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Articles by Fang Zhang
Total Records ( 2 ) for Fang Zhang
  Shan Sun , Fang Zhang , Shanshan Zhang , Tieling Xing and Shenzhou Lu
  Current surgical dressings and woundplast have drawbacks such as poor permeability, airtightness and biocompatibility, thus a new material is obligatory to replace the traditional ones. Due to outstanding biocompatibility of Silk Fibroin (SF) and excellent antibacterial properties of Dodecyl Trimethyl Ammonium Bromide (DTAB), a cationic surfactant, the SF/DTAB hydrogel formed instantaneously is recommended. By means of SEM, FTIR and XRD, SF/DTAB hydrogel displayed clustered nanofilaments structure and similar secondary structure and morphology with SF solution mainly consisted of random coils in 1 h, then it tended to be the same as pure SF hydrogel which was composed of porous network structure and primarily contained β-sheet structure. Excellent elasticity and antibacterial effect were verified by rheological and antibacterial measurements.
  Yuan-Hung Chien , Ning Jiang , Fang Li , Fang Zhang , Cheng Zhu and Deborah Leckband
  Micropipette manipulation measurements quantified the pre-steady state binding kinetics between cell pairs mediated by Xenopus cleavage stage cadherin. The time-dependence of the intercellular binding probability exhibits a fast forming, low probability binding state, which transitions to a slower forming, high probability state. The biphasic kinetics are independent of the cytoplasmic region, but the transition to the high probability state requires the third extracellular domain EC3. Deleting either EC3 or EC3–5, or substituting Trp2 for Ala reduces the binding curves to a simple, monophasic rise in binding probability to a limiting plateau, as predicted for a single site binding mechanism. The two stage cadherin binding process reported here directly parallels previous biophysical studies, and confirms that the cadherin ectodomain governs the initial intercellular adhesion dynamics.
 
 
 
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