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Articles by Fan Yang
Total Records ( 4 ) for Fan Yang
  Junlin Zhang , Yulei Wei , Mingming Qin , Fan Yang and Huayan Wang
  CAMA-syn, a hybrid composed of N-terminal α-helical segment of CA (amino acid 1-8) and N-terminal α-helical segment of MA (amino acid 1-12) is a novel small peptide with the potent antibacterial and synergistic activity without cytotoxicity. In order to test the antibacterial function of CAMA-syn produced specially in lung epitheliuml cells, several vectors containing the synthesized CAMA-syn DNA fragment initiated by CMV and Surfactant Protein C (SP-C) promoter were constructed and transfected into recipient cells. The results showed that CAMA-syn fusion to Green Fluorescent Protein (GFP) or to Hemagglutinin epitope (HA) tag was expressed in both 293 and A549 cells. The antibacterial assays of CAMA-syn were conducted against both Gram positive and negative bacteria including S. abortusovis, P. anatis, S. hyicus and S. suis. The results of colony forming efficiency and cell growth curves proved that the in vitro expressed CAMA-syn could inhibit the growth of bacterial, demonstrating that lung epithelial cell-specific expression of antimicrobial peptide CAMA-syn could have antibacterial activity.
  Wei Quan Zhang , Fan Yang and XiaoYun Li
  We present simultaneous phase matching of optical parametric oscillator (OPO) and difference frequency generation (DFG), using a noncollinear interaction in periodically poled crystal with single grating. Selecting proper grating period Λ and titled angle ξ between the grating vector G and the optical axis of crystal, the noncollinear scheme provides double phase matching solutions over continuous regions of the midwave infrared spectrum. At certain wavelength regions, for DFG process the group velocities between interaction pulses are matching and the phase matching bandwidth reaches maximum. Selecting the different grating period, the broadband midwave tuning and better gain spectrum can be obtained at different wavelength range. For the certain period grating the conversion efficiency is higher. Hence, using the double phase matching configuration, the broadband tunable midwave infrared wave can be produced in single grating. But the configurations have a relatively narrow angular bandwidth.
  Fan Yang , Xiao Ling Zhang , Kang Sun , Mo Jun Xiong , Ping Fang Xia , Zi Jian Cao and Zi Jian Cao
  A facile approach for synthesis of the triarylamine-endcapped X-branched oligofluorene, X-OF(2)Ph-NPh and its corresponding linear oligofluorene, OF(2)Ph-NPh by Suzuki cross-coupling as a key reaction has been developed. This novel X-branched oligofluorene exhibits much higher thermal and electrochemical stabilities and enhanced electroluminescent properties as comparison to its corresponding linear counterpart. Using a simple two-layer OLED structure of ITO/oligofluorene (40 nm)/PBD (40 nm)/LiF (1 nm)/Al (150 nm), the luminance efficiency of X-OF(2)Ph-NPh-based OLED can also reach up to 2.8 cd/A with a maximum brightness of 1700 cd/m2 and remarkably better than 1.2 cd/A with a maximum brightness of 700 cd/m2 for its corresponding linear oligofluorene OF(2)Ph-NPh-based OLEDs.
  An-Sheng Zhang , Fan Yang , Kathrin Meyer , Catalina Hernandez , Tara Chapman-Arvedson , Pamela J. Bjorkman and Caroline A. Enns
  HFE2 (hemochromatosis type 2 gene) is highly expressed in skeletal muscle and liver hepatocytes. Its encoded protein, hemojuvelin (HJV), is a co-receptor for the bone morphogenetic proteins 2 and 4 (BMP2 and BMP4) and enhances the BMP-induced hepcidin expression. Hepcidin is a central iron regulatory hormone predominantly secreted from hepatocytes. HJV also binds neogenin, a membrane protein widely expressed in many tissues. Neogenin is required for the processing and release of HJV from cells. The role that neogenin plays in HJV trafficking was investigated, using HepG2 cells, a human hepatoma cell line. Knockdown of endogenous neogenin markedly suppresses HJV release but has no evident effect on HJV trafficking to the plasma membrane. The addition of a soluble neogenin ectodomain to cells markedly inhibits HJV release, indicating that the HJV shedding is not processed before trafficking to the cell surface. At the plasma membrane it undergoes endocytosis in a dynamin-independent but cholesterol-dependent manner. The additional findings that HJV release is coupled to lysosomal degradation of neogenin and that cholesterol depletion by filipin blocks both HJV endocytosis and HJV release suggest that neogenin-mediated HJV release occurs after the HJV-neogenin complex is internalized from the cell surface.
 
 
 
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