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Articles by F.W. Nmom
Total Records ( 2 ) for F.W. Nmom
  M.G. Ajuru , G. Ajuru , F.W. Nmom , C.W. Worlu and P.G. Igoma
  Background and Objective: Herbs were utilized by mankind since the ancient past, as alternative medicines for treatment of various diseases due to their presumed trustworthiness, efficacy, safety and low price. Catharanthus roseus (L.) G. Don is well known for its medicinal properties, like antibacterial, antifungal and antiviral. It is widely used in traditional medicine in India, Nigeria and West Indies to control diabetes mellitus. Toxicity studies serve as a preliminary study for identification of hazard and evaluation of the safety of any drug. This research was carried out to evaluate the acute toxic effects of ethanol leaves extract of C. roseus and to determine its median lethal dose (LD50). The objective was to investigate the toxicity of the leaves extract on the liver and biochemical parameters in rats. Materials and Methods: Single oral doses of the ethanol leaf extract of C. roseus was administered to albino rats at the concentrations 0, 1900, 3000 and 5000 mg kg–1. The animals were humanely sacrificed and blood and tissues obtained for biochemical and histological analysis on liver tissues. Results: The results revealed no significant changes in the control group but in the treatment group, there were changes such as dizziness, tremors and restlessness especially in treatment group D. Biochemical analysis showed normal alanine transaminase (ALT) levels in all treatment groups except in treatment group D where the level was significantly low (19 μ L–1). Aspartate transaminase (AST) was elevated in all treatment groups. Protein level was normal for all treatment groups except treatment group D where it was significantly low (26). Histological results showed normal liver tissues with hepatocytes, sinusoids and central veins. In treatment group B, there was tissue fragmentation with mild degeneration. In Group C, there was congestion in the central vein, vacuolation, fally, changes and necrosis of hepatocytes and connective tissues but in Group D, there were necrotic tissues in the liver. Conclusion: In this study, no mortality was recorded, therefore, the LD50 of the plant extract is slightly higher than 5000 mg kg–1 which can lead to mortality. It is recommended that studies on higher doses than the one in this study should be carried out to determine the actual LD50 of the drug.
  M.G. Ajuru and F.W. Nmom
  Background and Objective: Tracheophytes are group of plants characterized by the presence of vascular bundles; xylem and phloem. There are three groups of tracheophytes; Pteridophytes, Gymnosperms and Angiosperms. The main purpose of this study was to anatomically characterize representative members of the three groups of the vascular plants to show the evolutionary relationship among them. Materials and Methods: Fresh samples of the species were collected from different parts of Rivers state, fixed in Formalin, Acetic Acid (FAA) and alcohol, dehydrated in alcohol series, hand sectioned, stained with alcian blue and counter stained with safranin. Results: Results showed increasing number of vascular bundles from the lowest to highest group of plants. Amphicribral bundles were present in the Sword fern and collateral and open bundles in Sago palm, Caribbean Pine, African Jointfir and waterleaf, while there were scattered and closed bundles in day flower. The arrangement of vascular bundles were concentric in the ferns, omega shaped in Sago palm, found in a ring in the Pine, African Jointfir and waterleaf and scattered in the day flower, with vessel elements present in only Gnetum and the Angiosperms. Conclusion: The similarities among these group of plants point towards the same evolutionary origin while, the differences indicated the different level of evolutionary development among the plants.
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