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Articles by Faizah Othman
Total Records ( 2 ) for Faizah Othman
  Adel.A. Amran , Zaiton Zakaria , Faizah Othman and Paden Morat
  Problem statement: Oxidative stress plays a major role in hypercholesterolemia induced atherosclerosis. Garcinia atroviridis has been shown to exhibit antioxidant properties. Approach: The present study aimed to investigate the effect of Garcinia atroviridis on the oxidative stress in guinea pigs fed with high cholesterol diet. Twenty-four male Guinea pigs were divided into four groups. Group I served as control while group II, III, IV were fed with 1% cholesterol diet in rabbit chow pellet, fed with both 1% cholesterol diet plus 50 mg body-1 weight of Garcinia atroviridis, fed with Garcinia atroviridis only (50 mg mL-1 water body-1 weight), respectively. All animals were sacrificed by cardiac puncture and the blood was collected for the determination of malonaldialdehyde and DNA damage using comet assay and histology of the aorta was performed. Results: The results showed a significant increase in the percentage of DNA damage in the tail and in the tail moment (comet assay) in the group II compared to the group I. Group III showed pattern of reduction in the percentage of DNA damage by 42% and tail moment by 50% compared to the group II. There were no significant changes in the MDA levels in serum, liver and heart in all groups. Histological studies in group III showed a tendency in the reduction of the fat deposition in the aorta and number of foam cells compared to the group II. Conclusion: The supplementation with Garcinia atroviridis reduced the DNA damage and deposition of lipids in the wall of the aorta in hypercholesteromic guinea pigs.
  Kumeshini Sukalingam , Kamsiah Jaarin , Qodriyah Haji Mohd Saad , Suhaila Mohamed and Faizah Othman
  Background and Objective: Oxidative stress is connected with the pathogenesis of cardiovascular diseases. A series of deep-fat frying in dietary cooking oil produce more amount of reactive oxygen species. In this study, repeatedly heated palm oil and ADD-X were studied for its effect on the Blood Pressure (BP), lipid peroxidation and antioxidant parameters. Methodology: Thirty female Sprague-Dawley rats were divided into 5 groups with 6 rats each. All groups of the animals were ovariectomized after anesthetized. Group 1 was fed 2% cholesterol chow (Chol-C), groups 2 and 4, respectively fed 2% cholesterol chow along with 5 and 10 times heated palm oil (5 HPO and 10 HPO). Groups 3 and 5 were respectively given 2% cholesterol chow with 5 HPO and 10 HPO along with ADD-X. Duration of the feeding was 6 months. Systolic, diastolic and mean BP were monitored 4 weeks intervals using a non-invasive method. At the end of the study, blood was collected for oxidative stress and antioxidant parameters. Results: The BP was elevated significantly (p<0.05) in 10 HPO and 5 HPO groups, respectively, where the 10 HPO group viewing higher values. The Increased in BP was significantly lower in ADD-X treated groups. The level of thiobarbituric acid reactive substances (TBARS) was significantly increased in 5 HPO and 10 HPO treated animals and decrease antioxidant parameters compared to Chol-C animals. Consumption of ADD-X reduces TBARS and increase antioxidant enzymes. Conclusion: Repeatedly heated palm oil increases BP, lipid peroxidation and decrease antioxidant enzymes. Supplementation of ADD-X reversed the BP and reduce oxidative stress biomarkers in the post menopausal rat models.
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