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Articles by Fauziah Othman
Total Records ( 3 ) for Fauziah Othman
  Mohd Fadzelly Abu Bakar , Arnida Hani Teh , Asmah Rahmat , Fauziah Othman , Normah Hashim and Sharida Fakurazi
  Regarding to the promising pharmacotherapeutic properties of Strobilanthes crispus (Acanthaceae) plant, we report here, the development of nutraceutical herbal tea from S. crispus young and old leaves and evaluate the potential antiproliferative properties and antioxidant activity in vitro. Unfermented and fermented tea (Camellia sinensis) preparation was applied for development of S. crispus tea. Antiproliferative properties of S. crispus tea extracts were determined by the microculture tetrazolium salt (MTT) assay against human breast cancer cell lines (hormone dependent, MCF-7; non-hormone dependent, MDA-MB-231). The results showed that S. crispus tea only inhibit the proliferation of human hormone dependent breast cancer cell lines (MCF-7) but not the non-hormone dependent breast cancer cell lines (MDA-MB-231). The antioxidant activity was determined using FRAP (Ferric Reducing/Antioxidant Power) and DPPH free radical scavenging assay. The results showed that the hot water extract of S. crispus tea showed high antioxidant activity especially S. crispus unfermented tea from old leaves. But the tea from the leaves of C. sinensis displayed better antioxidant activity.
  Suherman Jaksa , Asmah Rahmat , Fauziah Othman , Patimah Ismail and Siti Muskinah Hj. Mansor
  The administration effect of Strobilanthes crispus extract (SC) during hepatocarcinogenesis was studied to investigate the possible cancer suppressive effect of the component existed in the leaves. The rats (84 male Sprague Dawley) were divided into 14 groups N (Normal), C (Cancer), NS 1 (Normal+ SC 1%), NS 2.5 (Normal+SC 2.5%), NS 5 (Normal+SC 5%), NS 7.5 (Normal+SC 7.5%), CS 1 (Cancer+SC 1%), CS 2.5 (Cancer+SC 2.5%), CS 5 (Cancer+SC 5%), CS 7.5 (Cancer+SC 7.5%), CG 1 (Cancer+Glycyrrhizin 1%), CG 2.5 (Cancer+Glycyrrhizin 2.5%), CG 5 (Cancer+Glycyrrhizin 5%), and CG 7.5 (Cancer+Glycyrrhizin 7.5%). 1, 2.5, 5 and 7.5% (w/v) of S. crispus extract were used, compared with Glycyrrhizin, the commercial anticancer drug used mainly for liver. Administration effect during liver cancer in rats that have been induced with cancer by diethylnitrosamine (DEN) and 2-acetyl-aminoflourence (AAF) was studied by estimation of glutathione S-transferase (GST) and uranyl diphosphate glucoronyl transferase (UDPGT) in liver. The severity of neoplasia in induced liver cancer was also evaluated by histological examination. Treatment with DEN/AAF caused increase in all enzyme activities measured when compared to control. Significant differences were observed among all the treatment groups for GST and UDPGT activities. Histological evaluations showed the loss of normal morphology and organizations of hepatocytes when carcinogens were introduced into the rats. The severity of liver cell dysplasia was evidently decreased by SC extract treatment group as compared to glycyrrhizin. Furthermore SC did not affect the normal organization in the liver. The findings suggest that supplementation of SC on DEN/AAF rats reduced the severity of hepatocarcinogenesis.
  Manal Mohamed Elhassan Taha , Siddig Ibrahim Abdel Wahab , Fauziah Othman , Parichehr Hanachi , Ahmad Bustamam Abdul and Adel Sharaf Al-Zubairi
  The aim of the current study is to determine the effects of A. indica aqueous extract on Diethyl Nitrosamine (DEN) and 2-Acetylaminofluorene (AAF) induced-hepatocarcinogenesis on Spraque-Dawley rats. The plant, A. indica, extract was prepared into 5% w/v in distilled water. Spraque-Dawley male rats were divided into 3 groups of 7 rats each. The groups were: DEN/AAF-induced rats (C), DEN/AAF-induced rats treated with 5% A. indica (CAI) and normal control group (N). In situ detection of DNA fragmentation, TUNEL assay, was used to investigate the apoptogenic properties of A. indica. RT-PCR was used to amplify AFP mRNA. TUNEL assay supported that there was more numbers of apoptotic cells in the liver of (CAI) group compared with (C) group. AFP gene was suppressed by the supplementation of A. indica to DEN/AAF rats (CAI). A. indica (Neem) has revealed a chemopreventive capability by regressing the hepatocarcinogenesis induced by DEN/AAF carcinogens. This capability can be seen from the modulating effects of the plant in the biological indicators used in this study.
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