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Articles by Faiz Batool
Total Records ( 2 ) for Faiz Batool
  Amjad Hameed , Faiz Batool , Tahira Iqbal , Tayyba Tabassum Baig and Javed Anver Qureshi
  This study was based on biodisposition kinetics of ofloxacin in Pakistani healthy female volunteers after oral administration. Ten healthy female volunteers were included in this study. The blood samples of each volunteer were collected after oral administration of ofloxacin. The concentration of ofloxacin in blood samples was measured by microbiological assay. The mean (SE) values of time to peak (tmax), peak concentration (Cmax), absorption half life (t1/2α), absorption rate constant (ka), elimination half life (t1/2), elimination rate constant (K10β), were 1.012 ± 0.176 h, 0.907 ± 0.126 μg ml-1, 0.516? 0.093h, 13.593?2.936L h-1, 2.996 ± 0.567h and 0.291 ± 0.693 L h-1 respectively. The mean (SE) values for area under curve (AUC), clearance (CL), volume of distribution (Vd) and mean resident time (MRT) were 4.358 ± 0.771 1itter, 53.470 ± 11.068 l h-1, 214.41?49.127 litter and 5.030 ± 0.705 h respectively. Values of parameters like, volume of distribution, total body clearance and absorption rate constant were higher, while elimination half life, AUC, Cmax, and tmax were lower in local population as compared with foreign studies. There was no influence of body surface area on total body clearance of ofloxacin (R2=0.0581). There was an increase in body clearance of ofloxacin (R2=0.2236) and area under curve (AUC) for ofloxacin (R2=0.258) with increasing body surface are of volunteers. Therefore body surface area of volunteers may slightly influence the total body clearance and area under curve for ofloxacin. These gender-related differences mainly low body weight and surface area in females may warrant dosage adjustments.
  Tayyba Tabassum Baig , Munir Ahmad Sheikh , Amjad Hameed , Amer Jamil , Faiz Batool , Shazia Muhammad Ali and Shafaqat Ali
  Filter Press Cake (Mud) was enriched with biomass protein using Arachniotus sp. as fermentative organism. The Mud was dewaxed for increased protein production before fermentation. Proximate analysis of native and biomass was done. It was found that after fermentation ash contents decreased from 17.50 to 16.00 % and fiber was decreased from 28 to 2%. Ether extract remained the same. Prior to the production of biomass protein certain conditions like fermentation period (72 h), substrate to water ratio (6%), (NH4)2SO4(0.1%), CaCl2.2H2O (0.025%), MgSO4.7H2O (0.015%), KH2PO4 (0.1%), Cane molasses (1.5%), and Corn Steep Liquor (2.0%) were optimized. These conditions were then applied to produce biomass protein on large scale. The biomass thus produced contained 26.25% crude protein, 13.12% true protein, 6.73% ether extract, 16% ash and 2% crude fiber. Amino acid analysis of biomass revealed the presence of 15 amino acids. The chemical score of protein was `0` and Leucine and Valine were first and second limiting amino acids respectively. The protein quality of biomass was tested in terms of digestibility that showed an average digestibility of 80.917%.
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