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Articles by Farman Ali Siyal
Total Records ( 2 ) for Farman Ali Siyal
  Jan Muhammad Shah , Taufique Ahmed Qureshi , Tahmina Sayed , Qurban Ali Shah , Ilahi Bux Kalhoro , Muhammad Asif Arain , Muhammad Saeed , Farman Ali Siyal and Zohaib Ahmed Bhutto
  Objective: The aim of current study was to evaluate the therapeutic and high doses of florfenicol (FFC) on hematological values in goats. Methodology: Goats were intramuscularly induced with therapeutic (20 mg kg –1 b.wt.) and high doses (40 and 60 mg kg –1 b.wt.) of florfenicol for 3 days with 24 h interval. The blood samples were drawn at different timings from 0-120 h after drug administration and were assayed for the selected hematological parameters. Results: The therapeutic dose of FFC produced no effect on erythrocytes, hemoglobin, packed cell volume and leukocytes indices at all timing points, whereas decreased the lymphocyte count (p<0.05) at 24 h. The high dosages of FFC produced significant effect on erythrocytes, hemoglobin, packed cell volume, leukocytes and lymphocyte indices. In comparison with control, erythrocytic count and hemoglobin level (p<0.05) decreased from 48-72 h. Packed cell volume was observed to be reduced (p<0.05 and p<0.01) for 72 h. The leukocytic count (p<0.05) diminished from 24-72 h. The lymphocytic count decreased (p<0.05 and p<0.01) for 96 h. Clinically, local discomfort, reactions and pain at site of injection and some digestion disturbance were also noticed with high doses of florfenicol during experiment. Conclusion: It was concluded that both the therapeutic and high doses of florfenicol significantly affects the lymphocytes. The high doses of FFC produced anemic and immunosuppressive effects of drug.
  Asif Mehfooz , Quanwei Wei , Mohamed Babo Fadlalla , Farman Ali Siyal , Kuldeep Dhama , Dagan Mao and Fangxiong Shi
  Background and Objective: Restraint stress and hypothyroidism impair animal testicular functions. As stress is increasing gradually in our daily life, there is an increased chance of the occurrence of both stress and hypothyroidism together. Therefore, this study was designed to evaluate the effect of restraint stress on growth performance and testicular cells apoptosis in adult hypothyroid mice. Methodology: Twenty-four adult male mice were divided into four groups: control, Restraint Stress (RS), hypothyroid (HT) and RS+HT. ANOVA followed by Tukey as post hoc tests were used to determine the difference between multiple groups. Results: The results indicated that the feed and water index, body weight and testes weight, serum concentration of T3, T4 and testosterone exhibited a reduction but the TSH levels were increased in all experimental groups compared to the control. Histological observations of the testis from different experimental groups exhibited considerable interstitial edema, broken basement membrane and increased interstitial spaces compared with the control group. Seminiferous tubules were also morphologically shrinkage and deformed in RS+HT group compared to control group. Obvious suppression of spermatogenesis by restraint stress, the degenerative population of round spermatids was markedly increased due to apoptosis in the lumen of RS group as compared to the control group. Moreover, leydig cells, blood vessels, sertoli cells, primary and secondary spermatocytes are absent in large numbers and exposing apoptosis in RS+HT mice than RS and HT mice as compared to the control mice. Conclusion: Restraint stress and hypothyroidism together have adverse effects on male fertility based on increasing of the apoptotic process.
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