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Articles by F.O. Awobajo
Total Records ( 3 ) for F.O. Awobajo
  F.O. Awobajo , I.I. Olatunji-Bello and L.I. Ogbewey
  The reproductive impact of oral administration of aqueous leaf extract of Magnifera indica at a dose of 500 mg kg-1 was investigated. The first sets of non-gravid rats were used to study hormonal and estrous cycling pattern after extract for 4 weeks. Estrous cycle was monitored by vagina smear technique, weekly weight recorded and serum collected at the end of treatment period. The second set of gravid rats treated with the extract throughout the pregnancy period was used for the pregnancy study. Weekly weights were recorded while numbers of viable foetus and resorption sites were counted on gestational day 19 after laparotomy. In group that carried their pregnancy to term, number and weight of litter delivered were recorded. Both gravid and non-gravid rats treated with the extract experienced significant reduction in weight gained while there was also disruption of estrous cycling. Serum FSH level and litter birth weights were also significantly reduced. There was no effect on the number of viable foetus and duration of pregnancy. These results revealed that the aqueous extract of Magnifera indica disrupted oestrous cycling in female rat. The extract also interfered with weight gain with resultant reduction litter birth weight. It also produced a reduction in the FSH while increasing the estradiol level in non-pregnant rats. However, it has no significant effect on duration of pregnancy.
  Y. Raji , Olufadekemi T. Kunle-Alabi , S.B. Olaleye , M.A. Gbadegesin , F.O. Awobajo , O.A. Osonuga , A.O Odukanmi , S.A Salami and Adeyombo F. Bolarinwa
  Antimicrobial drugs have been reported to have adverse effects on male fertility. The present study reports the role of α- tocopherol on metronidazole and tetracycline induced reproductive alterations in albino rats. Male albino rats (5/group) were treated with 20 mg kg-1 bw day-1 metronidazole or 60 mg kg-1 day-1 tetracycline with or without 15 mg kg-1 bw α-tocopherol for 8 weeks. The reversibility of effects after 4 weeks recovery period was determined in separate groups of 5 rats. The control groups received distilled water (vehicle) and 15 mg kg-1 day-1 α- tocopherol for 8 weeks. Metronidazole and tetracycline significantly (p<0.05) reduced the weight of the epididymis, sperm count, motility and serum testosterone levels and increased the activity of endogenous superoxide dismutase (SOD) in the testis. Alpha-tocopherol significantly (p<0.05) decreased the weight of the testis, epididymis, sperm motility and serum testosterone levels. Co-administration of metronidazole or tetracycline with α-tocopherol caused significant restoration in sperm indices and SOD activity while it produced no effect on testosterone secretion. The results suggest that the effects of metronidazole and tetracycline on male reproductive functions, which are partially reversible, could be mediated via a reduction in serum testosterone level and probably also via the free radical generating mechanism.
  F.O. Awobajo , I.I. Olatunji-Bello , T.T. Obilade and T.O. Odugbemi
  The knowledge of the nutritional and medicinal benefits of some vegetables found around the south west-Nigeria was tested among cross section of market women in Lagos state Nigeria, using questionnaires and coloured pictures of seventeen of these vegetables. This study was carried out in Lagos state which houses a cross section of the nation ethnic groups and also serves as the commercial nerve centre of Nigeria. One thousand market women with varying level of education were selected and tested on proper identification and their knowledge on nutritional and medicinal benefits of seventeen vegetables found around them. Sociodemographic data such as age, educational status were also recorded. The results revealed high percentage school dropout among the market women. There is also a level of ignorance about the available vegetables around among the market women thou there seems to be a good appreciation of their medicinal values. Considering the capital base of these women especially the largest age bracket of 21-45 years, we suggested that financially empowering them will reduce the vicious circle of poverty associated with school dropout among girls in Nigeria. The populace need to be educated about the readily available vegetables around them to reducing the incidence of macronutrient deficiencies.
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