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Articles by Fahaid Al-Hashem
Total Records ( 5 ) for Fahaid Al-Hashem
  Fahaid Al-Hashem
  Problem statement: Aluminum has the potential to be toxic in humans and animals. Aluminum is present in many manufactured foods and medicines and also added to drinking water for purification purposes, thus increasing the human exposure to this toxic metal. Aluminum accumulates mainly in bone, liver, testis, kidneys and brain and resulted in biological dysfunctions. For this reason, many researches are carried out to find natural-made compounds that help in the protection against aluminum induced toxicity in human and animals. The present study was carried out to investigate the protective effects of Camel's milk against aluminum-induced biochemical alterations and oxidative stress in the liver and kidney of white albino rats. Approach: White albino rats of both sexes (230-250 g) were housed in standard metal cages (10 rats/cage). The experimental rats (10 in each group) distributed into two experimental groups with a shared control group received only normal saline orally (Group 1). In experimental first group, a daily dose (0.5 mg kg-1 body weight) of Aluminum chloride (AlCl3) was orally administrated to the rats for 30 days and named aluminum chloride-treated rats. In experimental second group, the same concentrations of Aluminum chloride was administered orally 10 min after the administration in 1 mL of early morning fresh Camel's milk into the experimental rats for the same period of time and named Camel's milk-Aluminum chloride treated group. Water and food were provided ad libitum. Results: Biochemical findings in this study showed that the oral administration of camels milk with Aluminum chloride for 30 days resulted in an significant decrease in the levels of serum urea, creatinine, bilirubin, total cholesterol, triglycerides , tramsaminases (AST and ALT), Alkaline Phosotase (ALP) and lactate dehydrogenase. And resulted in a significant increase in total protein and Albumin levels when these rats were compared to normal rats received Aluminum chloride in which all these parameters were altered. Administration of ALCl3 to rats resulted in a significant increase lipid peroxidation biomarkers: Thiobarbituric Acid Reactive Substances (TBARS) and Hydroperoxides. (TBARS) levels were significantly reduced in the liver and the kidney of rats treated with camels milk and ALCl3, also, hydroperoxides levels were reduced in the liver and the kidney of same Camel's milk and ALCl3 treated rats. The levels of reduced Glutathione (GSH) and the activities of antioxidant enzymes: Superoxide dismutase and catalase were significantly decreased in liver and kidney of rats treated with AlCl3 alone. The presence of Camel's milk with AlCl3 alleviated its effect on these antioxidant system components in rats. It caused a significant increase in the levels of GSH in the liver and kidney of the rats and a significant increase in the activity of SOD and CAT in the liver and the kidney. Conclusion: Our results demonstrated that Aluminum chloride (AlCl3) is capable to cause changes in some biochemical parameters, induced oxidative damage and inhibited the activities of antioxidant enzymes in rats kidney and liver. While, administration of camel's milk with Aluminum chloride minimized its hazards.
