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Articles by F.O. Ajao
Total Records ( 3 ) for F.O. Ajao
  R.E. Akhigbe , M.O. Azeez , S.F. Ige , I.P. Oyeyipo , F.O. Ajao and A.O. Soladoye
  This study examined the effect of administration of combined Oral Contraceptive (OC) on blood viscosity and associated hemorheological parameters such as plasma viscosity, Pack Cell Volume (PCV), serum albumin, fibrinogen and total plasma proteins. Female wistar rats aged 7-10 weeks were selected and randomly distributed into two groups, the control group and the OC-treated group, with 20 rats in each group. The rats in both groups were fed with standard rat chow. After two weeks of acclimatization, rats in OC-treated group received OC therapy (containing 1.0 μg ethinyloestradiol and 10.0 μg of norgestrel), while rats in the control group remained on standard rat chow. After 7 weeks of treatment, hemorheological parameters were determined using standard hemorheological techniques described by Dacies and Lewis. Unpaired t-test was performed in all data with the significant level set at p<0.05. There was no significant change in level of fibrinogen, while there was significant increase in blood viscosity, plasma viscosity, PCV, serum albumin concentration and total plasma proteins in OC-treated rats. This finding suggests that increase blood viscosity and plasma viscosity seen in OC therapy is associated with an increase in PCV and serum albumin level.
  R.E. Akhigbe , S.F. Ige , A.O. Afolabi , P.I. Oyeyipo , F.O. Ajao and F.A. Ajayi
  This study was designed to investigate the effect of combined oral contraceptive (OC) on water consumption, urinary output and serum levels of sodium, potassium and calcium. Twenty female rats were used. Rats were distributed into two groups, control and OC-treated groups, with ten rats in each group. OC-treated group took combined OC, containing 1.0 μg ethinyloestradiol and 10.0 μg norgestrel intragastrically for nine weeks. Both groups fed on standard rat chow and were allowed free access to water throughout the nine weeks of experiment. Water consumption and urinary output was noted and recorded during the experiment period. After the experiment period, rats were sacrificed and serum levels of sodium and potassium were determined in both groups using the flame photometry method, while serum calcium level was determined in both groups using cresolphthalein complexone. There was significant decrease in water consumption and urinary output. No significant differences were found in the mean serum levels of sodium, potassium and calcium.
  S.F. Ige , R.E. Akhigbe , A.A. Adewale , J.A. Badmus , S.B. Olaleye , F.O. Ajao , W.A. Saka and O.Q. Owolabi
  This study aims at investigating the effect of pre-treatment, co-treatment and post-treatment with Allium cepa extract, AcE, on cadmium-induced renal toxicity and confirming possible mechanisms by which Allium cepa extract reduce/restore cadmium induces nephrotoxicity. Thirty male Sprague Dawley rats were used. They were divided into 5 groups (n = 6). Group 1 was used as control. Group 2 was intraperitoneally administered 1.5 mL kg-1 BW of 0.3 mg L-1 of cadmium sulphate for 3 days. Group 3 was pretreated with 1.0 mL kg-1 BW of AcE for 8 weeks followed by intraperitoneal administration of 1.5 mL kg-1 b.wt. of 0.3 mg L-1 of cadmium sulphate. Group 4 was co-treated with 1.5 mL kg-1 BW of 0.3 mg L-1 of cadmium sulphate for 3 days and 1.0 mL kg-1 BW of AcE for 8 weeks simultaneously. Group 5 was post-treated with 1.0 mL kg-1 BW of cadmium sulphate for 8 weeks following a 3 day course of 1.5 mL kg-1 BW of 0.3 mg L-1 of cadmium sulphate intraperitoneal administration. All groups were allowed free access to standard rat chow and water throughout the period of experiment. After the experiment period, rats were sacrificed by cervical dislocation and blood sample were obtained via cardiac puncture. The kidneys were also excised. Changes in body and kidney weights were determined. Renal weight index, 24 h urine volume, renal clearance and lipid peroxidation status were also determined. There was no significant change in body and kidney weight and renal weight index in all groups. Renal clearance and 24 h urine volume were significantly reduced in group 2 rats when compared to all groups. Renal clearance was also reduced in group 3 and 5, though this decrease was only significant when compared with the control group. Plasma and tissue SOD activities were significantly increased in group 2. Plasma and tissue MDA levels were significantly increased in group 2, 3 and 5. This study shows that cadmium induces nephrotoxicity by impairing renal functions and stimulating lipid peroxidation. Pre-treatment and post-treatment of AcE in cadmium-treated rats produced mild protective potentials. However, co-treatment with AcE during cadmium administration showed significant antioxidative potentials in preventing cadmium-induced nephrotoxicity.
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