|
|
| |
| Articles
by
F.O. Shode |
Total Records (
1 ) for
F.O. Shode |
|
 |
| |
|
| |
J.D. Habila
,
F.O. Shode
,
G.I. Ndukwe
,
J.O. Amupitan
and
A.J. Nok
|
| |
Background: Natural product compounds are the source of numerous chemotherapeutic agents. Investigations were carried out to evaluate the therapeutic properties of a C-3 modified oleanolic acid, 3β-acetoxyoleanolic acid (JH23), in the continue search for lead compounds. Results: The well-in-plate agar diffusion method used for the inhibition zone determination, showed that compound JH23 had a more enhanced activity as compared to JH16 (oleanolic acid) the parent nucleus, on most of the test organism; Candida guielemondi (JH23, 23±0.04; JH16, 22±0.03), Candida albicans (JH23, 29±0.05; JH16, 21±0.12), Candida krusei (JH23, 26±0.04; JH16, 23±0.001), Candida tropicalis (JH23, 30±0.02; JH16, 23±0.01), Trichophyton tonsurans (JH23, 29±0.03; JH16, 19±0.02) and Microsporum canis (30±0.01; JH16, 16±0.04). Conclusion: The results showed that functionality modification of organic compounds could lead to compounds with enhanced bioactivity. |
|
|
|
|
| |
|
