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Articles by Fawziah A. Al-Salmi
Total Records ( 2 ) for Fawziah A. Al-Salmi
  Fawziah A. Al-Salmi , Rasha Al-Eisa , Reham Z. Hamza , Howayda E. Khaled and Nahla S. El-Shenawy
  Background and Objective: Sodium Valproate (SV) is a medicine that is used to treat epilepsy and to prevent headache. In this study, L-cysteine (LC) was used to decrease the stress and biochemical variations induced by SV treatment. The present study investigated the defensive actions of LC vs, SV that induced testicular impairment. Materials and Methods: The rats were split into six groups (n = 10) as following: 1st control animals were saline-treated, 2nd and 3rd groups were administrated two doses of SV (100 and 500 mg kg1 b.wt.) presenting low and high doses, respectively, 4th group was treated with 100 mg kg1 of LC, in addition 5th and 6th groups were treated with SV-LD+LC and SV-HD+LC, respectively. The experiment was run for 30 successive days. Weights of the testis, serum testosterone, testicular oxidative/anti-oxidant capacity and histopathological damage scores of testis were recorded. Results: The SV group had significantly increased the tissue oxidative stress markers and significantly declined all antioxidant enzymes activities as compared to the control group. When the animals treated with combination of LC and any dose of SV, levels of oxidative parameters significantly declined, as well as the anti-oxidant significantly elevated compared to the SV-LD and SV-HD groups. The Johnsen's testicular score values showed improvement when LC was co-treated with the SV. Conclusion: Current results indicated that LC had partial protective effects against SV-induced testis damage at the biochemical and histopathological levels that could be due to the enhanced tissue anti-oxidant capacity.
  Reham Z. Hamza , Fawziah A. Al-Salmi and Nahla S. El-Shenawy
  Background and Objective: The potential benefit of green synthesis zinc oxide nanoparticles (ZnO NPs) is still a deprecatory issue. The aim of the present research was to elucidate the anti-hyperlipidemia of green tea leaves extract (GTE)/ZnO NPs complex against monosodium glutamate (MSG). Materials and Methods: Eight different groups of male rats were used: Group I was the control, group II received GTE (1 mg mL–1), group III was treated with ZnO NPs (10 mg kg–1), groups IV and V received MSG in two different doses (6.0 and 17.5 mg kg–1), group VI treated with ZnO NPs/GTE complex, groups VII and VIII were given ZnO NPs/GTE complex plus MSG in different doses. The effect of ZnO NPs/GTE complex against MSG toxicity through studying the alteration of enzyme activity of liver functions [alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alkaline phosphatase (ALK) and γ-glutamyl transferase (γ-GT)] and lipid profile alternation have been described. The rats that were given MSG only had a highly significant elevation in liver enzymes and severe lipid metabolism changes. Results: The findings for group VII and VIII clarify the efficacy of ZnO NPs/GTE complex as a hepato-protectant on MSG alone through improving the liver enzyme activity along with the lipid profile. The activities of ALT, AST, LDH, ALP and γ-GT in the serum were significantly reduced. Conclusion: ZnO NPs/GTE complex was proved to be a potential hepatoprotective as it significantly ameliorates the hepatotoxicity induced by MSG through hyperlipidemia reducing effect.
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