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Articles by Fei Xue
Total Records ( 3 ) for Fei Xue
  Yong Zhao , Fei Xue and Yanxue Zhang
  Remote attestation is the key technology of trusted cloud computing. The existed remote attestation schemes are not sufficient to consider the trusted measurement of the running virtual computing node. In this study, by the analysis and comparison of existing remote attestation schemes, we propose a trusted measurement of the running virtual computing node and a threshold remote attestation scheme based on the trusted measurement results. By RO security analysis and a simulation, we verify the security and efficiency of the scheme. The trusted measurement of the running platform is mainly based on the trusted measurement of the programs running on the platform and a total trust value of the platform by an algorithm. The Threshold remote attestation for trusted measurement of the running platform is based on K-CCA problem.
  Xiaoyu Xue , Hongwei Yu , Haitao Yang , Fei Xue , Zhixin Wu , Wei Shen , Jun Li , Zhe Zhou , Yi Ding , Qi Zhao , Xuejun C. Zhang , Ming Liao , Mark Bartlam and Zihe Rao
  Coronaviruses (CoVs) can infect humans and multiple species of animals, causing a wide spectrum of diseases. The coronavirus main protease (Mpro), which plays a pivotal role in viral gene expression and replication through the proteolytic processing of replicase polyproteins, is an attractive target for anti-CoV drug design. In this study, the crystal structures of infectious bronchitis virus (IBV) Mpro and a severe acute respiratory syndrome CoV (SARS-CoV) Mpro mutant (H41A), in complex with an N-terminal autocleavage substrate, were individually determined to elucidate the structural flexibility and substrate binding of Mpro. A monomeric form of IBV Mpro was identified for the first time in CoV Mpro structures. A comparison of these two structures to other available Mpro structures provides new insights for the design of substrate-based inhibitors targeting CoV Mpros. Furthermore, a Michael acceptor inhibitor (named N3) was cocrystallized with IBV Mpro and was found to demonstrate in vitro inactivation of IBV Mpro and potent antiviral activity against IBV in chicken embryos. This provides a feasible animal model for designing wide-spectrum inhibitors against CoV-associated diseases. The structure-based optimization of N3 has yielded two more efficacious lead compounds, N27 and H16, with potent inhibition against SARS-CoV Mpro.
  Qi Zhao , Shuang Li , Fei Xue , Yilong Zou , Cheng Chen , Mark Bartlam and Zihe Rao
  The newly emergent human coronavirus HKU1 (HCoV-HKU1) was first identified in Hong Kong in 2005. Infection by HCoV-HKU1 occurs worldwide and causes syndromes such as the common cold, bronchitis, and pneumonia. The CoV main protease (Mpro), which is a key enzyme in viral replication via the proteolytic processing of the replicase polyproteins, has been recognized as an attractive target for rational drug design. In this study, we report the structure of HCoV-HKU1 Mpro in complex with a Michael acceptor, inhibitor N3. The structure of HCoV-HKU1 provides a high-quality model for group 2A CoVs, which are distinct from group 2B CoVs such as severe acute respiratory syndrome CoV. The structure, together with activity assays, supports the relative conservation at the P1 position that was discovered by sequencing the HCoV-HKU1 genome. Combined with structural data from other CoV Mpros, the HCoV-HKU1 Mpro structure reported here provides insights into both substrate preference and the design of antivirals targeting CoVs.
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