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Articles by Fawzi Irshaid
Total Records ( 3 ) for Fawzi Irshaid
  Fawzi Irshaid and Kamal Mansi
  Problem statement: Urtica pilulifera L. (Urticaceae), has long been used for the treatment of various aliments including diabetes. Diabetes is a metabolic disorder characterized by hyperglycemia which has a deleterious effect on all systems including reproductive system of animals. Therefore, the current study was designed to investigate the effects of Urtica pilulifera on the reproductive system of diabetic rats. Approach: Forty male rats were evenly divided into four groups: Group I consisted of non-diabetic rats that received only the vehicle; group II-IV was injected intraperitonially with a single dose of streptozotocin (STZ) of 70 mg kg-1; groups III and IV were given methanol extract of Urtica pilulifera orally, 3 days after the STZ injection, at daily doses of 1.0 and 2.0 g kg-1, respectively. After 4 weeks of treatments, all the rats were sacrificed. Results: Administration of 70 mg kg-1 of streptozotocin to male rats induced diabetes and significantly reduced the body and sex organ weights, testosterone levels, sperm count and motility and significantly increased the glucose levels and water and food intake. By contrast, rats given the Uritica pilulifera methanol extract had significantly improved body weight gain, whereas the glucose levels, water and food intake significantly improved in treated diabetic male rats. In addition, this extract improved the reproductive system of the diabetic male rats by significantly increasing the testis and epididymis weights, testosterone levels, sperm count and motility. Conclusion/Recommendations: We concluded that the adverse effects of STZ-diabetes on reproductive system of male rats can be reversed by treatment with Urtica pilulifera leaf extract; and this leaf extract exhibits antihyperglycemic and spermatogenic activities. Based on these findings, we suggested the possible utilization of Urtica pilulifera extracted as a therapy to prevent the development of diabetes in later life and improved the performance of male reproductive system in animals and humans.
  Khaled A. Tarawneh , Fawzi Irshaid , Adnan S. Jaran , Magda Ezealarab and Khaled M. Khleifat
  The objective of this study was to assess the antibacterial and antioxidant activities of methanolic extracts obtained from aerial parts of four medicinal plants: Achillea fragrantissima, Teucrium polium L., Rosmarinus officinalis and Alhgi graecorum. Both broth dilution and disc diffusion methods were used to assess the antibacterial activity of these extracts against several numbers of bacterial isolates. Antioxidant activity of these extracts was measured for the first time in vitro by 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid (ABTS) method and expressed as Trolox Equivalent Antioxidant Capacity (TEAC). All extracts exhibit antibacterial activity in dose-dependent manner against Gram negative and Gram positive bacteria. MIC were found between 1.2-2.9 mg mL-1 for Achillea fragrantissima, 1.2-2.7 mg mL-1 for Teucrium polium, 1.1-1.8 mg mL-1 for Alhgi graecorum and 0.9-1.7 mg mL-1 for Rosmarinus officinalis against the tested bacteria. On other hand, the Rosmarinus officinalis exhibited the best ABTS scavenging capacity (424 mmoL g-1 dry matter), followed by Achillea fragrantissima (192 mmol g-1 dry matter). The lowest ABTS scavenging capacities were obtained from Teucrium polium and Alhgi graecorum, 174 and 172 mmoL g-1 dry matter, respectively. Similarly, Rosmarinus officinalis exhibited the highest antioxidant activity when IC50 (21 μg mL-1 extract) was measured, followed by Achillea fragrantissima (69 μg mL-1 extract), Teucrium polium (80 μg mL-1 extract) and finally Alhgi Graecorum (103 μg mL-1 extract). In conclusion, our plant extracts exhibited both antibacterial and antioxidant activities with Rosmarinus officinalis showing the most antibacterial and antioxidant activities. Thus, our results may, in part, support the traditional use of these plant species for medicinal purposes.
  Fawzi Irshaid and Kamal Mansi
  This research was carried out to examine the effects of methanol leaf extract of U. pilulifera on some hematological and biochemical parameters in diabetic rats. Forty rats weighting 150-185 g were divided into four groups: group I treated with a vehicle (control); group II including diabetic rats treated with a vehicle; groups III and VI including diabetic rats treated with 1.0 and 2.0 g kg-1 of the extract for 3 weeks, respectively. Rats were made diabetic by injection with a single dose of streptozotocin (70 mg kg-1, i.p). At the end of the experimental period, rats were killed and blood samples were taken for biological analysis. The blood glucose level, Erythrocyte Sedimentation Rats (ESR), Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), urea and creatinine levels significantly increased in diabetic rats as compared to control. By contrast, significant reduction of the erythrocyte and leukocytes counts and Pack Cell Volume (PCV), Thyroxine (T4) and Triiodothyronine (T3) and Thyroid Stimulating Hormone (TSH) levels in diabetic group were also noticed in diabetic rats as compared to control. Treatment of diabetic rats with this extract caused a significant decrease in blood glucose levels, ESR, urea and creatinine, whereas ALT and AST slightly lowered. In addition, in diabetic treated groups, the erythrocyte and leukocyte counts and PCV, T3, T4 and TSH values significantly increased, whereas the leukocyte count slightly increased. We can concluded that U. pilulifera extract improves the diabetic status in terms of blood sugar and alleviates the diabetes-induced disturbances of some hematological and biochemical parameters of rats.
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