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Articles by Fatmagul YUR
Total Records ( 2 ) for Fatmagul YUR
  Mete Yazar , Yeter Deger and Fatmagul Yur
  It is considered several cytokines are effective in pathogenesis and theraphy of diabetes mellitus. The aim of this study was to investigate serum concentrations of interleukin-1β, interleukin-2, interleukin-6 and interleukin-10 cytokines thought to have relationship with diabetes mellitus and serum retinol, α-tocopherol and vitamin D3 levels notified they have constructive effects on diabetes in streptozotocyne induced diabetic rats. Male Wistar-Albino rats between 7-8 weeks old and weighing 180-210 g were used. Streptozotocin induced and blood glucose levels were found between 230-390 mg dL-1 diabetic 25 rats formed the study group and 15 healthy rats constituted the control group. Serum cytokine levels in both groups were evaluated by solid phase sandwich ELISA method and serum vitamin levels were established by HPLC. Serum interleukin-1β, interleukin-6 and interleukin-10 levels were not sufficient to constitute a statistical importance between groups. However, in diabetic group decreased interleukin-2 levels (p≤0.05) were established. Besides, decreased retinol and vitamin D3 levels (p≤0.05) were detected in diabetic group but reduction in levels of α-tocopherol did not reach statistical significance. In conclusion, decreased serum interleukin-2 levels established in diseased group may indicate this cytokine has a part in the pathogenesis of diabetes mellitus and reduced vitamin levels may exhibit they used for disposal of free oxygen radicals. Besides, increased vitamin D3 consumption may be due to its disposal in T cell regulation.
  Handan MERT , Ibrahim YORUK , Yeter DEGER , Nihat MERT , Semiha DEDE and Fatmagul YUR
  The aim of the present study was to determine serum concentrations of the products of nitric oxide oxidation (nitrate and nitrite) and some vitamins (retinol acetate, α- and δ-tocopherol, and vitamin D3) in sheep naturally infected withBabesia ovis . The investigation included 30 infected and 10 control sheep. Serum α-tocopherol levels were significantly lower (P < 0.05), and nitrate and nitrite concentrations were significantly higher (P < 0.05) in infected animals than in controls. It is thought that the elevated nitrate and nitrite levels of the sheep infected with babesiosis were due to the result of damage caused by Babesia. On the other hand, a significant decrease was observed in α-tocopherol levels in sheep with babesiosis because of damage and pathophysiological changes to erythrocytes.
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