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Articles by Fayaz Ahmad
Total Records ( 3 ) for Fayaz Ahmad
  Iram Abdullah , Hidayatullah Tak and Fayaz Ahmad
  Giardiasis is a gastrointestinal disease caused by protozoan parasite Giardia intestinalis. It is known to infect a wide range of mammals including humans. The present study was carried out to study the impact of Giardiasis on hematological parameters of children in district Anantnag of Kashmir valley, India. The study was carried out on 268 children of both gender whose stool samples were processed through Direct Smear method and Formol Ether concentration technique. After confirming their results for Giardiasis, certain examinations of blood parameters were then carried out for 44 children which included total leukocyte count, differential leukocyte count, Hemoglobin and hematocrit values. Hemoglobin value and hematocrit values were estimated by Sahli’s Acid Hematin method and Wintrobe’s method, respectively. The white blood cell (WBC) count was done with the help of hemocytometer and differential counting was done by using Leishmann’s staining method. Finally data was analysed by Minitab software and Student’s t-test was used to determine the significance of difference between mean values in each group. The results showed a significant decrease in mean values of hemoglobin from 11.15±1.23 to 10.05±2.04 in males and 11.36±1.15 to 10.08±0.80 in females. The mean values of hematocrit also showed a decrease in their values between infected and uninfected children from 36.2±1.72 to 32.6±2.80 in males and 36.14±1.19 to 32.22±1.62 in females. In case of WBC count, a significant increase in the total number of WBCs was observed in case of infected children from 7.96±0.33 to 9.38±0.61. With respect to differential leukocyte count, eosinophils showed a marked increase in their number in infected individuals (5.0±0.71) in comparison to uninfected ones (3.2±0.44) while slight differences were noticed in case of other white blood cells which were not statistically significant. The results showed that Giardiasis is responsible for decrease in hemoglobin and hematocrit values and increase in total leukocyte count in infected children.
  Bina S. Siddiqui , Fouzia A. Sattar , Fayaz Ahmad and Sabira Begum
  Studies on the chemical constituents of the fruits of Morinda citrifolia Linn. have led to the isolation of two new compounds, morinaphthalene (=1,3,6,7-tetrahydroxy-2-hydroxymethyl-1,2,3,4-tetrahydronaphthalene, (1); and morindafurone (=5-hydroxy-1,10b-dihydro-6H-anthra [1,9-bc] furan-6-one, (2); as well as two known constituents, 1,8-dihydroxy-6-methoxy-3-methyl-9-anthrone (3) and 2,4-dimethoxy-9-anthrone (4). Their structures were elucidated by spectral analysis including 2D NMR techniques.
  Sajad Hussain Mir , M.M. Darzi , Fayaz Ahmad , M.Z. Chishti and M.S. Mir
  An experiment was conducted to study the efficacy of glimepiride (a new sulphonylurea) on the biochemical values and histomorphological features of streptozotocin-induced diabetic rabbits. Eighteen New Zealand white male rabbits were selected for the study. The rabbits were randomly divided into three Groups of six each. Group I was kept as normal healthy control (NC), Group II and Group III were made diabetic by single intravenous administration of streptozotocin (@ 65 mg/kg. b.w.). Glimepiride was given to Group III rabbits by gavage @ 2mg/kg. b.w. daily for twenty-one days whereas Group I and Group II rabbits received normal saline in the similar manner. The results indicated a significant decrease in the blood sugar (P<0.01), blood urea (P<0.001) and serum creatinine (P<0.001) in Group III rabbits. Further, the histomorphological study showed an increase in the percentage of beta cells in pancreatic islets and recovery of renal tubules in Group III rabbits. The findings indicate that glimepiride improves the biochemical values and ameliorates the histopathology of diabetic rabbits particularly restoring the morphology of beta cells of islets of Langerhan`s and thus, seems to be encouraging.
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