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Articles by Farque Ahmed
Total Records ( 2 ) for Farque Ahmed
  Farque Ahmed , Abu Sayeed , Anwarul Islam , S. M. Abdus Salam , Golam Sadik and G. R. M. Astaq Mohal Khan
  The ethyl acetate (C2H5COOCH3) extract of the roots of Vanda roxburghii Br. is known to have a significant antimicrobial activity. The investigation was carried out on the C2H5COOCH3 extract for the isolation and characterization of the active principle (s). The extract afforded a glycoside, 17-β-hydroxy-14, 20-epoxy-1-oxo- [22R]-3β-[O-β-D-glucopyranosyl]-5,24-withadienolide (VR-2), the structure of which was elucidated on the basis of spectral evidences. Compound VR-2 was screened against a wide variety of pathogenic bacteria and fungus for its antimicrobial activity by disc diffusion method. The compound showed significant antibacterial activity against most of the tested strain of bacteria and produced zone of inhibition between 14 to 28mm. The compound also showed significant antifungal activity and the minimum inhibitory concentration (MIC) of VR-2 against Bacillus cereus, Bacillus subtilis, Escherichia coli, Shigella dysenteriae and pseudomonus aeruginosa was determined and the values were 8, 32, 16, 8 and 16μg ml-1, respectively.
  Farque Ahmed , Abu Sayeed , Anwarul Islam , S.M. Abdus Salam , Golam Sadik , M.A. Sattar and G.R.M. Astaq Mohal Khan
  The petroleum ether, ethyl acetate and methanol extracts of Vanda roxburghii as well as glycoside, melianin (VR-1) isolated from it were screened for antimicrobial activity against a wide variety of bacteria and fungi. The ethyl acetate and methanol extracts showed moderate antibacterial activity against almost all the tested organisms. The compound melianin (VR-1) exhibited strong activity against all the tested organisms and produced zone of inhibition between 17 and 27 mm. The petroleum ether extract was found comparatively less active against the organisms. All the tested materials showed antifungal activity against Aspergillus fumigatus, Candida albicans, Hensinela californica and Rhizopus arijae. The minimum inhibitory concentrations (MIC) of melianin against Bacillus cereus, Bacillus subtilis, Escherichia coli and Shigella dysenteriae were 32, 64, 64 & 128 μg ml–1 respectively. The findings may provide the basis for traditional use of this plant in the treatment of infectious diseases.
 
 
 
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