  Fahaid Al-Hashem
  Problem statement: Aluminum (Al) is an indifferent element from a toxicological point of view. In recent years, however, Al has been implicated in the pathogenesis of several clinical disorders. One of the most frequently described problem in aluminum toxicity is anemia. The present study was carried out to determine the effectiveness of Camel's milk in alleviating the toxicity of aluminum chloride (AlCl3) on certain hematological parameters, lipid peroxidation and oxidative stress enzyme in the RBC's of white albino rats. Approach: Ten rats per group were divided into three treatment groups: Group one were rats given normal saline and served as control group, group two were rats treated with 1 ml of AlCl3 (0.5 mg kg-1 body weight) and named AlCl3 treated rats, group 3 were rat treated with 1ml fresh camel's milk 10 min before the administration of AlCl3 (0.5 mg kg-1 body weight) and named Camel's milk and AlCl3 treated rats. Rats were orally administered their respective doses every day for 30 days. Evaluations were made for hematological parameters in the blood and for lipid peroxidation and oxidative stress enzymes activities in the RBC's. Results: Results obtained showed that oral AlCl3 treatment caused a significant decrease (p<0.05) in total erythrocytes count, blood Hemoglobin (Hb), hematocrite (PCV) and Serum iron levels, where as the values of Mean Corpuscular Volume (MCV), Mean Hemoglobin Concentration (MHC), Mean Corpuscular Hemoglobin Concentration (MCHC) and Total Ion Binding Capacity (TIBC) didn’t change. Also oral administration of AlCl3 induced free radicals and as a result caused an increase the concentration of Thiobarbituric Acid Reactive Substances (TBARS) and decreased activities of Superoxide Dismutase (SOD) and Catalsae (CAT) in the RBCs homolysate. The oral administration of Camel's milk before the administration of AlCl3, alleviated it's toxic effect. Camel's milk administration resulted in a significant increase (p<0.05) in the in total erythrocytes count, blood hemoglobin (Hb), hematocrite (PCV) and Serum iron with No change in the values of MCV, MHC, MCHC and TIBC when compared to AlCl3 treated rats. Camel's milk reduced free radicals production and oxidative stress status in the RBC's noticed by the significant decreased levels of TBARS and increased activities of SOD and CAT when compared to AlCl3 treated rats. Conclusion: our data proved that there is an alternation in the hematological parameters and antioxidant system in the red blood cells of rats administered aluminum chloride orally, whereas oral administration of Camel's milk prior the administration of Aluminum chloride protects the red blood cell form toxic effect of aluminum.
  Mohammad Khalil , Gamal Mohamed , Mohammad Dallak , Fahaid Al-Hashem , Hussein Sakr , Refaat A. Eid , Mohamed A. Adly , Mahmoud Al-Khateeb , Saleh Banihani , Zuhair Hassan and Nabil Bashir
  Problem statement: The goal of the current investigation was to clarify the effects of Citrullus colocynthis pulp extract on the structure of the liver of diabetic rats at both light and scanning electron microscopic levels. Approach: Forty-eight adult male albino rats were equally allocated into four groups: Group1: control, Group 2: Citrullus colocynthis-treated, Group 3: diabetic rats and Group4: diabetic rats treated with Citrullus colocynthis. All treatments were administered via an intragastric tube. Diabetes was induced in the rats of groups 3 and 4 by an intraperitoneal injection with alloxan. Results: The liver of Citrullus colocynthis-treated rats revealed minor histological changes versus the control animals. In group 3 animals, diabetes caused degenerative alterations in the form of disorganization of the hepatic cords, cytoplasmic vacuolization and pyknosis of the nuclei of hepatocytes and inflammatory cell infiltration. Scanning electron microscope examination of these livers revealed numerous lipid droplets within hepatocytes, damaged blood sinusoids and hemorrhage of erythrocytes between hepatocytes and inside Disse’s spaces. On the other hand, the normal histological and scanning ultrastructural features were nearly resumed in the liver of diabetic rats treated with Citrullus colocynthis pulp extract. Conclusion: The present study proved a lessening effect of Citrullus colocynthis pulp extract on the liver of diabetic rats. In light of these advantageous influences, it is advisable to widen the scale of its use in a trial to alleviate the diabetic hepatic adverse effects.
