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Articles by Faten Zahran
Total Records ( 1 ) for Faten Zahran
  Ehab Tousson , Faten Zahran and Mohamed A. Shalapy
  Background and Objective: Because of their muscle-building and growth-enhancing properties, anabolic androgenic hormones are still illegally administered to food-producing animals. Boldenone is an anabolic androgenic synthetic commercial steroid. The present study was designed to investigate the possible effect of Moringa Leaf Extract (MLE) and Ginkgo Leaf Extract (GLE) on the changes in the structure and functions of rat testes after boldenone injections. Materials and Methods: A total of 48 male albino rats weighing 170-200 g and of 10-12 weeks age were divided into 6 groups (8 animals each). First control group includes rats that injected intramuscularly with olive oil. Second and 3rd groups were animals received MLE (intragastrically, 200 mg kg–1 b.wt.) and GLE (intragastrically, 200 mg kg–1 b.wt.) respectively. Fourth experimental group include rats that received intramuscular injections of boldenone undecylenate at (5 mg kg–1 b.wt.) for 12 weeks, 5th and 6th groups where animals intramuscular injected with boldenone and treated with MLE or GLE at the same time respectively. Results: The obtained results indicate that testosterone, testicular MDA and nitric oxide were significantly increased in boldenone group when compared with control group. Also, catalase, super oxide dismutase and total thiol in testicular tissue were significantly decreased in boldenone group when compared with control group. Moreover, increased testosterone levels with biochemical indicators of testicular damage and histopathological and cytokeratin-immunoreactivity alterations supported this conclusion. Conclusion: It has also been shown that the co-treatment with GLE or with MLE provided significant prophylactic treatment from the testicular damage of boldenone.
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