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Articles by Fenghua Liu
Total Records ( 2 ) for Fenghua Liu
  Anru Wang , Fenghua Liu , Zhepeng Wang , Xue Jiang , Wei Wang , Kedao Teng and Jianqin Xu
  The purpose of this study was to establish a model of avian viral disease for antiviral drug discovery and development. A Chinese IBDV strain BC6/85 was inoculated into 5-week-old specific-pathogen-free (SPF) male White Leghorn chicken and the clinicopathologic features of disease were compared with those reported before. Birds were monitored clinically and euthanized sequentially with collection of tissues. Tissues were examined by histopathology to observe microscopic lesions, by immunohistochemistry to detect viral protein, by electron microscope to observe ultrastructural changes of the plical epithelium of the bursa of Fabricius and by flow cytometry to detect apoptosis in bursal lymphocytes. Comparing of mean body weight gains and bursal weight indices between control group and virus inoculated groups, significant decreases are displayed. It was observed that the young chickens infected developed the typical histopathological changes of disease. The bursa of Fabricius revealed lesions characteristic of infectious bursal disease and virus particles identical to IBDV were found in the necrotic cells of the follicles. The mucosal surface of the bursal plica was erosion, ulceration and became smooth in the infected chicken groups. And the apoptotic cells were increased after 2 days of the virus inoculation. Morphologically, we clearly demonstrated that replication of IBDV in the bursa during the acute phase of infection and provided new information on the pathogenesis of IBDV.
  Yaocheng Chu , Ruiling Qin , Xinguo Li , Fenghua Liu , Jianqin Xu , Fenghua Liu and Jianqing Xu
  Qingliang electuary plays important roles in speeding up heat dissipation, enhancing blood circulation and improving the bodys immune system. The main ingredients of a qingliang electuary are Gypsum fibrosum (GF) and Rhizoma atractylodis (RA). Here, researchers report the effect of these two ingredients on in vitro proliferation of mouse splenic lymphocyte. The extracts of GF and RA along with ConA were tested under high temperatures (37, 39 and 42C) in combination with different incubation times (1 or 4 h) using the MTT (3-(4, 5)-dimethylthiahiazo (-z-y1)-3, 5-di-phenytetrazoliumromide) Method. The results showed that ConA significantly stimulated lymphocyte proliferation at 37C. Under 39 and 42C, the stimulation diminished as incubation time prolonged. High dose GF (500 μg mL-1) significantly inhibited proliferation under all tested conditions but low dose GF (0.05 μg mL-1) significantly increased lymphocyte proliferation at 42C after 1 h incubation. RA water extract at 500 μg mL-1 significantly increased lymphocyte proliferation under all tested conditions. The effect of RA oil was weaker compared to RA water extract and not consistent under different incubation conditions.
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