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Articles by Fatemeh Aliakbari
Total Records ( 2 ) for Fatemeh Aliakbari
  Abdoljalal Marjani , Fatemeh Aliakbari and Mohammad Zaman Kamkar
  The aim of this study was to evaluate the body mass index dependent metabolic syndrome in severe mental illness patients in Gorgan. A total of 267 severe mental illness patients took part in this study. The prevalence of metabolic syndrome in severe mental illness patients in different body mass index were 6.67, 24.09 and 53.06%. There were significant differences in the mean of waist circumference, HDL-cholesterol, triglyceride and fasting blood glucose in subjects with metabolic syndrome in different body mass index when compared with subjects without metabolic syndrome (p<0.05). The prevalence of high fasting glucose, low high density lipoprotein-cholesterol, high triglyceride levels, high waist circumference and high blood pressure were 14.23, 38.57, 41.57, 32.96 and 5.24%, respectively. It shows that high triglyceride levels (41.57%) and Low HDL-cholesterol levels (38.57%) were the most frequent characteristics in comparison to other metabolic components. Our results show that, 26.96, 31.08, 21.35, 15.35 and 5.25% of subjects had zero, one, two, three and four criteria for metabolic syndrome, respectively. These results show that the prevalence of metabolic syndrome in severe mental illness patients in Gorgan is increased with elevated body mass index. The results of this study suggest that mental illness patients are at risk of metabolic syndrome, when the rate of body mass index increases. Risk factors such as high triglyceride level and low HDL-cholesterol may play an important role in the occurrence of metabolic syndrome in severe mental illness patients.
  Elham Zarei , Hassan Mohajery , Fatemeh Aliakbari , Fatemeh Mohammad Zadeh , Gholamreza Veghari and Azadreza Mansourian
  Background and Objective: Polycystic ovary syndrome (PCOS) is shown to be associated with hyperandrogenemia and has some features such as cytotoxic T-cells activation and release of perforin and granzyme-B. Present work was aimed to investigate the relation of perforin and granzyme-B to androgenic state in PCOS. Materials and Methods: Forty three PCOS and 40 control women were recruited. After recording demographic data, sex hormone status and cardiovascular disease (CVD) risk factors were evaluated. Perforin and granzyme-B levels were measured using sandwich ELISA kits. Results: Sex hormone binding globulin (SHBG) levels were lower in patients. Luteinizing hormone (LH), free testosterone (FT), dehydroepiandrosterone sulfate (DHEA-S), free androgen index (FAI), perforin and granzyme-B values were higher in PCOS group. Perforin and granzyme-B were positively correlated with FT and FAI and with each other in PCOS group. In patients, granzyme-B and perforin were related with FT and FAI, respectively. Conclusion: The results of present study together with evidences about the release of pro-inflammatory cytokines in insulin resistance, CVD and PCOS suggest that perforin/granzyme-B may be involved in interactions of sex hormones system in PCOS patients.
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