was found decreased in group 1.
Conclusion: Our findings support that there is a clear effect of the free
oxygen radicals and the lipid peroxidation products on hypoxic cardiac injury.
In addition, L-tryptophan supplementation has a strong protective effect on hypoxic
heart by antioxidant activity. |
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Figen NARIN
,
Abdulhakim COSKUN
,
Nazmi NARIN
,
Ali BAYKAN
,
Sertac Hanedan ONAN
,
Abdulkerim COSKUN
,
Muammer Hakan POYRAZOGLU
and
Rusen EREZ
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Aim: Hyperhomocysteinemia was induced in rabbits using methionine. Ocular blood flow changes were examined by color Doppler ultrasonography (CDU).
Materials and methods: Fifty New Zealand rabbits were divided into 5 groups. Groups 1-4 received one of the following chemicals: methionine only, methionine plus vitamin B6, methionine plus vitamin B12, or methionine plus folic acid. Controls received no chemicals. Serum homocysteine levels were measured on treatment days 1 and 60. Orbital vessels were examined by CDU on day 60.
Results: In the 4 study groups, homocysteine levels were significantly elevated on day 60 compared to the levels on day 1 (P < 0.05). Elevations of homocysteine levels in group 1 were greater than those of groups 2 and 4 on day 60 (P < 0.05). When results of ocular blood flow changes were compared, no statistically significant difference was found based on flow velocities in the ophthalmic artery. Measurements from the ciliary artery revealed a statistically significant decrease in flow velocity in the study groups (P < 0.05).
Conclusion: Using CDU, we found that flow velocities in the ciliary artery were decreased. This condition is attributed to atherosclerotic and thromboembolic alterations of the ocular vessels due to hyperhomocysteinemia. |
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