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Articles by F.O. Jimoh
Total Records ( 2 ) for F.O. Jimoh
  Srinivas Koduru , F.O. Jimoh , D.S. Grierson and A.J. Afolayan
  In this study two steroid glycosides were isolated from the berries of this plant, which were identified as tomatidine and solasodine by spectroscopic techniques. Antioxidant activities of these compounds were investigated using DPPH, ABTS and reducing power assays. The IC50 confirmed the antioxidant potentials of tomatidine and solasodine. DPPH free radical activity was examined at 30 and 60 min. The highest inhibition was observed when the two compounds were combined, followed by solasodine while tomatidine showed the least inhibition. On the other hand, the activity of ABTS was greater than the DPPH and the activity of the combined compounds was faintly less than solasodine. The activity observed in the reducing power assay was higher in the combined compounds and followed by solasodine and tomatidine. This study has revealed strong antioxidant activity and synergistic effect of the isolated compounds from S. aculeastrum berries.
  M.O. Sofidiya , F.O. Jimoh , A.A. Aliero , A.J. Afolayan , O.A. Odukoya and O.B. Familoni
  Lecaniodiscus cupanioides Planks. ExBth (Sapindaceae) is widely used in Nigerian folk medicine for the treatment of inflammatory conditions, hepatomegaly and bacterial infections. This study investigated the antioxidant and antibacterial activity of the methanolic extract of the leaves to justify its use in traditional medicine. Extract exhibited strong DPPH and ABTS radical scavenging activity greater than BHT and comparable to ascorbic acid. 0.1 mg mL-1 extract inhibited DPPH and ABTS radicals up to 99.4 and 98.5%, respectively. Multiple antioxidant activity of extract was evident with moderate reducing power. TAE (37.678±1.66 mg g1 dry extract) was higher than that reported in many other plant extracts. Flavonoid and proanthocyanidin contents were 4.142±0.06 and 2.548±0.32 mg g-1, respectively. Strong correlation recorded; ABTS/TAE (R2 = 0.89), DPPH/TAE (R2 = 0.90). Antimicrobial activity was highest on gram +ve organisms B. cereus, S. aureus, M. kristine and S. pyrogens (MIC value < 1.0 mg mL-1). Gram-ve S. pooni and P. aeruginosa (MIC value = 2.0 mg mL-1). Results attributed the antioxidant potential of L. cupanioides leaf extract to its strong proton donating ability and justified its use for the treatment of bacterial infections in ethnomedicine.
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