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Articles by Feng-Yang Chen
Total Records ( 4 ) for Feng-Yang Chen
  Li-Fei Zhou , Fu-Gen He , Bai-Zhen Lu and Feng-Yang Chen
  Shaoyao Ruangan Heji (SYRG), a liquid pharmaceutical formulation of traditional Chinese medicine, has been used clinically for the prevention and treatment of chemotherapy-induced liver injury in Zhejiang Cancer Hospital (China) for 37 years. However, its underlying therapeutic mechanism is still unclear. Because oxidative stress is a crucial etiological factor implicated in the pathology of chemotherapy-induced liver injury, in this study, the protective effect of SYRG on carbon tetrachloride (CCl4)-induced oxidative stress and liver injury in mice were evaluated and its mechanisms were investigated by Mouse Stress and Toxicity Pathway Finder PCR Array. The results showed that pretreatment with SYRG significantly attenuated CCl4-induced liver damage in mice, evidenced by decreased serum enzyme activities of ALT and AST, which was also supported by the histopathological examination of the mice liver. The SYRG also showed a significant protective effect against CCl4-induced hepatic MDA elevation and depletion of T-AOC, SOD and GSH content. Furthermore, SYRG regulated 25 genes related to six stress and toxicity pathways (Oxidative stress, hypoxia, cell necrosis, inflammatory response, DNA damage signaling and heat shock proteins/unfolded protein response) in the impaired liver induced by CCl4. These results indicated that SYRG has protective effects against CCl4-induced liver injury and its underlying mechanisms involve the modulation of multiple stress and toxicity pathways. These findings would be beneficial for understanding of the therapeutic effects of SYRG in treatment of chemotherapy-induced liver injure in clinic.
  Feng-yang Chen , Tian-li Teng , Qin Li , Shi-fang Xu , Qun Chen , Xiao-yu Li and Yi-ping Ye
  Background and Objective: The prevalence of Ulcerative Colitis (UC) in most countries has increased and it is necessary to develop new therapeutic options for UC. Siegesbeckia pubescens is a traditional Chinese medicine widely used for the treatment of inflammatory and autoimmune diseases in clinic. The purpose of this study is to evaluate its therapeutic effect against UC. Materials and Methods: Experimental UC in rats was induced by iodoacetamide (IA) through instilling into the lumen of the colon. The aqueous extract of S. pubescens (SPA) was orally administered 3 days before IA instillation and continued upto 4 days. Throughout the experiment, rats were monitored for body weight loss, stool consistency and fecal occult blood which were quantified as Disease Activity Index (DAI). At the end of the experiment, rats were sacrificed and colonic length, weight, macroscopic and histopathological damage were examined. Furthermore, the mRNA expression levels of pro-inflammatory cytokines (TNF-α, IL-6 and IL-1β) were analyzed in the colonic tissues by real-time PCR. The data were examined for their statistical significance of difference with ANOVA and the standard’s t-test. Results: The results showed that SPA significantly ameliorated typical symptoms of IA-induced rat colitis including weight loss, mucus stool and bloody diarrhea. Moreover, macroscopic and histopathologic scoring showed that SPA suppressed IA-induced colonic edema, hyperemia, necrotic destruction of epithelium and inflammatory cellular infiltration. In addition, SPA inhibited IA-induced pro-inflammatory cytokines (TNF-α, IL-6 and IL-1β) mRNA expression in colon. Conclusion: These evidences indicated that SPA has therapeutic effects against IA-induced colitis in rats which suggested the potential of S. pubescens as an agent for use in the treatment of UC for the first time.
  Feng-Yang Chen , Li-Fei Zhou , Xiao-Yu Li , Shi-Fang Xu , Li-Juan Gao , Hong-Xiang Sun and Yi-Ping Ye
  Background and Objective: Stephanthraniline A (STA), a natural C21 steroid isolated from Stephanotis mucronata (Blanco) Merr., is a potential immunosuppressant. The purpose of this study was to investigate the synergetic effects of STA and cyclosporine A (CsA) on T-cell response. Materials and Methods: First, the synergetic effects of STA and CsA were investigated in vitro on the cell proliferation, CD25 surface expression and cytokine IL-2 production of concanavalin A (Con A)-induced T-cells by MTT method, flow cytometric analysis and ELISA, respectively. Furthermore, 2,4-dinitrofluorobenzene (DNFB)-induced delayed-type hypersensitivity (DTH), a T-cell-mediated response in mice was used to evaluate the synergetic effects of STA and CsA in vivo. Finally, the direct effect of STA on CYP3A4, which is the predominant enzyme for metabolism of CsA was determined using P450-Glo™ CYP3A4 screening system. Results: The results showed that Con A-induced T-cells proliferation, IL-2 production and CD25 expression were not inhibited by low-dose STA (1 μM) or CsA (1 nM) alone but was significantly reduced by the combination of STA and CsA. The DNFB-induced mice ear swelling, hyperplasia and infiltration of inflammatory cells were also significantly diminished by the combined treatment with non-therapeutic dose of STA (1 mg kg–1) and CsA (0.5 mg kg–1). In addition, STA at the concentration of more than 0.1 μM significantly decreased CYP3A4 activity. Conclusion: The STA synergized the inhibitory effects of CsA on T-cell response in vitro and in vivo. These effects were attributable to its different and complementary molecular mechanisms and may partly due to its increasing of the bioavailability of CsA via inhibiting CYP3A4.
  Zheng-Rong Zhao , Shi-Fang Xu , Ping Zhang , Hua Liu , Yue-Guo Wu , Gui-Jiao Zhou , Yi-Heng Cai , Ju-Run Zhao and Feng-Yang Chen
  Background and Objective: Dendrobium devonianum and Dendrobium officinale are widely used as Chinese medicinal materials and health foods. These two species have similar appearances and chemical constitutions. However, their immunomodulating activities have never been compared. This study aims to investigate and compare the immunomodulating activities of D. devonianum and D. officinale. Materials and Methods: Ten batches of D. devonianum and D. officinale were collected from different regions. The botanical origins of the species were authenticated by DNA sequence analysis and the total polysaccharide contents were determined to guarantee the quality of each batch. Their immunomodulating activities were evaluated and compared in vitro and in vivo by splenocytes proliferation and hydrocortisone-induced immunosuppressed mice, respectively. Results: The two species have significant different sequences of DNA ITS region but with very close polysaccharide contents. In vitro study showed that the aqueous extracts of the 10 batches of D. devonianum and D. officinale significantly stimulated splenocyte proliferation with no differences in efficiencies. Furthermore, oral administration of D. devonianum or D. officinale not only significantly alleviated hydrocortisone-induced leukopenia and spleen and thymus atrophy but also significantly increased macrophage phagocytosis and delayed-type hypersensitivity response (DTH) in mice. Conclusion: Dendrobium devonianum and D. officinale regulated the innate and adaptive immune responses in vitro and in vivo with no differences in efficiencies.
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