  Fahaid Al-Hashem , Mohammad Dallak , Nabil Bashir , Mohammad Abbas , Riyadh Elessa , Mohammad Khalil and Mahmoud Al-Khateeb
  Problem statement: Cadmium is one of the most dangerous occupational and environmental toxins. It is found in drinking water, atmospheric air and even in food. Cadmium is reported to be very toxic to biological systems. Until now in treating intoxication with this metal, chelating Compounds have been used, burdened with numerous undesirable symptoms. For this reason, many researches are carried out in many countries to find natural-made compounds that help in the protection against cadmium induced toxicity with fewer or no side effects. This study was conducted to demonstrate the effect of daily oral Camel's milk administration against Cadmium chloride induced toxicity in white albino rats. Approach: White albino rats of both sexes (230-250 g) were housed in standard metal cages (6 rats/cage). The experimental rats (6 in each group) distributed into two experimental groups with a shared control group received only normal saline orally (Group 1). In experimental first group a daily dose (10 mg kg1 body weight) of cadmium chloride was orally administrated to the rats for 21 days and named Cadmium chloride treated rats. In experimental second group, the same concentrations of cadmium chloride was dissolved in 2 mL of early morning fresh Camel's milk and the whole solution was administered into the experimental rats for 21 days and named Camel's milk cadmium chloride treated group. Water and food were provided ad libitum. Results: The data indicated that, in experimental Cadmium chloride treated rats, serum albumin, calcium and blood hemoglobin were decreased compared with control group received normal saline only. Moreover, Camel's milk administration with cadmium chloride showed a significant improvement of albumin, hemoglobin and calcium levels in the serum of the rats compared with cadmium chloride treated rats. Serum iron, sodium, chloride and urea levels were significantly increased in cadmium chloride treated rats compared with control group, while the addition of camel's milk to cadmium chloride decreased the high levels of these serum parameters in the treated rats. The enzyme activities of serum Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST) and serum Alkaline Phaospatase (ALP) were significantly increased by orally administration of cadmium chloride compared with control group, while adding Camel's milk to cadmium chloride decreased the high levels of these enzymes comparing with the cadmium chloride treated rats. Cadmium chloride administration resulted in a high concentration of lipid peroxidation markers; TBARS and Hydroperoxides in comparison to control group, adding camel's milk to the cadmium chloride restored the levels of these markers to their normal levels in comparing to Cadmium chloride treated rats. Also treatment with cadmium chloride alone caused a significant decrease in both the enzymatic and non-enzymatic markers of oxidative stress (superoxide dismutase and catalase) and reduced glutathione, respectively in the liver tissues of treated rats, while the administration of camel's milk with cadmium chloride increased and restored their levels to near normal in comparing with cadmium chloride treated rats. These results demonstrated that camel's milk had a protective effect against the toxicity induced by cadmium chloride. Conclusion: the above results indicated a protective effect of camel's milk oral administration against cadmium induced toxicity in white albino rats.
  Hussein F. Sakr , Fahaid Al-Hashem , Mahmoud Al-Khateeb , Abdullah S. Shatoor and Mamdoh Eskandar
  Problem statement: Cyclic guanosine 3’,5’-monophosphate cGMP is one the important second messengers that determines the cardiomyocyte activity and its role in healthy and diseased cardiac muscle is still controversial. We are reporting the effect of adding L-arginine, the NO donor that stimulates cGMP production and Sildenafil citrate (phosphodiestrase inhibitor) that inhibits cGMP hydrolyis on isolated rabbit’s heart to answer: Is it safe to prescribe phosphodiestrase inhibitors for men with low cardiac output? Approach: Isolated hearts from 6 rabbits were perfused using Langendorff’s apparatus in which the perfusion fluid was ringer-Locke solution, applied at constant flow rate and was continuously bubbled with a mixture of 95% oxygen and 5% carbon dioxide. Each heart served as its own control before infusion of L-arginine in concentration of 3 m mol L-1 and Sildenafil citrate 1.5 mg L-1 simultaneously. Their effects were recorded after 1, 3, 5 and 10 min. The effluent fluid was collected for cardiac enzymes assay after 5 and 10 min. Results: Data showed that the infusion of L-arginine and Sildenafil citrate produced negative inotrpic and chronotropic effects. Also, the cardiac enzymes were significantly elevated. Conclusion: The present study, which was carried out on the isolated rabbit’s heart, demonstrated that increased cGMP could produce a cardioprotective role by decreasing the cardiac work, although it might be hazardous to men with depressed cardiac function.
 
 
 
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